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purM from Brucella suis 1330

Victor ID 1060
Gene Name purM from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166373
NCBI Protein GI 23501597
Locus Tag BR0710
Protein Accession NP_697724.1
Other Database IDs UniProtKB-ID: PUR5_BRUSU
UniRef100: UniRef100_B2S4W8
UniRef90: UniRef90_A6X235
UniRef50: UniRef50_A6X235
UniParc: UPI00000DD393
EMBL: AE014291
EMBL-CDS: AAN29639.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0710
TIGR: BR0710
HOGENOM: HBG531222
OMA: HYDLAGF
ProtClustDB: PRK05385
BioCyc: BSUI204722:BR_0710-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 696583
Gene Ending Position 697662
Gene Strand (Orientation) -
Protein Name phosphoribosylaminoimidazole synthetase
DNA Sequence 
>gi|56968325:696583-697662 Brucella suis 1330 chromosome I, complete sequence
TTCATAGTGCGAGCTGGCCCTTGTAGATGACGCCGTCTTTCTCACGCCGGGTCATGCGGCCGAGTGTAAC
GACCTTTTCGCCTTCGGCTGCAAGTGCTGCGATCACTTCATCGACCTTTGCCGGATTGACGACCGCAATC
ATGCCGATGCCGCAATTGAAGGTGCGCAGCATTTCATTCGGTTCGACATTGCCAGTCTTGGCAAGCCAGG
AGAAAACTGGCGGGACTGCAATGGCCGGAAGATCAATCTCCGCAGCCAGGCCTTTCGGCAGGACGCGGGG
AATATTGTCGGGGAAGCCGCCGCCTGTAATATGCGCCAGCGCCTTGATGCCGTCGCAGGCACGGATGGCG
GCGAGCAGCGGCTTGACGTAAATCCGCGTCGGGGTGAGCAGGGCTTCACCGAGCGTTGCGCCCGGTTGGA
AAGGGGCCTGCGACTTCCAGCCGAGGCCGGAAAGCTCGACGATGCGGCGCACAAGCGAGAAGCCGTTGGA
ATGAACGCCCGAGGAAGCAAGGCCCAGAATGATGTCGCCTTCGGCAATATCGCCGCGCGGCAGCAGGCGG
TCACGTTCTGCTGCGCCCACGGCAAAACCTGCAAGATCGTAATCGCCGTCGCGATACATGCCCGGCATTT
CCGCCGTCTCACCGCCGATCAGTGCGCAGCCCGCCTGACGGCAGCCTTCCGCGATGCCCGAAACGATCGC
GACGCCCTGATCCGGCGAAAGCTTGCCGGTGGCGTAATAATCGAGAAAGAAAAGCGGTTCCGCGCCCTGC
ACGACCAGATCGTTCACGCACATCGCCACGAGATCGATGCCGACAGTATCATGGATATCCGCATCAATAG
CGATCTTGAGCTTGGTGCCGACACCATCATTGGCCGCAACCAGAACCGGATCCTTGAAGCCCGCAGCCTT
GAGATCGAACAAACCGCCGAACCCGCCGATTTCGCCATCCGCACCGGGGCGGCGTGTCGAGCGCACCAAT
GGCTTGATCTTTTCGACCATCAGGTTGCCGGCATCGATATCAACACCAGCCTGCGCATAGGTCAGGCCGT
TTTGGCCGGCGGGCTTGTTTTCCATGGTCA
Protein Sequence 
>gi|23501597|ref|NP_697724.1| phosphoribosylaminoimidazole synthetase [Brucella suis 1330] MTMENKPAGQNGLTYAQAGVDIDAGNLMVEKIKPLVRSTRRPGADGEIGGFGGLFDLKAAGFKDPVLVAANDGVGTKLKIAIDADIHDTVGIDLVAMCVNDLVVQGAEPLFFLDYYATGKLSPDQGVAIVSGIAEGCRQAGCALIGGETAEMPGMYRDGDYDLAGFAVGAAERDRLLPRGDIAEGDIILGLASSGVHSNGFSLVRRIVELSGLGWKSQAPFQPGATLGEALLTPTRIYVKPLLAAIRACDGIKALAHITGGGFPDNIPRVLPKGLAAEIDLPAIAVPPVFSWLAKTGNVEPNEMLRTFNCGIGMIAVVNPAKVDEVIAALAAEGEKVVTLGRMTRREKDGVIYKGQLAL
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole(UniProt: Q8G1K5).

PATHWAY: Nucleotide biosynthesis; IMP biosynthesis; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2(UniProt: Q8G1K5).

PATHWAY: Context: Purine biosynthesis(UniProt: Q8G1K5).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G1K5).

SIMILARITY: Belongs to the AIR synthase family(UniProt: Q8G1K5).

MUTATION: B. abortus purM gene is essential for intracellular growth in HeLa cells as shown from transposon mutagenesis study (Kim et al., 2003).
COG COG0150F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].