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aroC from Brucella suis 1330

Victor ID 1038
Gene Name aroC from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166089
NCBI Protein GI 23501329
Locus Tag BR0428
Protein Accession NP_697456.1
Other Database IDs UniProtKB-ID: AROC_BRUSU
UniRef100: UniRef100_B2S9R7
UniRef90: UniRef90_B2S9R7
UniRef50: UniRef50_Q2Y7L8
UniParc: UPI00000580C8
EMBL: AE014291
EMBL-CDS: AAN29371.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0428
TIGR: BR0428
HOGENOM: HBG292336
OMA: SRFTTQR
ProtClustDB: PRK05382
BioCyc: BSUI204722:BR_0428-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 428121
Gene Ending Position 429215
Gene Strand (Orientation) +
Protein Name chorismate synthase
DNA Sequence 
>gi|56968325:428121-429215 Brucella suis 1330 chromosome I, complete sequence
CATGTCTCATAATAGTTTCGGTCATCTGTTCCGCGTAACCACCTGGGGCGAAAGCCACGGTCTGGCGCTT
GGTTGCGTCGTGGATGGCTGCCCCCCCGGAATTACCTTCACCGAAGCCGAAATCCAGTCCTTTCTCGACA
AGCGCAAGCCGGGCCAGTCGAAATATACCACGCAGCGCCGCGAGCCGGATCAGGTGCGCGTGCTTTCCGG
CGTGCTTCTGGGCGAGGATGGTGTGACCATGACCACCACCGGCACGCCCATCTCCATGATGATCGAAAAT
ACCGATCAGCGTTCCAAGGATTATGGCGAGATCGCCCGGCAATACCGTCCCGGCCATGCCGATTACGCCT
ATGATGTGAAATATGGCATTCGTGATTATCGCGGCGGCGGACGGTCTTCCGCACGCGAAACGGCGGCGCG
TGTGGCGGCGGGTGCCATTGCCCGCAAGGTCGTTCCGGGACTGGAAGTCAGGGGCGCACTCGTTTCCATC
GGTGCGCACGATATCGACCGCAGCCGCTGGAACTGGGCGGAAGTGGACAATAATCCCTTCTTCACGCCGG
ATGCCGGTTCGGTGGAGGTTTTCGCCGACTATCTCGACGGTATCCGCAAGAACGGCTCATCGGTCGGTGC
GATCATCGAAATCGTGGCCGAGGGTGTACCGGCTGGCATCGGTGCGCCGATCTACGGCAAGCTGGATCAG
GATATCGCGAGCTATCTCATGTCGATCAACGCCGTGAAGGGCGTGGAAATCGGCAATGGCTTCGAGGCTG
CGCGCCTCACCGGCGAGGAAAATGCCGATGAAATGCGCATGGGCAATGACGGCAAGCCGATTTTTCTTTC
CAATCATGCGGGCGGTGTTCTGGGCGGCATAGCAACGGGCGCGCCGGTGGTGGCGCGTTTTGCGGTCAAG
CCAACGTCATCGATCCTCACGCCGCGCCGTTCCATCGATAAGGACGGCAATGAGGTTGATGTGATGACGA
GGGGCCGTCACGATCCGTGCGTGGGCATCCGCGCCGTGCCGATCGGTGAGGCCATGGTTGCCTGCGCCAT
TGCCGATCACTATCTGCGCCACCGCGGCCAGACTGGCCGCGTCTG
Protein Sequence 
>gi|23501329|ref|NP_697456.1| chorismate synthase [Brucella suis 1330] MSHNSFGHLFRVTTWGESHGLALGCVVDGCPPGITFTEAEIQSFLDKRKPGQSKYTTQRREPDQVRVLSGVLLGEDGVTMTTTGTPISMMIENTDQRSKDYGEIARQYRPGHADYAYDVKYGIRDYRGGGRSSARETAARVAAGAIARKVVPGLEVRGALVSIGAHDIDRSRWNWAEVDNNPFFTPDAGSVEVFADYLDGIRKNGSSVGAIIEIVAEGVPAGIGAPIYGKLDQDIASYLMSINAVKGVEIGNGFEAARLTGEENADEMRMGNDGKPIFLSNHAGGVLGGIATGAPVVARFAVKPTSSILTPRRSIDKDGNEVDVMTRGRHDPCVGIRAVPIGEAMVACAIADHYLRHRGQTGRV
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate(UniProt: P63608).

COFACTOR: Reduced flavin (By similarity)(UniProt: P63608).

PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 7 [final step](UniProt: P63608).

PATHWAY: Context: Aromatic amino acids biosynthesis(UniProt: P63608).

SUBUNIT: Homotetramer (By similarity)(UniProt: P63608).

SIMILARITY: Belongs to the chorismate synthase family(UniProt: P63608).

MUTATION: The cloned aroC gene complements Escherichia coli and Salmonella enterica serovar Typhimurium aroC mutants. A B suis aroC mutant was found to be unable to grow in a defined medium without aromatic compounds. The mutant was highly attenuated in it issue culture (THP1 macrophages and HeLa cells) and murine virulence models (Foulongne et al., 2001).
COG COG0082E, under E: Amino acid transport and metabolism
References
Foulongne et al., 2001: Foulongne V, Walravens K, Bourg G, Boschiroli ML, Godfroid J, Ramuz M, O'Callaghan D. Aromatic compound-dependent Brucella suis is attenuated in both cultured cells and mouse models. Infection and immunity. 2001; 69(1); 547-550. [PubMed: 11119550].