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pyc from Brucella suis 1330

Victor ID 1101
Gene Name pyc from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167474
NCBI Protein GI 23502636
Locus Tag BR1781
Protein Accession NP_698763.1
Other Database IDs UniProtKB-ID: Q8FYT0_BRUSU
UniRef100: UniRef100_A5VSC6
UniRef90: UniRef90_A6WXY5
UniRef50: UniRef50_A6UE85
UniParc: UPI00000DD6BE
EMBL: AE014291
EMBL-CDS: AAN30678.1
RefSeq_NT: NC_004310.3
HSSP: P24182
GenomeReviews: AE014291_GR
KEGG: bms:BR1781
NMPDR: fig|204722.1.peg.1720
TIGR: BR1781
HOGENOM: HBG717218
OMA: DIVQSQI
ProtClustDB: PRK12999
BioCyc: BSUI204722:BR_1781-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1709999
Gene Ending Position 1713475
Gene Strand (Orientation) -
Protein Name pyruvate carboxylase
DNA Sequence 
>gi|56968325:1709999-1713475 Brucella suis 1330 chromosome I, complete sequence
CTTACTCGGCGTAAACGATGAGCAAATCCTTCGCGTCGATCTGCTCGCCGGGGCGGACCAGCACTTCCGC
GATAGTGCCATCGCGTTCGGCATGGATGGCGGTTTCCATCTTCATCGCCTCGATGGATAGAAGCACGTCG
CCCTGCGTAACCTTCTGGCCTGCCACAACCGCAACGGTGGAGATAACGCCCGGCATCGGCGCACCGACCT
GTTTGTCATTGCCCGCCTCCACCTTGCGGCGGACACCACCGGAAGCACCCTTGGCACGGTTTGGCACCTT
GATGCGGCGCGGCTGGCCGTTCAGCTCGAAGAACACCGTCACCATGCCCTTCTCGTCGGTCTCGCTCATA
GCCTGATTGACGATCACCAGCGTCTTGCCACGCTCCAGATCGACAAAAACTTCTTCTTCCGGCTTGAGGC
CGTAGAAATAAACCGGCGTCGGCAGCACGCTCGTCGGACCATAGGTTTCATGCGCCGTAGCATAATCGGT
GAAGACCTTCGGATACATCAGCGCCGAAGCAAATTCCTGATCGGAAAGCTTGCGGCCGACACTGTCCTCA
AAGCTCTTGCGTTCCGCATCGAGATCGGCGGCAGGCAGAAGCGAGCCGGGGCGCACGGTGAAAGGCTTTT
CACCTTTCAGAACCTTTTTCTGCAAGGCTTCCGGCCAGCCGGATGGCGGCTGGCCGAGATCGCCACGCAT
CATGGAAACCACCGAATCCGGGAAGGCAATATCCTTGGCAGGGTTCTCGACATCGGCAACGGTGAGGTCT
TGGGCAACCATCATCAGCGCCATGTCGCCCACCACCTTGGAGGATGGCGTGACCTTGACGATATCGCCGA
ACATGCGGTTCACATCGGCATAGGCCTGCGCCACTTCATGCCAGCGCGTTTCAAGCCCCAGCGAGCGCGC
CTGTTCCTTCAGATTGGTGAACTGGCCACCCGGCATTTCGTGAAGATAGACTTCCGAAGCCGGTCCCTTG
AGGTCGCTTTCAAAAGCTGCATATTGATGGCGCACCGCTTCCCAATAAAAGGAAATACGGCGGATCGAAT
CCGGGTCGAGCCCCGAATCACGCTCGGAACCATGCAGCGCTTCAACGATGGAACCGAGGCAGGGCTGCGA
