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dut from Brucella suis 1330

Victor ID 1098
Gene Name dut from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167368
NCBI Protein GI 23502533
Locus Tag BR1675
Protein Accession NP_698660.1
Other Database IDs UniProtKB-ID: DUT_BRUSU
UniRef100: UniRef100_B2S7B5
UniRef90: UniRef90_B2S7B5
UniRef50: UniRef50_B2S7B5
UniParc: UPI000012996B
EMBL: AE014291
EMBL-CDS: AAN30575.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR1675
TIGR: BR1675
HOGENOM: HBG436079
OMA: LDLRACI
ProtClustDB: PRK00601
BioCyc: BSUI204722:BR_1675-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1619157
Gene Ending Position 1619630
Gene Strand (Orientation) -
Protein Name deoxyuridine 5'-triphosphate nucleotidohydrolase
DNA Sequence 
>gi|56968325:1619157-1619630 Brucella suis 1330 chromosome I, complete sequence
CTCAGGCTGTGCCGGTGGAACCGAACCCGCCCGCGCCGCGGGCTGTTTCACTTATCTTGGCGCGTTCCTC
GATTTTCGGCTGGATGACCGGAGCGAACACGGCCTGTGCGATGCGCATTCCGCGCTCGATGCGGAAATCG
TCATCTCCAAGATTGATCAGCAGGACTTTTACTTCGCCGCGATAATCCGAATCGATCGTGCCGGGCGTGT
TGAGGCAGGTTATGCCATTCTTGAAGGCAAGGCCCGAGCGGGGGCGGATCTGTACTTCATAGCCTTGCGG
GATTTCAAGGATAAGGCCGGTTGGCACCAGCGTGCGGCGGCCGGGCAAGAGCACGATCTGGCGATCTTCA
GCCACGGCGGCGCGCAGGTCCATGCCCGCCGAACCGGCGGTTTCATAGGCGGGAAGATCAAGGCCCTTCG
CATGTTCGAGGCGAATGATGCCGAGCGTTGGCGCGGAAGAGGATGCTGCGGTCA
Protein Sequence 
>gi|23502533|ref|NP_698660.1| deoxyuridine 5'-triphosphate nucleotidohydrolase [Brucella suis 1330] MTAASSSAPTLGIIRLEHAKGLDLPAYETAGSAGMDLRAAVAEDRQIVLLPGRRTLVPTGLILEIPQGYEVQIRPRSGLAFKNGITCLNTPGTIDSDYRGEVKVLLINLGDDDFRIERGMRIAQAVFAPVIQPKIEERAKISETARGAGGFGSTGTA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)(UniProt: P64005).

CATALYTIC ACTIVITY: dUTP + H(2)O = dUMP + diphosphate(UniProt: P64005).

PATHWAY: De novo synthesis of thymidylate(UniProt: P64005).

SIMILARITY: Belongs toMUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis dut gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002). the dUTPase family(UniProt: P64005).
COG COG0756F, under F: Nucleotide transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].