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purH from Brucella suis 1330

Victor ID 1103
Gene Name purH from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167509
NCBI Protein GI 23502669
Locus Tag BR1816
Protein Accession NP_698796.1
Other Database IDs UniProtKB-ID: PUR9_BRUSU
UniRef100: UniRef100_A9M854
UniRef90: UniRef90_B2S7P0
UniRef50: UniRef50_B3DRY6
UniParc: UPI0000057BD6
EMBL: AE014291
EMBL-CDS: AAN30711.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR1816
TIGR: BR1816
HOGENOM: HBG498048
OMA: ASDGFFP
ProtClustDB: PRK00881
BioCyc: BSUI204722:BR_1816-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1747046
Gene Ending Position 1748662
Gene Strand (Orientation) +
Protein Name bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
DNA Sequence 
>gi|56968325:1747046-1748662 Brucella suis 1330 chromosome I, complete sequence
TATGGCTGTCAGCTCCAAGCATATTCCCGCTCCCGATCTTCATCGGGTGCGCCGCGCCCTCCTTTCCGTT
TCCGACAAAACCGGCCTGATCGATTTCGCCAAGGCGCTTCATGCCAATGGCGTCGAAATCCTCTCGACCG
GCGGCACAGCAAAATCGATTGCCGCCGCAGGCATTCCGGTGAAGGACGTATCCGAAATCACCGGCTTTCC
GGAAATCATGGATGGGCGCGTCAAGACGCTGCATCCGGCAGTCCATGGCGGCCTGCTCGCCGTGCGCAAC
GACCCGGAACATGTCGCGGCCATGGAAGAACACGGCATTGGCGGCATCGATCTTGCCGTCATCAATCTTT
ATCCGTTCGAGGAAGTCCGCTTCAAGGGCGGCGACTACGACACGACCGTCGAGAATATCGACATTGGCGG
CCCGGCGATGATCCGCGCTTCGGCCAAGAACCACGCCTATGTCGCAACCGTCGTTGACCCTGCCGATTAT
GCAGACGTCGTGGCTGAACTGGAAAAGCATTCCGGCTCCCTGCCGCTTGCCTTCCGCAAAAAGCTTGCCG
CCAAGGCCTTTTCGCGCACGGCAGCTTATGACGCGGCCATTTCCAACTGGTTTGCCGAAGCAATCGACGA
AGAAACGCCGACCTATCGCGCGGTTGCCGGCAAGCTGCATTCCGTCATGCGCTACGGTGAAAACCCGCAC
CAGACGGCTGGCTTTTATCTCACCGGCGAAAAGCGCCCCGGCGTTGCCACTGCGACCCAGCTTCAGGGCA
AGCAGCTTTCCTATAACAACATCAACGATACCGATGCGGCTTTTGAGCTGGTGGCCGAATTCGATCCCGC
CCGCACCGCAGCCGTTGCCATCATCAAGCACGCCAATCCATGCGGCGTGGCGGAAGCGTCCACCATTAAG
GAAGCCTACCTCAAGGCACTCGCCTGCGATCCGGTTTCGGCCTTTGGCGGCATTGTCGCGCTCAACAGGA
CGCTCGATGAGGAAGCCGCTGAAGAGATCGTGAAAACCTTCACAGAAGTCATCATCGCGCCCGATGCCAC
CGAAGGCGCACAGGCCATCGTCGCGGCCAAGAAGAACCTGCGCCTGCTTGTCACCGGCGGCCTGCCGGAC
CCGCGCGCCAAGGGCATTGCCGCCAAGACGGTTGCCGGTGGCCTGCTGGTCCAGTCGCGCGACAATGGTG
TGGTGGACGATCTCGATCTCAAGGTCGTCACCAAGCGCGCACCGACCGAAGCCGAGCTTAACGATCTGAA
ATTCGCCTTCCGCGTCGGCAAGCATGTGAAGTCGAACGCCATCGTCTATGTGAAGGACGGCGCAACGGTC
GGCATTGGCGCAGGCCAGATGAGCCGCGTGGATTCAGCCCGCATTGCCGCCCGCAAGGCAGAAGATGCGG
CCGAAGCCGCCGGCCTTGCAGCGCCGCTCACCAAGGGCTGCGTGGTCGCGTCCGATGCATTCTTCCCCTT
TGCAGACGGTCTGCTTTCCGCTGTCGAGGCCGGTGCAACCGCCGTCATCCAGCCGGGCGGCTCCATGCGT
GACGACGAAGTGATCGCCGCTGCCGATGAACATGGCATCGCCATGGTCATGACGGGGATGCGCCACTTCC
GCCACTG
Protein Sequence 
>gi|23502669|ref|NP_698796.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Brucella suis 1330] MAVSSKHIPAPDLHRVRRALLSVSDKTGLIDFAKALHANGVEILSTGGTAKSIAAAGIPVKDVSEITGFPEIMDGRVKTLHPAVHGGLLAVRNDPEHVAAMEEHGIGGIDLAVINLYPFEEVRFKGGDYDTTVENIDIGGPAMIRASAKNHAYVATVVDPADYADVVAELEKHSGSLPLAFRKKLAAKAFSRTAAYDAAISNWFAEAIDEETPTYRAVAGKLHSVMRYGENPHQTAGFYLTGEKRPGVATATQLQGKQLSYNNINDTDAAFELVAEFDPARTAAVAIIKHANPCGVAEASTIKEAYLKALACDPVSAFGGIVALNRTLDEEAAEEIVKTFTEVIIAPDATEGAQAIVAAKKNLRLLVTGGLPDPRAKGIAAKTVAGGLLVQSRDNGVVDDLDLKVVTKRAPTEAELNDLKFAFRVGKHVKSNAIVYVKDGATVGIGAGQMSRVDSARIAARKAEDAAEAAGLAAPLTKGCVVASDAFFPFADGLLSAVEAGATAVIQPGGSMRDDEVIAAADEHGIAMVMTGMRHFRH
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(UniProt: P67540).

CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(UniProt: P67540).

PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): single step(UniProt: P67540).

PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: single step [final step](UniProt: P67540).

PATHWAY: Context: Purine biosynthesis(UniProt: P67540).

DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal region (By similarity)(UniProt: P67540).

SIMILARITY: Belongs to the purH family(UniProt: P67540).

MUTATION: B. abortus mutant with mini-Tn5-disrupted purH displays nutritional defects in vitro (Alcantara et al., 2004).
COG COG0138F, under F: Nucleotide transport and metabolism
References
Alcantara et al., 2004: Alcantara RB, Read RD, Valderas MW, Brown TD, Roop RM 2nd. Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model. Infection and immunity. 2004; 72(8); 4911-4917. [PubMed: 15271960].