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hisC from Brucella suis 1330

Victor ID 1110
Gene Name hisC from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167688
NCBI Protein GI 23502835
Locus Tag BR1987
Protein Accession NP_698962.1
Other Database IDs UniProtKB-ID: HIS8_BRUSU
UniRef100: UniRef100_Q2YR81
UniRef90: UniRef90_Q2YR81
UniRef50: UniRef50_A7ICA9
UniParc: UPI00000DD758
EMBL: AE014291
EMBL-CDS: AAN30877.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR1987
TIGR: BR1987
HOGENOM: HBG646350
OMA: NPANILC
ProtClustDB: PRK02731
BioCyc: BSUI204722:BR_1987-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1915245
Gene Ending Position 1916342
Gene Strand (Orientation) +
Protein Name histidinol-phosphate aminotransferase
DNA Sequence 
>gi|56968325:1915245-1916342 Brucella suis 1330 chromosome I, complete sequence
CATGCAGAAACCTACCCGTCCCCAGCCCAAGGCAGGCGTGCTTGACATTGCAGCCTATGTACCCGGCAAG
GAACATGTGGAAGGCGTTGCCAAGGTCTATAAGCTCTCCTCCAACGAAACCCCGCTTGGACCAAGCCCCC
ATGCCAGGGAAGCCTACCGGCATGCGGGCGAAAAGCTTGAGCTTTACCCGGACGGGCAGGCACTGGCGCT
GCGGCAGGCGATTGCGGAAACGCAGGGGCTCAACATTTCCAACATTCTGTGCGGCAACGGATCCGACGAA
TTGCTGGGCCTTCTCTGCCAGACCTATCTTGCCCCCGGTGACGAAACCATCATCACCGAGCACGGCTTTG
CCGTTTACAAGATCCAGACGCTCGCAGCCGGCGCCACCCCCGTCACGGTGAAGGAAAAGAACGAACGCAT
CGATGTGGACGCCATCCTCGCAGGTGTGACGGCGCGCACAAAAATCGTCTTCATCGCCAATCCGGCCAAC
CCGACCGGCACTTATCTGCCTTTTGAGGAAGTGCGCCGCCTCCATGCGGGCCTGCCGCAGCATGTTCTGC
TGGTGCTCGACGCCGCCTATGCCGAATATGTGCGCCGCAACGATTATGAAGCCGGGCTGGAACTCGTTTC
ATCCAATGAAAACGTGGTGATGACGCGCACTTTCTCGAAGATTCACGGCCTGCCCGGCCTGCGCATCGGC
TGGATTTATGCGCCGCTCCACATCATCGACGCCATGAACCGCATCCGCGGCCCCTTCAACATGAATTCCG
CCGCGATTGCTGCGGGCGCCGCCGCGATCCGCGATCGTGCACATGTCGAAAAATCGGTCGCCTATAACGA
GAAATGGCTTGCCTGGCTCACGGAAGAATTCACCAGGCTCGGTCTGCGGGTTACACCTTCCGTGACGAAC
TTCCTGCTCATTCATTTCCCCGATGATGCCGCCCATTCGGCAGACAAGGCCGATGAATGGCTATCGAGGC
GCGGCTATATTCTCCGCCGTGTCGGGGGCTATGGTTTCCCCAATGCACTGCGCATGACGGTGGGACCAGA
AGAAGCCAATCGCGGTGTGGTAGCCGCCCTCACAGAATTTCTGAAGTA
Protein Sequence 
>gi|23502835|ref|NP_698962.1| histidinol-phosphate aminotransferase [Brucella suis 1330] MQKPTRPQPKAGVLDIAAYVPGKEHVEGVAKVYKLSSNETPLGPSPHAREAYRHAGEKLELYPDGQALALRQAIAETQGLNISNILCGNGSDELLGLLCQTYLAPGDETIITEHGFAVYKIQTLAAGATPVTVKEKNERIDVDAILAGVTARTKIVFIANPANPTGTYLPFEEVRRLHAGLPQHVLLVLDAAYAEYVRRNDYEAGLELVSSNENVVMTRTFSKIHGLPGLRIGWIYAPLHIIDAMNRIRGPFNMNSAAIAAGAAAIRDRAHVEKSVAYNEKWLAWLTEEFTRLGLRVTPSVTNFLLIHFPDDAAHSADKADEWLSRRGYILRRVGGYGFPNALRMTVGPEEANRGVVAALTEFLK
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate(UniProt: Q8FY98).

COFACTOR: Pyridoxal phosphate (By similarity)(UniProt: Q8FY98).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7(UniProt: Q8FY98).

SUBUNIT: Homodimer (By similarity)(UniProt: Q8FY98).

SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily(UniProt: Q8FY98).

MUTATION: hisC encodes for histidinol phosphate transaminase. Brucella hisC mutant showed very little reduction in number by 2 weeks post-inoculation, but was reduced by 8 weeks.
COG COG0079E, under E: Amino acid transport and metabolism
References