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pth from Brucella suis 1330

Victor ID 1093
Gene Name pth from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167219
NCBI Protein GI 23502404
Locus Tag BR1536
Protein Accession NP_698531.1
Other Database IDs UniProtKB-ID: PTH_BRUSU
UniRef100: UniRef100_A9M6K1
UniRef90: UniRef90_Q2YLX5
UniRef50: UniRef50_Q2YLX5
UniParc: UPI0000057CCB
EMBL: AE014291
EMBL-CDS: AAN30446.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR1536
TIGR: BR1536
HOGENOM: HBG610927
OMA: AMHRLHS
ProtClustDB: PRK05426
BioCyc: BSUI204722:BR_1536-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1486183
Gene Ending Position 1486935
Gene Strand (Orientation) +
Protein Name peptidyl-tRNA hydrolase
DNA Sequence 
>gi|56968325:1486183-1486935 Brucella suis 1330 chromosome I, complete sequence
CATGCTGCTCATCGCAGGTCTTGGCAATCCGGGTCCCCAATATGCGCATAACCGGCACAATATCGGTTTC
ATGGCGGCGGATGAAATATTCCGCCGCCATCGCTTTTCCAACTGGCAGAAGAAATTTCAGGCAGAGATCG
CCGATGGCGTGATCGACGGCGAGAAAGTGTTGCTGGTCAAACCGCAGACTTTCATGAACCTTTCCGGCCA
GTCTATCGGCGAGGCCATGCGCTTCTACAAGCTGACGCCTGCCGATCTCGTCGTGATCTATGATGAACTG
GACCTCGTTCCGGGCAAGCTGCGCATCAAGACCGGCGGCGGTTCCGGCGGCCATAACGGCATCAAATCCA
TCGACGCACATATGCAGTCCTTCCCCGGCGGACAGAATTATCGCCGCATGCGGCTTGGCATCGGCCATCC
CGGCGCGAAGGAACTCGTGCATAATTATGTTCTGGGCGATTTCGCCAAGGCCGACAATGAATGGCTGGAT
ACGCTTATGGGCGCCGTCGCCGACAATGTCGCCATGCTTGCCAGACGCGAGGATAACAGCTTCATGAACC
GCATTGCACTCGCCATGGGCGACGGCAATCAGCGGCCAGGCGGCGTCAAGACAGATCCCGCGCAATTGGA
GAAGGCTCCGCCAAAGGCCCAGAGCCATATTCGTCAGGCGCGCCAGAACCAGAAAAAGCCCAATATTCCC
GAAAGCGGCCCGATGGCTGAAATGCTGAAAAAGCTGCTGGGGAAGAAGGATTA
Protein Sequence 
>gi|23502404|ref|NP_698531.1| peptidyl-tRNA hydrolase [Brucella suis 1330] MLLIAGLGNPGPQYAHNRHNIGFMAADEIFRRHRFSNWQKKFQAEIADGVIDGEKVLLVKPQTFMNLSGQSIGEAMRFYKLTPADLVVIYDELDLVPGKLRIKTGGGSGGHNGIKSIDAHMQSFPGGQNYRRMRLGIGHPGAKELVHNYVLGDFAKADNEWLDTLMGAVADNVAMLARREDNSFMNRIALAMGDGNQRPGGVKTDPAQLEKAPPKAQSHIRQARQNQKKPNIPESGPMAEMLKKLLGKKD
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis (By similarity)(UniProt: P65864).

CATALYTIC ACTIVITY: N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA(UniProt: P65864).

SUBUNIT: Monomer (By similarity)(UniProt: P65864).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: P65864).

SIMILARITY: Belongs to the PTH family(UniProt: P65864).

MUTATION: pth encodes for a peptidyl tRNA hydrolase. Transposon insertion in pth has a polar effect on dugA expression and that the pth/dugA mutant is deficient in iron assimilation because of altered expression of the dugA gene. Only minor difference in intracellular growth in bovine macrophages and HeLa cells between the pth/dugA mutant and wild-type strains was observed (Danese et al., 2004).
COG COG0193J, under J: Translation, ribosomal structure and biogenesis
References
Danese et al., 2004: Danese I, Haine V, Delrue RM, Tibor A, Lestrate P, Stevaux O, Mertens P, Paquet JY, Godfroid J, De Bolle X, Letesson JJ. The Ton system, an ABC transporter, and a universally conserved GTPase are involved in iron utilization by Brucella melitensis 16M. Infection and immunity. 2004; 72(10); 5783-5790. [PubMed: 15385478].