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mutM from Brucella suis 1330

Victor ID 1116
Gene Name mutM from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167886
NCBI Protein GI 23503030
Locus Tag BR2183
Protein Accession NP_699157.1
Other Database IDs UniProtKB-ID: FPG_BRUSU
UniRef100: UniRef100_A9MAB2
UniRef90: UniRef90_B2S9T2
UniRef50: UniRef50_Q13EN7
UniParc: UPI00000DD7EC
EMBL: AE014291
EMBL-CDS: AAN31072.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR2183
NMPDR: fig|204722.1.peg.2114
TIGR: BR2183
HOGENOM: HBG690070
OMA: RSTFYCA
ProtClustDB: PRK01103
BioCyc: BSUI204722:BR_2183-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 2105204
Gene Ending Position 2106085
Gene Strand (Orientation) +
Protein Name formamidopyrimidine-DNA glycosylase
DNA Sequence 
>gi|56968325:2105204-2106085 Brucella suis 1330 chromosome I, complete sequence
TATGCCGGAACTGCCAGAGGTCGAAACGGTTCGCCGTGGTCTGCAACCCTTCATGGAAGGGGCAACCGTT
GTGCGGGTGGAGCAGAATCGGCCCGACCTGCGCTTTGCCTTTCCTGAAAATTTTGCCGAACGCCTTTCCG
GCAGGCGCATCGAGGCGCTTGGCCGCCGTGCGAAATATCTGACCGTCCATCTCGATGACGGGCTTTCGAT
CATCAGCCATCTCGGCATGTCCGGCTCGTTTCGCATTGAGGCGGAGGATGCGCAAGGTTTGCCGGGCGGG
TTTCATCACGAGCGCTCCAAGAACAGCCTGCATGACCATGTGGTCTTTCACCTCATGCGCCCGGACGGTG
CGTCTGCACGCATTATTTATAATGATCCGCGCCGCTTCGGTTTCATGCTCTTTGCCGAAAAGGGCGCGCT
GGAGGAACATCCGCTCCTGAAAGACCTTGGTGTGGAGCCGACCGGCAATCTCCTGTCGGGCGAGGTTCTG
GCCGCGCTTTTCAAGGGACGCCGCAAGCCCCTGAAGGCCGCCTTGCTCGACCAGAGGCTTATCGCGGGGC
TTGGCAATATCTATGTCTGCGAGGCGCTCTGGCGCGCAGGGCTTTCGCCGATGCGCGCGGCAGGCTCGGT
TGCAGGCGAAATGGACGTGATGGAGCGGCTTGCCGGGGCCATTCGCTCCGTCATTGCGCAGGCGATTGCA
GCCGGAGGCTCCAGCCTTAAGGATTACATTCAGGCCGACGGTGCGCTCGGCTATTTCCAGCACTCTTTTT
CCGTCTATGGCCGCGAGGGTAAGCCATGCAGAAACCCCGCCTGCGGCGGCACTGTCGAGCGCGTGGTGCA
ATCTGGTCGTTCGACTTTTTTCTGTGCCTCCTGCCAGACATG
Protein Sequence 
>gi|23503030|ref|NP_699157.1| formamidopyrimidine-DNA glycosylase [Brucella suis 1330] MPELPEVETVRRGLQPFMEGATVVRVEQNRPDLRFAFPENFAERLSGRRIEALGRRAKYLTVHLDDGLSIISHLGMSGSFRIEAEDAQGLPGGFHHERSKNSLHDHVVFHLMRPDGASARIIYNDPRRFGFMLFAEKGALEEHPLLKDLGVEPTGNLLSGEVLAALFKGRRKPLKAALLDQRLIAGLGNIYVCEALWRAGLSPMRAAGSVAGEMDVMERLAGAIRSVIAQAIAAGGSSLKDYIQADGALGYFQHSFSVYGREGKPCRNPACGGTVERVVQSGRSTFFCASCQT
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)(UniProt: Q8FXR6).

CATALYTIC ACTIVITY: Hydrolysis of DNA containing ring-opened N(7)-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine(UniProt: Q8FXR6).

CATALYTIC ACTIVITY: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate(UniProt: Q8FXR6).

COFACTOR: Binds 1 zinc ion per subunit (By similarity)(UniProt: Q8FXR6).

SUBUNIT: Monomer (By similarity)(UniProt: Q8FXR6).

SIMILARITY: Belongs to the FPG family(UniProt: Q8FXR6).

SIMILARITY: Contains 1 FPG-type zinc finger(UniProt: Q8FXR6).

MUTATION: Attenuated in Differential fluorescence induction (Delrue et al., 2004).
COG COG0266L, under L: Replication, recombination and repair
References
Delrue et al., 2004: Delrue RM, Lestrate P, Tibor A, Letesson JJ, De Bolle X. Brucella pathogenesis, genes identified from random large-scale screens. FEMS microbiology letters. 2004; 231(1); 1-12. [PubMed: 14979322].