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pepN from Brucella suis 1330

Victor ID 1056
Gene Name pepN from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166279
NCBI Protein GI 23501504
Locus Tag BR0617
Protein Accession NP_697631.1
Other Database IDs UniProtKB-ID: Q8G1T7_BRUSU
UniRef100: UniRef100_Q8G1T7
UniRef90: UniRef90_B2SAA2
UniRef50: UniRef50_B8IP01
UniParc: UPI00000DD34F
EMBL: AE014291
EMBL-CDS: AAN29546.1
RefSeq_NT: NC_004310.3
MEROPS: M01.005
GenomeReviews: AE014291_GR
KEGG: bms:BR0617
NMPDR: fig|204722.1.peg.588
TIGR: BR0617
HOGENOM: HBG289207
OMA: EYFHNWS
ProtClustDB: PRK14015
BioCyc: BSUI204722:BR_0617-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 612007
Gene Ending Position 614658
Gene Strand (Orientation) -
Protein Name aminopeptidase N
DNA Sequence 
>gi|56968325:612007-614658 Brucella suis 1330 chromosome I, complete sequence
ATCAGGCGAGCGTTTGGTCGATGATGTCGCGCAGATCGGTGGAGAGTTTGCCTGCGCCTGCAATGCGCGC
CAGTGCCGCGCGGGCATGTTCGCGCCGCACCTCTTCCAGCGACCGCCATGAGCGCATTGCCGTCAAAAGC
CGTGCGGAAAGCTGCGGGTTTTTCGGATCAATGGTCAGAAGCGTATCGGCGAGGAAACCATAGGCTGCAC
CATCTTGGCGGTTGAACCCGGTCGGGTTGGAAGCCGTAAATGCGCCGATGAGCGCGCGCACGCGATTTGG
ATTGTCGAGAGAAAAGAGCGGATGGCGGGTCAGTTCCCTCACTGCTTCAAGGGCCGTTTCGCCGGGGCGT
GTCGCCTGCACGATGAACCATTTGTCCATCACGAGCGCATCCTGGCCGAACGTTTGCTCGAAGGTTGCGA
GCGCCTGACGGGCTTCGCCGCTATCGCCAAAACGATGGACCAGAACGGCCAGCGCCGTGGCGCGGTCCGT
CATGTTGTCGGCTTCGACAAATTGCCTTTCTGCACGTTCAGGGCTCTTTTCCTGAACGCTGAGATAATCG
AGAAGGGCGCTACGCAAGGCACGCTTTCCCGCCGGGGCCGCATCGGGTGAAAACGCCCCTTCCTGCTTCA
GCGTGTCATAGAGCCCGGCAAATCCATCGGCATAGGCTGAAGCGATTGCTGCAATCAGATGGTTGCGGCT
GGCGAGGATTGCGTCTGGATCGACATTGTTACCCATTTCGCGCGCGATATCGCTTTCGCTCGGCAGCGTC
AGGCAAAGCGCCCGGAAAGCCGGGTCCAGGATTTCATCGAAGGCGACCTTTCCGGCCAGCGCGACGATCT
TCGGATCGGTTTCCGGCTGATGCCCGCCGCGCACACGCTTGGCGCCATCCAGAAGGGTCGCAGAGAAAAT
GCTGTTCATCGCCTGCCAGCGCGCAACGGGGTCGCTATCGTTCAGGGCAAGGAAAACCCGGTCTTCCGCC
GTGAGAGGCGCGGCGAGATTGACTGGCGCCGAAAAGCCGCGCAGCAGCGACGGCACGGGCCGGGCCTCGA
TGCCATGGAAGACGATGGTTTCGGATGGGCGGCGCAAATGGATTACGCCGTCGCGCACCTCGCCGCCTTC
CACCGACGAGGGCTGCATGTCCTTGCCGTCCGGCCCGATCAGGCCGAAGGCAATGGGTATATGCATGGGC
TTCCTGATCGACTGGCCGGGTGTCGGCGCAAGTGACTGTTCCAGCTTGATCGTGAATGTCTTCGCGGCTG
AGTCATGATGGAACCCGGCTTCCACCTTCGGTGTACCGGCCTGATCGTACCAGAGCGCGAATTGCGAGAA
ATCCTGCCCGGAAACATCGGCAAAAACCTGGATGAAATTCTCGATGGTCGCCGCATCGCCGTCATGGCGC
TCGAAATAGAGGTCCATGCCCTTGCGGAACAGCTCCGGCCCGATGATGGTGCGGATCATGCGAACGACTT
CCGAACCTTTTTCATAGACGGTTGCCGTATAGAAATTATTGATCTCGCGATATTCGCGAGGGCGCACCGG
ATGGGCAAGCGGGCCTGCATCCTCCGGGAATTGCTGCGCTTTCAGGATTTTCACCTCCGCAATGCGCTTG
ACAGGGCGCGAGCGCTGGTCGGCGGAAAATTCGTGATCGCGATAAACCGTCAGGCCTTCCTTGAGGCATA
