Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

glyA from Brucella suis 1330

Victor ID 1062
Gene Name glyA from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166430
NCBI Protein GI 23501652
Locus Tag BR0765
Protein Accession NP_697779.1
Other Database IDs UniProtKB-ID: GLYA_BRUSU
UniRef100: UniRef100_A9MAE5
UniRef90: UniRef90_A6X1Y9
UniRef50: UniRef50_A4SFY3
UniParc: UPI00000DD3C5
EMBL: AE014291
EMBL-CDS: AAN29694.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0765
NMPDR: fig|204722.1.peg.736
TIGR: BR0765
HOGENOM: HBG301263
OMA: CEGLEMI
ProtClustDB: PRK00011
BioCyc: BSUI204722:BR_0765-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 750665
Gene Ending Position 751981
Gene Strand (Orientation) +
Protein Name serine hydroxymethyltransferase
DNA Sequence 
>gi|56968325:750665-751981 Brucella suis 1330 chromosome I, complete sequence
CATGTCTCAAGCCAACGCCGCCACGAAAGCGTCTTCGGACGTTTTCTTCAATGCAAGCCTCGAGGACATC
GATCCCGAGATTTTCGGTGCAATCCGCAACGAACTTGGTCGCCAGCGCCATGAAATCGAGCTGATCGCTT
CGGAAAACATCGTTTCGCGCGCTGTTCTGGAAGCACAGGGTTCCATCCTCACCAACAAATATGCCGAAGG
CTATCCGGGCAAGCGCTATTATGGCGGCTGCCAGTATGTCGATGTCGTGGAAGAACTGGCGATCGAACGC
GCCAAGAAGCTTTTCAGTGCCGAATTCGCCAATGTTCAGCCGAATTCCGGCAGCCAGATGAATCAGGCGG
TTTTCCTCGCGCTGCTTCAGCCAGGCGATACCTTCATGGGCCTCGACCTTAATTCAGGTGGCCACCTGAC
CCACGGTTCGCCGGTCAATATGTCCGGCAAGTGGTTCAATGTCGTGTCCTACGGCGTGCGCAAGGACGAT
CATCTGCTCGACATGGACGAAGTCGCCCGCCTCGCACGCGAAAACAAGCCCAAGCTTATCCTTGCAGGCG
GCACGGCCTATTCGCGTATCTGGGACTGGAAGCGTTTCCGCGAGATCGCCGATGAAGTGGGCGCTTATCT
CATGGTCGATATGGCGCATATTGCCGGTCTCGTGGCTGGCGGTCAGCATCCGTCGCCGGTTCCCCATGCC
CATGTCTGCACCACGACAACGCACAAATCGCTTCGCGGTCCGCGCGGCGGCATGATCCTCACCAATGATG
CCGATATTGCCAAGAAGATCAATTCGGCTGTCTTCCCCGGCCTTCAGGGCGGCCCGCTGATGCATGTCAT
CGCCGGTAAGGCTGTTGCCTTTGCCGAGGCGTTGAAGCTTGAGTTCAAGCTCTATGCGAAGAATGTGGTG
GATAACGCCCGTGCGCTTGCCGAGGAATTGAAGTCGCACGGCCTCGACATTGTTTCGGGCGGCACCGACA
ACCATCTCATGCTGGTCGATCTGCGCCCGAAGAACGCAACCGGCAAGCGGGCGGAAGCCGCTCTCGGACG
CGCCAACATCACCTGCAACAAGAACGGCATTCCCTTCGACCCTGAAAAGCCGTTTGTGACCTCCGGCGTC
CGTCTTGGCACGCCTGCCGGCACCACGCGCGGCTTCGGCGTTGCGGAATTCAAGGAAATCGGTTCGCTGA
TCGCCGAGGTTCTCGACGGTTTGAAGGTCGCCAATTCCGACGAAGGCAATGCGGCTGTCGAACAGGCCGT
GAAGGAAAAGGTCATCGCCCTGACCGGCCGTTTCCCGATGTACGGCTATCAGGGATA
Protein Sequence 
>gi|23501652|ref|NP_697779.1| serine hydroxymethyltransferase [Brucella suis 1330] MSQANAATKASSDVFFNASLEDIDPEIFGAIRNELGRQRHEIELIASENIVSRAVLEAQGSILTNKYAEGYPGKRYYGGCQYVDVVEELAIERAKKLFSAEFANVQPNSGSQMNQAVFLALLQPGDTFMGLDLNSGGHLTHGSPVNMSGKWFNVVSYGVRKDDHLLDMDEVARLARENKPKLILAGGTAYSRIWDWKRFREIADEVGAYLMVDMAHIAGLVAGGQHPSPVPHAHVCTTTTHKSLRGPRGGMILTNDADIAKKINSAVFPGLQGGPLMHVIAGKAVAFAEALKLEFKLYAKNVVDNARALAEELKSHGLDIVSGGTDNHLMLVDLRPKNATGKRAEAALGRANITCNKNGIPFDPEKPFVTSGVRLGTPAGTTRGFGVAEFKEIGSLIAEVLDGLKVANSDEGNAAVEQAVKEKVIALTGRFPMYGYQG
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Interconversion of serine and glycine(UniProt: Q8G1F1).

CATALYTIC ACTIVITY: 5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine(UniProt: Q8G1F1).

COFACTOR: Pyridoxal phosphate (By similarity)(UniProt: Q8G1F1).

PATHWAY: Key enzyme in the biosynthesis of purines, lipids, hormones and other components(UniProt: Q8G1F1).

SUBUNIT: Homotetramer (By similarity)(UniProt: Q8G1F1).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G1F1).

SIMILARITY: Belongs to the SHMT family(UniProt: Q8G1F1).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis glyA gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0112E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].