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omp19 from Brucella melitensis bv. 1 str. 16M

Victor ID 1205
Gene Name omp19 from Brucella melitensis bv. 1 str. 16M
Sequence Strain (Species/Organism) Brucella melitensis bv. 1 str. 16M
NCBI Gene ID 1195847
NCBI Protein GI 17986419
Locus Tag BMEI0135
Protein Accession NP_539053.1
Other Database IDs UniProtKB-ID: D0B3H9_BRUME
UniRef100: UniRef100_Q2YLR6
UniRef90: UniRef90_Q2YLR6
UniRef50: UniRef50_Q2YLR6
UniParc: UPI0000057B74
EMBL: GG703778
EMBL-CDS: EEW87953.1
RefSeq_NT: NC_003317.1
OMA: LAKVSAW
Taxonomy ID 224914
Chromosome No I
Gene Starting Position 130095
Gene Ending Position 130628
Gene Strand (Orientation) +
Protein Name OUTER MEMBRANE LIPOPROTEIN
DNA Sequence 
>gi|17986284:130095-130628 Brucella melitensis bv. 1 str. 16M chromosome chromosome I, complete sequence
GATGGGAATTTCAAAAGCAAGTCTGCTCAGCCTCGCGGCGGCTGGCATTGTCCTGGCCGGGTGCCAGAGC
TCCCGGCTTGGTAATCTCGATAATGTTTCGCCTCCGCCGCCGCCTGCACCGGTCAATGCTGTTCCGGCAG
GCACGGTGCAGAAAGGCAATCTTGATTCTCCCACACAATTCCCCAATGCGCCCTCCACGGATATGAGCGC
GCAATCCGGCACACAGGTCGCAAGCCTGCCGCCTGCATCCGCACCGGACCTGACGCCCGGCGCCGTGGCT
GGCGTCTGGAACGCCTCGCTTGGTGGTCAGAGCTGCAAGATCGCGACGCCGCAGACCAAATATGGCCAGG
GCTATCGCGCAGGCCCGCTGCGCTGCCCCGGTGAACTGGCTAATCTTGCCTCCTGGGCCGTCAATGGCAA
GCAACTCGTCCTTTACGATGCGAACGGCGGTACGGTTGCCTCGCTCTATTCTTCAGGACAGGGCCGCTTC
GATGGCCAGACCACCGGCGGGCAGGCCGTGACGCTGTCGCGCTG
Protein Sequence 
>gi|17986419|ref|NP_539053.1| outer membrane lipoprotein [Brucella melitensis bv. 1 str. 16M] MGISKASLLSLAAAGIVLAGCQSSRLGNLDNVSPPPPPAPVNAVPAGTVQKGNLDSPTQFPNAPSTDMSAQSGTQVASLPPASAPDLTPGAVAGVWNASLGGQSCKIATPQTKYGQGYRAGPLRCPGELANLASWAVNGKQLVLYDANGGTVASLYSSGQGRFDGQTTGGQAVTLSR
Molecule Role Virulence factor
Molecule Role Annotation SUBCELLULAR LOCATION: Outer membrane; lipid-anchor(UniProt: P0A3P2).

MISCELLANEOUS: Elicits an immune response in humans, mice, sheep and goats infected with B.melitensis or B.abortus, but not in B.abortus-infected cattle(UniProt: P0A3P2).

SIMILARITY: Belongs to the rhizobiaceae omp19 lipoprotein family(UniProt: P0A3P2).

MUTATION: Omp19 is an immunoreactive outer membrane lipoprotein. Significantly fewer brucellae were recovered from the spleens of mice infected with the omp19 mutant than from those of mice infected with the parent strain at 4 and 8 weeks postinfection. The omp19 mutant exhibited an increase in sensitivity to the polycation polymyxin B and to sodium deoxycholate. These results indicate that inactivation of the omp19 gene alters the outer membrane properties of B abortus (Tibor et al., 2002).
References
Tibor et al., 2002: Tibor A, Wansard V, Bielartz V, Delrue RM, Danese I, Michel P, Walravens K, Godfroid J, Letesson JJ. Effect of omp10 or omp19 deletion on Brucella abortus outer membrane properties and virulence in mice. Infection and immunity. 2002; 70(10); 5540-5546. [PubMed: 12228280].