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pyrD from Brucella suis 1330

Victor ID 1034
Gene Name pyrD from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165972
NCBI Protein GI 23501218
Locus Tag BR0311
Protein Accession NP_697345.1
Other Database IDs UniProtKB-ID: PYRD_BRUSU
UniRef100: UniRef100_A9M7Z9
UniRef90: UniRef90_B2S953
UniRef50: UniRef50_A5EA61
UniParc: UPI00000DD269
EMBL: AE014291
EMBL-CDS: AAN29260.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0311
NMPDR: fig|204722.1.peg.302
TIGR: BR0311
HOGENOM: HBG351027
OMA: AALNRMG
ProtClustDB: PRK05286
BioCyc: BSUI204722:BR_0311-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 323030
Gene Ending Position 324124
Gene Strand (Orientation) -
Protein Name dihydroorotate dehydrogenase 2
DNA Sequence 
>gi|56968325:323030-324124 Brucella suis 1330 chromosome I, complete sequence
TTTAAGATATAAGTTTGCGTGCGGCCCATTCCTTTGTGTCACGGTCGCGCAATTCAGCAATGCTGGAAAC
GCCTTCATGCTTGATTGCCGTGGAAAGGCCGCGCAGGATTTCACCCGGAAGGCCGGGGCCGCGATAGATC
AGCCCGGTATAAAGCTGCACCAGATCGGCGCCTGCCTTGATCTTGGCCAGCGCCGTTTCGGCACTGTCGA
TGCCGCCCACGCCGATCAGCGGCATATCGGGGCCGACGCGCTCGCGCATCCGCGCCAGAACCACGGTCGA
GCGTTCAAACAGCGGCGCACCGGAAAGCCCGCCGGTTTCATTGCTGTTTTCGGGATTTTTAAGCCCGCTT
CGCGATAGTGTCGTGTTGGAAACAATGATGCCGTCCAGCTTCTGCGCATCTGCTTCGGCGGCGATATCGT
CCAGTTCCTCATCGGTGAGATCAGGCGCAATCTTCAGGAAAACGGGCCGCTTCAGCGTGCACATATTTCC
CTCCTCGTCGCGCGCTTCCAGAACACGGCTCAAAAGCTCGTGCAGGGCCTCGCGCGCCTGGAGATTGCGC
AGCCCCGGCGTGTTGGGTGAGGAAATATTGACCGTGAAATAGCGCGCCAGCTGATAGAAGCGGCGGATAC
CGGCCACATAATCCGCGATCCGGTCTTCGGCATCCTTGTTCGCGCCGATGTTGACGCCGACAATGCCGCT
CTTGCCTGCGCGCCTGGAAAGACGCTTGAAGGCGGCTTCATGGCCCTCATTGTTGAAGCCGAGGCGGTTG
ATGACGGCCTTGTCGTCCACAAGTCGGAAAATGCGCGGGCGCGGATTGCCGCTTTGCGGGCGGGGGGTCA
GGGTGCCGACTTCCGCAAAGCCGAATCCAAGCTTCAGCAGCGCATCCGGCACTTCGGCATTCTTGTCGTA
ACCGGCAGCCATGCCGAGCGGATTGGGAAATTTCAGCCCCGCCACCTTCACCGAAAGGGCCGGATCTTCG
GGCGTGCGGCAAGTGACGATCCCGGTTTTCAGCCCGGTGATGGAAAGGCCGTGTGCCTGTTCCGCATCGA
AGGTGAAGAGGGCGCGCCGCCCCAGAGTTTCAAAAAGCCCACTCA
Protein Sequence 
>gi|23501218|ref|NP_697345.1| dihydroorotate dehydrogenase 2 [Brucella suis 1330] MSGLFETLGRRALFTFDAEQAHGLSITGLKTGIVTCRTPEDPALSVKVAGLKFPNPLGMAAGYDKNAEVPDALLKLGFGFAEVGTLTPRPQSGNPRPRIFRLVDDKAVINRLGFNNEGHEAAFKRLSRRAGKSGIVGVNIGANKDAEDRIADYVAGIRRFYQLARYFTVNISSPNTPGLRNLQAREALHELLSRVLEARDEEGNMCTLKRPVFLKIAPDLTDEELDDIAAEADAQKLDGIIVSNTTLSRSGLKNPENSNETGGLSGAPLFERSTVVLARMRERVGPDMPLIGVGGIDSAETALAKIKAGADLVQLYTGLIYRGPGLPGEILRGLSTAIKHEGVSSIAELRDRDTKEWAARKLIS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: B. suis pyrD mutation study indicated that pyrimidine synthesis pathway contributes to intracellular growth (Kim et al., 2003).
COG COG0167F, under F: Nucleotide transport and metabolism
References
Kim et al., 2003: Kim S, Watarai M, Kondo Y, Erdenebaatar J, Makino S, Shirahata T. Isolation and characterization of mini-Tn5Km2 insertion mutants of Brucella abortus deficient in internalization and intracellular growth in HeLa cells. Infection and immunity. 2003; 71(6); 3020-3027. [PubMed: 12761078].