TGTATTGCCCGAAAGTGCGTCCATCGCTGCATCCACGACATCCACGCCCGCATCGATTGCAGCAAGCACG
GTCGCCGCCGAAATGCCCGACGTATCATGTGTGTGGAAATGGATCGGCAGATCGGTTTCCTCGCGCAGCG
CCTTGAACAGCACGCGCGCGGCGGCAGGCTTCAGCAAGCCCGCCATATCCTTGACCGCAATAATATGCGC
GCCAGCCTTTTCCACTTCCTTCGCCAGATTGACGTAATAATTAAGGTCGTATTTGGCGCGATCCGGGTTC
AAAATATCGCCCGTATAGCAGATCGCCGCTTCACAGAGCTTGTTTTCCTCCAGCACCGCATCCATCGACA
CGCGCATGTTCTCAACCCAGTTGAGGCTGTCGAAAACGCGGAACAGGTCAATGCCTGCGCGCGCTGCCTC
GCGCACGAAATATTTCACCACATTGTCCGGATAGGATTTGTAGCCAACCCCGTTCGCACCGCGCAGAAGC
ATCTGCAACAGGAGGTTGGGCGCGCCTTCGCGCACCAGTGCCAGACGCTCCCACGGGTCTTCGGTCAGGA
AGCGCATGGAGACGTCGAAAGTAGCCCCGCCCCAGCATTCCAGCGAGAACAGGTTTGGCAGCGCCTGCGC
GTAAGCATTGGCGATCCGCGCAATATCATAGGTGCGCACGCGCGTGGCAAGCAATGACTGGTGGCCATCG
CGCATGGTGGTATCAGTAATCAGCGCGCGCTTTTCATTGCGCATCCATTCGGCAAACTTCTTCGGCCCAA
GCTGGTCCAGAAGCTGTTTGGTGCCGTCAGCGACCAGCTTGTCGCCAAACCACGGCACGCGCGGCTTGGC
AGCATCCCTGGCGGGTTTCGCGCGGCCCTTGGTTTCGGGATGGCCGTTGACGGTCACATCGGCAATATAG
GTCAAAAGCTTGGTGGCGCGATCCTGCCGCTTCATCTGCTCGAACAATTCCGGCGTCGTATCGATGAAAC
GGGTCGTATAATCGTTCGACTGGAATTTCGGATGATTGATGATCGCTTCGAGGAAGGTGAGGTTCGTTGC
CACGCCGCGAATGCGGAACTCGCGCAAGGCGCGGTCCATGCGGTGAATGGCTTCAAGCGGCGTCGCGCCG
GATGCCGTCACCTTTACCAGAAGCGGGTCGTAATAACGGGTGATGAATGCGCCCGAATAGGCCGTGCCGC
CATCGAGACGGATGCCGAAGCCCGCCGCCGAACGATAGGCCTGAATGCGCCCGTAATCGGGGATGAAATT
CTGTTCCGGGTCTTCCGTTGTGATGCGGCATTGCAGCGCGTGGCCATTGAGGCGGATATCCTCCTGGCGC
GGCACGCCCGATTCCGGCGTGCCGATGGCAAAGCCTTCCAGAATATGGATCTGCGCCTTGACGATATCGA
TGCCGGTCACTTCTTCCGTGACCGTATGCTCCACCTGAATGCGTGGATTGACCTCGATGAAATAGAACTT
GCCGGTATCGGCATCCATGAGGAACTCAACCGTGCCAGCACCGATATAATCGGTGGCATGCGCGATCTTC
AGGCCATAATCGGCCAGCTCGCGGCGCTGCGCATCGTTGAGATAGGGTGCAGGCGCGCGCTCCACGACCT
TCTGGTTACGGCGCTGGATGGAGCAGTCACGCTCAAAAAGATGGACCGCATTGCCGTACGTATCGCCCAA
TATCTGCACTTCGACATGGCGGGCACGCTCCACCAGCTTTTCGAGATAAACTTCATCCTTGCCAAAGGCC
GCCTTGGCCTCGCGCTTGGCTTCCATCACCTCGCGGGCAAGATCGGCTTCAGCCCGGATGGCGCGCATAC
CGCGGCCGCCGCCGCCCCAGCTTGCTTTCAGCATCAGCGGATAGCCGATCTGGGCGGCAAGCTTCTTCAC
CTCATCCATATCATCCGGCAGCGGATCGGTGGCAGGCACCACCGGCACGCCAATCTCGATAGCGAGATTG
