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ntrC from Brucella suis 1330

Victor ID 1078
Gene Name ntrC from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166793
NCBI Protein GI 23501995
Locus Tag BR1117
Protein Accession NP_698122.1
Other Database IDs UniProtKB-ID: Q8G0H7_BRUSU
UniRef100: UniRef100_A5VQP1
UniRef90: UniRef90_A5VQP1
UniRef50: UniRef50_Q04848
UniParc: UPI00000DD4CF
EMBL: AE014291
EMBL-CDS: AAN30037.1
RefSeq_NT: NC_004310.3
HSSP: P11028
GenomeReviews: AE014291_GR
KEGG: bms:BR1117
TIGR: BR1117
HOGENOM: HBG740884
OMA: TAIKASE
ProtClustDB: CLSK898235
BioCyc: BSUI204722:BR_1117-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 1094499
Gene Ending Position 1095974
Gene Strand (Orientation) -
Protein Name nitrogen regulation protein NtrC
DNA Sequence 
>gi|56968325:1094499-1095974 Brucella suis 1330 chromosome I, complete sequence
GCTAACCGCCGGTCTTTGCGCCACGATAGATATTGACGCCGAGTTCGCGGATTTTCTTGCGCAACGTATT
CCGGTTAAGTCCTAAAAGATCGGCGGCCTTGATCTGGTTGCCGCGGGTGGCCGTCAGGCAGGCAAGGATC
AGCGGATATTCCACTTCAGCCAGAACACGCTGATAAAGCCCCGGCGGCGGCAGATCCGAACCGAACGAAG
CGAAATAGCGCTGCATGTTCTGCTCCACGGCTTGTGAAATGGAGATATTTTCCATCTCGCCGCCAGCAGC
GGCAACAACGTCCGGCTTGGCCAATTCGGCCTTGAGCTCGGTTTCGATGATTTCCGGCGCGATTTCTTCC
TGCGGATAGAGCGCGGCAAGCCTGCGCACGAGATTTTCAAGCTCGCGCACATTGCCCGGCCACGGATAGC
GCCGCATCATCTCCAGACCCGCATTGGTAATGCGCTTTTCGGGCAACCCCTCTTCCGCAGCGCGTTTGAA
GAAATGGCGCACGAGATCGGGGACATCCTCGCTTCGTTCGCGAAGCGGCGGCAGGCGCAGCGGCACTACA
TTCAAGCGGTAGTAGAGGTCTTCGCGGAAAAGCCCCTGCGCGATGATCTGTCGTAAATCCCTGTTGGTGG
CGGCAACGATGCGCACATCGGTCTTGATCGGCGTGCGCCCGCCAACGGTCATATATTCGCCCTGTTGCAG
CACGCGCAGAAGGCGCGTTTGCGCCTCCATCGGCATATCGCCAATTTCGTCCAGAAACAGCGTACCGCCA
TTGGCCTGCTCAAAGCGCCCGCTCGACCGGTTCTGTGCGCCGGTGAATGCTCCCTTTTCGTGCCCGAACA
GTTCCGATTCGATAAGGTCACGCGGGATTGCAGCCATATTGATCGCCACGAACGGTCCCTTGCGGCGGCG
GCCATATTCATGCAGGGCACGCGCGACGAGTTCCTTGCCGGTGCCGGATTCACCCGTCACCATGACGGTG
AGGTCTGTCTGCATCATGCGCGCCAGAAGACGGTAGATTTCCTGCATGGCGGGCGAACGGCCCACAAGGG
GCATGTTCTCACCCTGCTCGTCGGGAAGCGCCACGGCAGGCTTCTGCCTGGGTTCCGAGAGCGCGCGCCC
TACGATATTGATAAGCTCGGTCAGATCGAACGGCTTTGGCAGATACTCATAAGCCCCCGCCTCGGAAGCG
CGGATTGCGGTCATGAATGTGTTCTGCGCGCTCATGACCACAACGGGCAGATCGGGGCGTATCTTCTTGA
TGCGCGGCAAGAGATCGAATGCATTTTCATCGGGCATCATGACATCGCTGATCACCAGATCGCCATCGCC
CGCCGCAACCCAGCGCCAGAGCGATGCGGCATTGGACGTCACCCGCACATCATAACCAGCACGGGACAAT
GCCTGATTGAGCACCGTGCGAATGGCTGCATCGTCGTCTGCCACCAGTACAGTTCCAGTCGGACGCCCTG
CAATCA
Protein Sequence 
>gi|23501995|ref|NP_698122.1| nitrogen regulation protein NtrC [Brucella suis 1330] MIAGRPTGTVLVADDDAAIRTVLNQALSRAGYDVRVTSNAASLWRWVAAGDGDLVISDVMMPDENAFDLLPRIKKIRPDLPVVVMSAQNTFMTAIRASEAGAYEYLPKPFDLTELINIVGRALSEPRQKPAVALPDEQGENMPLVGRSPAMQEIYRLLARMMQTDLTVMVTGESGTGKELVARALHEYGRRRKGPFVAINMAAIPRDLIESELFGHEKGAFTGAQNRSSGRFEQANGGTLFLDEIGDMPMEAQTRLLRVLQQGEYMTVGGRTPIKTDVRIVAATNRDLRQIIAQGLFREDLYYRLNVVPLRLPPLRERSEDVPDLVRHFFKRAAEEGLPEKRITNAGLEMMRRYPWPGNVRELENLVRRLAALYPQEEIAPEIIETELKAELAKPDVVAAAGGEMENISISQAVEQNMQRYFASFGSDLPPPGLYQRVLAEVEYPLILACLTATRGNQIKAADLLGLNRNTLRKKIRELGVNIYRGAKTGG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ntrC encodes for a response regulator subfamily (NtrC). A B suis ntrC isogenic mutant was constructed which showed no significant differences in growth rates compared to the wild-type strain when grown at different temperatures in vitro. However, the mutant exhibited a reduction in metabolic activity in the presence of many amino acids. The mutation did not affect survival or multiplication of B suis in macrophages, but during the initial stages of infection in the murine brucellosis model, the ntrC mutant showed a reduced ability to multiply rapidly in splenic tissue (Dorrell et al., 1999).
COG COG2204T, under T: Signal transduction mechanisms
References
Dorrell et al., 1999: Dorrell N, Guigue-Talet P, Spencer S, Foulonge V, O'Callaghan D, Wren BW. Investigation into the role of the response regulator NtrC in the metabolism and virulence of Brucella suis. Microbial pathogenesis. 1999; 27(1); 1-11. [PubMed: 10373105].