GCTGGAACCAGTCGCGGCAGGTGATGCGGTTGCCGGTCCAGTTGTGGAAATATTCATGCGCGATAACGGC
TTCGATGCCGGCATAATCCGCATCGGTCGCGGTTTCAGGATCGGCCAGCACATATTTGTCGTTGAAGATA
TTGAGGCCCTTGTTCTCCATCGCGCCCATGTTGAAATCGGAGACGGCGACGATATTGAAAACGTTAAGGT
CATATTCGCGGCCGAATTTTTCCTCGTCCCATTTCATGGAGCGTTTCAGCGCGTCCATCGCATAAAGCGC
GCGGCCCTCCTTGCCATGTTCCACATGGATGGCGAGATCGACGGGCCGTCCAGATCGGGTTGTAAAGTGG
TCTTTCACCACGCCGAGCGAACCGGCGACGAGCGCGAAAAGATAGGAGGGTTTTGGATGCGGGTCGTGCC
AGACGGCAAAATGCCGTTCCGGCTGGCCCTCCACCATGCCGTTTTCGACAGGGTTGCCGTTTGAAAGCAG
GATGGGAGCGGCTTTGCGGTCGGCATCGACACGCACCGTATAGACCGACAGCACGTCCGGGCGGTCGTAA
AAATAGGTGATGCGACGAAAGCCTTCCGCCTCGCATTGGGTGCAATAGACGCCGCTGGAGCGGTAAAGGC
CGGAAAGCTGGCGATTGGCTGTTGGGTTCACCTCGGTCACGATCTGCAAGGTGAAGCGCACATCTTTCGG
AAGATCGCTGATGGTCAACTGGTCGGGCGTGGCCGAAAAGCTGTTGTCGGAAAGCGCCTTGCCGTCGATG
GCAAGGCTCACGAGCTTCAATTCGTCACCGTGGAGAACGAGCGGCGTACCGGCGGGCGTATCGGAGCGGC
GCTCTATGGTGAGCGTTGCGCGCACGATGGTTTTTTCCGGCTCCAGTGTGAAGTCGAGTTTCGTTTCGGG
TATGGCGTAAGGTGTCTGGCGATAATCTTCGAGACGGAAAGTATGGCCGGTTTCAGTACGCA
Protein Sequence 
>gi|23501504|ref|NP_697631.1| aminopeptidase [Brucella suis 1330] MRTETGHTFRLEDYRQTPYAIPETKLDFTLEPEKTIVRATLTIERRSDTPAGTPLVLHGDELKLVSLAIDGKALSDNSFSATPDQLTISDLPKDVRFTLQIVTEVNPTANRQLSGLYRSSGVYCTQCEAEGFRRITYFYDRPDVLSVYTVRVDADRKAAPILLSNGNPVENGMVEGQPERHFAVWHDPHPKPSYLFALVAGSLGVVKDHFTTRSGRPVDLAIHVEHGKEGRALYAMDALKRSMKWDEEKFGREYDLNVFNIVAVSDFNMGAMENKGLNIFNDKYVLADPETATDADYAGIEAVIAHEYFHNWTGNRITCRDWFQLCLKEGLTVYRDHEFSADQRSRPVKRIAEVKILKAQQFPEDAGPLAHPVRPREYREINNFYTATVYEKGSEVVRMIRTIIGPELFRKGMDLYFERHDGDAATIENFIQVFADVSGQDFSQFALWYDQAGTPKVEAGFHHDSAAKTFTIKLEQSLAPTPGQSIRKPMHIPIAFGLIGPDGKDMQPSSVEGGEVRDGVIHLRRPSETIVFHGIEARPVPSLLRGFSAPVNLAAPLTAEDRVFLALNDSDPVARWQAMNSIFSATLLDGAKRVRGGHQPETDPKIVALAGKVAFDEILDPAFRALCLTLPSESDIAREMGNNVDPDAILASRNHLIAAIASAYADGFAGLYDTLKQEGAFSPDAAPAGKRALRSALLDYLSVQEKSPERAERQFVEADNMTDRATALAVLVHRFGDSGEARQALATFEQTFGQDALVMDKWFIVQATRPGETALEAVRELTRHPLFSLDNPNRVRALIGAFTASNPTGFNRQDGAAYGFLADTLLTIDPKNPQLSARLLTAMRSWRSLEEVRREHARAALARIAGAGKLSTDLRDIIDQTLA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: A single mutation of PepN leads to a significant decrease in the growth rate, thus PepN seems to play a more prominent role than do the other proteases (Contreras-Rodriguez et al., 2003).
COG COG0308E, under E: Amino acid transport and metabolism
References
Contreras-Rodriguez et al., 2003: Contreras-Rodriguez A, Ramirez-Zavala B, Contreras A, Schurig GG, Sriranganathan N, Lopez-Merino A. Purification and characterization of an immunogenic aminopeptidase of Brucella melitensis. Infection and immunity. 2003; 71(9); 5238-5244. [PubMed: 12933870].