CGCGCGGCGACCTTGTTGCCGAGGCGGCGCATGGTTTCCGGCTTCGGCCCGATGAAGACGATACCGTTTT
CCGCGCAGGCTTCGGCAAATTCCGGGCTTTCCGACAGGAGACCGTAACCTGGATGGATCGCATCGGCGCC
CGAAAGCTTGGCAACGCGGATGATTTCGTCAATGGAAAGATAGCTTTCAATGGGGCCAAGATCGCGATCC
AGATGCGGTCCGCGACCGACCTGATAGCTTTCATCCGCCTTGAAGCGATGCAGGGAAAGCTTGTCTTCCT
CAGCCCATATGGCCACCGTTTTGAGCCCCAGCTCATTGGCGGCGCGGAATACGCGAATTGCGATTTCAGA
TCGGTTGGCGACCAGAATTTTCGAGATAGGCTTTGGAGCGAAAGACA
Protein Sequence 
>gi|23502636|ref|NP_698763.1| pyruvate carboxylase [Brucella suis 1330] MSFAPKPISKILVANRSEIAIRVFRAANELGLKTVAIWAEEDKLSLHRFKADESYQVGRGPHLDRDLGPIESYLSIDEIIRVAKLSGADAIHPGYGLLSESPEFAEACAENGIVFIGPKPETMRRLGNKVAARNLAIEIGVPVVPATDPLPDDMDEVKKLAAQIGYPLMLKASWGGGGRGMRAIRAEADLAREVMEAKREAKAAFGKDEVYLEKLVERARHVEVQILGDTYGNAVHLFERDCSIQRRNQKVVERAPAPYLNDAQRRELADYGLKIAHATDYIGAGTVEFLMDADTGKFYFIEVNPRIQVEHTVTEEVTGIDIVKAQIHILEGFAIGTPESGVPRQEDIRLNGHALQCRITTEDPEQNFIPDYGRIQAYRSAAGFGIRLDGGTAYSGAFITRYYDPLLVKVTASGATPLEAIHRMDRALREFRIRGVATNLTFLEAIINHPKFQSNDYTTRFIDTTPELFEQMKRQDRATKLLTYIADVTVNGHPETKGRAKPARDAAKPRVPWFGDKLVADGTKQLLDQLGPKKFAEWMRNEKRALITDTTMRDGHQSLLATRVRTYDIARIANAYAQALPNLFSLECWGGATFDVSMRFLTEDPWERLALVREGAPNLLLQMLLRGANGVGYKSYPDNVVKYFVREAARAGIDLFRVFDSLNWVENMRVSMDAVLEENKLCEAAICYTGDILNPDRAKYDLNYYVNLAKEVEKAGAHIIAVKDMAGLLKPAAARVLFKALREETDLPIHFHTHDTSGISAATVLAAIDAGVDVVDAAMDALSGNTSQPCLGSIVEALHGSERDSGLDPDSIRRISFYWEAVRHQYAAFESDLKGPASEVYLHEMPGGQFTNLKEQARSLGLETRWHEVAQAYADVNRMFGDIVKVTPSSKVVGDMALMMVAQDLTVADVENPAKDIAFPDSVVSMMRGDLGQPPSGWPEALQKKVLKGEKPFTVRPGSLLPAADLDAERKSFEDSVGRKLSDQEFASALMYPKVFTDYATAHETYGPTSVLPTPVYFYGLKPEEEVFVDLERGKTLVIVNQAMSETDEKGMVTVFFELNGQPRRIKVPNRAKGASGGVRRKVEAGNDKQVGAPMPGVISTVAVVAGQKVTQGDVLLSIEAMKMETAIHAERDGTIAEVLVRPGEQIDAKDLLIVYAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pyc is one B. suis gene identified by signature-tagged mutagenesis. It is essential for survival and mulitplication in macrophages (Foulongne et al., 2000).
COG COG1038C, under C: Energy production and conversion
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].