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uppS from Brucella suis 1330

Victor ID 1080
Gene Name uppS from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166834
NCBI Protein GI 23502036
Locus Tag BR1158
Protein Accession NP_698163.1
Other Database IDs UniProtKB-ID: UPPS_BRUSU
UniRef100: UniRef100_Q8G0D9
UniRef90: UniRef90_Q57CY1
UniRef50: UniRef50_Q8G0D9
UniParc: UPI00000DD4F4
EMBL: AE014291
EMBL-CDS: AAN30078.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR1158
NMPDR: fig|204722.1.peg.1120
TIGR: BR1158
HOGENOM: HBG627837
OMA: RVRWAGR
ProtClustDB: PRK14834
BioCyc: BSUI204722:BR_1158-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1138126
Gene Ending Position 1138890
Gene Strand (Orientation) -
Protein Name undecaprenyl diphosphate synthase
DNA Sequence 
>gi|56968325:1138126-1138890 Brucella suis 1330 chromosome I, complete sequence
TCTAGACTGCCGCTCCCTTGGTCGAAGGGCATAATATTTCTTCTTCGGCATCCGCACTGGCGCGCGGCTC
CACACCGCCAAAACGACGCTCGCGCTGCCGGAACGTTTCATAGGCCGCATCAAGGTCGGTCGGCCGGAAA
TCCGGCCAGTGACATGGCAGAAAGAGAAACTCGGAATAGGCAGCCTGCCAGAGAAGAAAGTTGGAAAGCC
GCATCTCGCCACTGGTGCGGATGATGAGGTCGGGATCAGGTATTCCCGCCGTATCAAGATTAGCGGAAAC
AAGCTCCGCCGAGATCGAGGATGGATCAAGAAGCCCGGCGGCGACATCGCGCGCAAGGCTTCTGACCGCA
CGAACAATCTCATCGCGTGAACCGTAATTGAAGGCAATCACGAGATTGAGGCCGGTATTGCGATGGGTAA
GCGATTCCGCTTCGTTCAACAGTGCACGGATATCGGCTGCGAGCTCCGCCCGCTCGCCGATAATATTGAC
ACGCACATTGTTGCGGTGAAGCTCTGCCAGATCGCGCCGGATGAAGAGCTTCAAAAGCCCCAGAAGATCG
CTGACCTCGCCGCTCGGACGGGTCCAGTTTTCGGAAGAGAAAGCAAAAAGCGTAAGATAGCCGAGGCCGC
GATCTCCCGCGGCCCGCACGATCTCCCGCAAGGCCTCCACGCCCGCGCGGTGCCCCGCGCTGCGCGGCAA
GCCGCGCGCCTTAGCCCAACGGCCGTTGCCATCCATGATAATGGCTATGTGGCGCGGATCGGACA
Protein Sequence 
>gi|23502036|ref|NP_698163.1| undecaprenyl pyrophosphate synthase [Brucella suis 1330] MSDPRHIAIIMDGNGRWAKARGLPRSAGHRAGVEALREIVRAAGDRGLGYLTLFAFSSENWTRPSGEVSDLLGLLKLFIRRDLAELHRNNVRVNIIGERAELAADIRALLNEAESLTHRNTGLNLVIAFNYGSRDEIVRAVRSLARDVAAGLLDPSSISAELVSANLDTAGIPDPDLIIRTSGEMRLSNFLLWQAAYSEFLFLPCHWPDFRPTDLDAAYETFRQRERRFGGVEPRASADAEEEILCPSTKGAAV
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide (By similarity)(UniProt: Q8G0D9).

CATALYTIC ACTIVITY: Di-trans,poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans,poly-cis-undecaprenyl diphosphate(UniProt: Q8G0D9).

COFACTOR: Magnesium (By similarity)(UniProt: Q8G0D9).

SUBUNIT: Homodimer (By similarity)(UniProt: Q8G0D9).

SIMILARITY: Belongs to the UPP synthetase family(UniProt: Q8G0D9).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis uppS gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0020I, under I: Lipid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].