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bacA from Brucella suis 1330

Victor ID 1036
Gene Name bacA from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1166033
NCBI Protein GI 23501276
Locus Tag BR0372
Protein Accession NP_697403.1
Other Database IDs UniProtKB-ID: Q8G2F1_BRUSU
UniRef100: UniRef100_A5VNV7
UniRef90: UniRef90_C0RH86
UniRef50: UniRef50_Q08120
UniParc: UPI00000AEA21
EMBL: AE014291
EMBL-CDS: AAN29318.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0372
TIGR: BR0372
HOGENOM: HBG289932
OMA: TMRFSST
ProtClustDB: PRK11098
BioCyc: BSUI204722:BR_0372-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 383820
Gene Ending Position 385067
Gene Strand (Orientation) +
Protein Name transport protein
DNA Sequence 
>gi|56968325:383820-385067 Brucella suis 1330 chromosome I, complete sequence
CGTGTTTGCGTCATTTTTCCCCCGTCCGAAACTGTTCTTCATATCTGCACTTTTGTGGACCCTGCTCGCA
GTTCTTGGCTGGTATATGGGCGGTGAAAATCTGGGCAGCGTGTTCGGCCTTGCGCCAGCCGCAAGCGATG
CCGCGCCTCTCATTGGCGCGCATGTGTTCTGGTCGCGGCCCTTCCTCTGGTTCTATATTTATTTCGCCGT
CATTACCTTCGCCTTTTATGGCTTCTGGGTGCGTTTTTCCCCACATCCCTGGCAGAGATGGTCAATCCTC
GGTTCTGCCCTCATTCTGTTCGCCACCTATTTCAACGTTCAGGTGAGTGTGGCAATCAATACTTGGTATG
GCCCGTTCTACGATATGGTGCAGAAGGGGCTGACGACGCCCGGCGCGGTCTCGGCTGCGGAATTCTACTG
GGGGCTGGCCGATTTTGCAGGCATTGCTTTCCTCGCCATCACCATTGGCGTGCTGAACCTCTTCTTCGTC
AGCCATTATATCTTCCGCTGGCGCACGGCGATGAACGATTATTACATGAGCCATTGGCCGAAATTGCGCC
ATATCGAGGGTGCGGCCCAGCGTGTGCAGGAAGATACGATGCGCTTTTCCACCACGCTGGAACAGCTGGG
CGTCAGCCTCGTGAAATCCGTCATGACCCTCATCGCCTTCCTGCCCGTCCTGTTCACCTTTTCCCAAAAG
GTCAGCACGCTGCCGATCATCGGCTATGTTCCCCATGCGCTGGTCTGGGCGGCGGTCATCTGGGCGCTGT
TCGGCACCGGCTTCCTGGCGCTGGTGGGCATCAAGCTGCCCGGTCTGGAGTTCAACAACCAGCGGGTCGA
GGCCGCCTACCGTAAGGAACTCGTCTATGGCGAAGACCATGCCGACCGTGCTGAACCGATCACGATGCGC
GAACTGTTCAAGAATGTCCGGCACAATTATTTCCGGCTTTATTTCCACTATGTCTATTTCAATGTGGCGC
GCATTTTCTATTTGCAGGTGGACAATATCTTTCCGCTCATCATCCTGATCCCGTCGATTGTCGCGGGCAA
GCTGACGCTTGGCCTGATGAGCCAGATTACCAACGTGTTCGATCAGGTGCGCGGATCGTTCCAGTATCTG
GTCAATTCATGGACGACGATCATCGAGCTTCTGTCGATCTACAAGCGCCTTCGCGCCTTTGAGGCAGCCA
TTCATGGCGAGCCGCTACAGGCGGTGGATCGGATCAATCTCGAACCAGGGGCGGGCTG
Protein Sequence 
>gi|23501276|ref|NP_697403.1| transport protein [Brucella suis 1330] MFASFFPRPKLFFISALLWTLLAVLGWYMGGENLGSVFGLAPAASDAAPLIGAHVFWSRPFLWFYIYFAVITFAFYGFWVRFSPHPWQRWSILGSALILFATYFNVQVSVAINTWYGPFYDMVQKGLTTPGAVSAAEFYWGLADFAGIAFLAITIGVLNLFFVSHYIFRWRTAMNDYYMSHWPKLRHIEGAAQRVQEDTMRFSTTLEQLGVSLVKSVMTLIAFLPVLFTFSQKVSTLPIIGYVPHALVWAAVIWALFGTGFLALVGIKLPGLEFNNQRVEAAYRKELVYGEDHADRAEPITMRELFKNVRHNYFRLYFHYVYFNVARIFYLQVDNIFPLIILIPSIVAGKLTLGLMSQITNVFDQVRGSFQYLVNSWTTIIELLSIYKRLRAFEAAIHGEPLQAVDRINLEPGAG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B abortus bacA mutant exhibited decreased survival in macrophages and greatly accelerated clearance from experimentally infected mice compared to the virulent parental strain (LeVier et al., 2000). R meliloti bacA gene encodes a putative cytoplasmic membrane transport protein required for symbiosis (LeVier et al., 2000). The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells , respectively. Mutation study showed that B. abortus BacA affects the distribution of LPS fatty acids, including a very-long-chain fatty acid thought to be unique to the alpha-proteobacteria(LeVier et al., 2000).
COG COG1133I, under I: Lipid transport and metabolism
References
LeVier et al., 2000: LeVier K, Phillips RW, Grippe VK, Roop RM 2nd, Walker GC. Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival. Science (New York, N.Y.). 2000; 287(5462); 2492-2493. [PubMed: 10741969].