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ilvC from Brucella suis 1330

Victor ID 1086
Gene Name ilvC from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1167062
NCBI Protein GI 23502251
Locus Tag BR1380
Protein Accession NP_698378.1
Other Database IDs UniProtKB-ID: ILVC_BRUSU
UniRef100: UniRef100_A9M637
UniRef90: UniRef90_B2S6K5
UniRef50: UniRef50_A9M177
UniParc: UPI00000DD594
EMBL: AE014291
EMBL-CDS: AAN30293.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR1380
NMPDR: fig|204722.1.peg.1335
TIGR: BR1380
HOGENOM: HBG286525
OMA: MAYAKGI
ProtClustDB: PRK05479
BioCyc: BSUI204722:BR_1380-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1335435
Gene Ending Position 1336454
Gene Strand (Orientation) -
Protein Name ketol-acid reductoisomerase
DNA Sequence 
>gi|56968325:1335435-1336454 Brucella suis 1330 chromosome I, complete sequence
ATCAGTTGCGGGCTTTATCGACCAGTTTGTTCTTTTCGATCCACGGCATCATGGCGCGTAGCTTGCCACC
GACTTCTTCGATCTGATGGGCGTCGTTGAGACGGCGGATACCCTTGAAGCGGGCAGCGCCGGCTTTCCAT
TCCTGCATCCAGTCAGAGGTGAACTTGCCGGTCTGGATATCCTTCAGAACACGCTTCATTTCGGCCTTGG
TTTCGGCGGTGATGATGCGCGGGCCGGTCACATATTCGCCCCACTCGGCAGTGTTGGAGATCGAATAGTT
CATGTTGGCAATGCCGCCTTCGTAGATCAGGTCCACGATCAGCTTCATTTCGTTCAGGCACTCGAAATAG
GCCATTTCCGGCGCATAGCCAGCTTCGACCAGAACTTCAAAGCCGGTGCGGATCAGCTCGACCACGCCGC
CGCACAGAACAGCCTGTTCGCCGAAGAGATCGGTTTCGCACTCTTCCTTGAAGGTCGTCTCGATAACGCC
CGAACGGCCGCCGCCAACGCCCGAAGCGTAGGAAAGGGCCAGATCATGGGCATTGCCAGATGCATCCTGA
TGAATGGCGATGAGGCAGGGAACGCCGCCGCCCTTCTGATATTCACCGCGAACCGTGTGGCCGGGACCCT
TCGGCGCGATCATCACGACATCAACCGTCTTCTTCGGCTCAATCAGGCCGAAATGCACGTTGAGGCCATG
GGCAAAAGCAATCGCAGCGCCATCGCGCAGATTGTTGTGGATGTGGTCGCGGTAGATGTCGGCCTGCAAT
TCGTCAGGGGTCGCCATCATCATGAGGTCGGCCCACTTGGCGGCATCGGCGACGTTCATGACTTCAAAGC
CATCGGCCTGTGCCTTCTGGACCGTGGCGGAGCCTTCACGAAGGGCAACGCGCACATTGGCCGCGCCAGA
GTCCTTCAGGTTGAGCGCATGGGCGCGGCCCTGGCTGCCATAACCGACGATAACCACCTTCTTCGACTTG
ATCAGGTTAACGTCTGCATCCCGATCGTAATAAACGCGCA
Protein Sequence 
>gi|23502251|ref|NP_698378.1| ketol-acid reductoisomerase [Brucella suis 1330] MRVYYDRDADVNLIKSKKVVIVGYGSQGRAHALNLKDSGAANVRVALREGSATVQKAQADGFEVMNVADAAKWADLMMMATPDELQADIYRDHIHNNLRDGAAIAFAHGLNVHFGLIEPKKTVDVVMIAPKGPGHTVRGEYQKGGGVPCLIAIHQDASGNAHDLALSYASGVGGGRSGVIETTFKEECETDLFGEQAVLCGGVVELIRTGFEVLVEAGYAPEMAYFECLNEMKLIVDLIYEGGIANMNYSISNTAEWGEYVTGPRIITAETKAEMKRVLKDIQTGKFTSDWMQEWKAGAARFKGIRRLNDAHQIEEVGGKLRAMMPWIEKNKLVDKARN
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: (R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH(UniProt: Q8FZU1).

CATALYTIC ACTIVITY: (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH(UniProt: Q8FZU1).

PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2(UniProt: Q8FZU1).

PATHWAY: Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2(UniProt: Q8FZU1).

SIMILARITY: Belongs to the ketol-acid reductoisomerase family(UniProt: Q8FZU1).

MUTATION: ilvC is one of the 37 mutants with virulene defect, screened out from the signature- tagged miniTn5 library (Lestrate et al., 2003).
COG COG0059EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].