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pgi from Brucella suis 1330

Victor ID 1033
Gene Name pgi from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165946
NCBI Protein GI 23501192
Locus Tag BR0285
Protein Accession NP_697319.1
Other Database IDs UniProtKB-ID: G6PI_BRUSU
UniRef100: UniRef100_A9M7X1
UniRef90: UniRef90_B2S928
UniRef50: UniRef50_A9M7X1
UniParc: UPI00000DD253
EMBL: AE014291
EMBL-CDS: AAN29234.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0285
NMPDR: fig|204722.1.peg.276
TIGR: BR0285
HOGENOM: HBG352954
OMA: INAQHAF
ProtClustDB: PRK00179
BioCyc: BSUI204722:BR_0285-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 293688
Gene Ending Position 295337
Gene Strand (Orientation) +
Protein Name glucose-6-phosphate isomerase
DNA Sequence 
>gi|56968325:293688-295337 Brucella suis 1330 chromosome I, complete sequence
CATGGCAAGAGACGCGACGAAGCTTGAAGCAACGGTCGCAAAGCTGAAAAAGCATTGGGCGGAATCGGCC
CCGCGCGATATGCGCGCGGCATTCAGCGCCGACCCCGGCCGGTTCGGGCGATATTCGCTCTGCCTGGATG
ATCTTCTGTTCGACTGGTCGAAGTGCCGGGTTAACGACGAGACCATGGCGCTGTTGAAAGAGCTGGCCGT
CGCTGCCGATGTGGAAGGGCGCCGCGCCGCCATGTTCGCGGGCGAGCATATCAACAATACCGAAGACCGC
GCCGTTCTGCATGTGGCGCTGCGCGACACGTCCTCGAAGGAAGTGCTGGTTGACGGGCATAATGTACTGC
CGGATGTGAAACATGTGCTCGACCGCATGGCCGCTTTTGCGGATGGCATCCGGTCCGGCGCGTTGAAGGG
CGCGACCGGCCGGAAGATTACCGATATCGTGAATATCGGCATTGGCGGTTCCGATCTGGGGCCTGTCATG
GCGACGCTGGCGCTTGCGCCCTATCATGATGGGCCACGCGCGCATTTCGTTTCCAATATCGATGGCGCGC
ATATTGCCGACACGCTTTCGCCGCTTGATCCGGCATCGACGCTTATCATTGTCGCGTCGAAGACTTTTAC
GACCATTGAAACCATGACGAACGCGCAGACGGCGCGCAAATGGGTGGCAGACACCCTGGGCGAGGCGGCG
GTGGGCGCGCATTTTGCTGCCGTTTCCACTGCGCTCGACAAGGTTGCGGCCTTCGGTATTCCTGAAGATC
GTGTTTTCGGCTTCTGGGACTGGGTTGGCGGGCGTTATTCGGTCTGGTCGGCCATCGGCCTGCCGGTGAT
GATCGCCGTCGGCCCGGATAATTTCCGCAAGTTCCTTGCGGGCGCACACGCCATGGATGTGCATTTCCGC
GATGCGCCACTGGAAAAGAACCTGCCCGTCATGCTCGGCCTCATCGGCTATTGGCATCGCGCAATCTGCG
GTTATGGCAGCCGCGCCATCATTCCTTATGACCAGCGCCTTTCGCGCCTCCCGGCCTATTTGCAGCAGCT
CGATATGGAATCGAACGGCAAGAGCGTGACGCTGGATGGCAAGCCGGTTTCCGGCCCAACCGGCCCCGTT
GTCTGGGGTGAGCCCGGCACCAATGGCCAGCACGCCTTTTTCCAGCTTCTGCATCAGGGAACCGATACGA
TCCCGCTGGAATTCATCGTGGCGGCCAAGGGCCACGAGCCGACACTGGATCACCAGCATGAAATGCTGAT
GGCAAACTGCCTTGCCCAGTCCGAAGCCCTGATGAAAGGCCGCACGCTGGACGAGGCGCGTGCGCAGTTG
CAGGCAAAGAACCTGCCTGCGTCGCAAGTGGAGCGCATTGCCCCGCACCGCGTCTTTTCCGGCAACCGCC
CATCCCTGACGCTCATCCATGACATGCTCGACCCCTATGCGCTGGGTCGCCTGATCGCGCTTTACGAACA
TCGTGTTTTCGTCGAAGCGCAGATTTTCGGCATCAATGCCTTCGATCAATGGGGCGTGGAACTGGGTAAG
GAACTGGCGACGGAACTTTTGCCGGTTGTATCGGGCAAGGAAGGGGCGAGTGGTCGCGACGCTTCCACGC
AAGGGCTTGTCGCGCATCTGCATGCGCGAAGGAAAGCTTG
Protein Sequence 
>gi|23501192|ref|NP_697319.1| glucose-6-phosphate isomerase [Brucella suis 1330] MARDATKLEATVAKLKKHWAESAPRDMRAAFSADPGRFGRYSLCLDDLLFDWSKCRVNDETMALLKELAVAADVEGRRAAMFAGEHINNTEDRAVLHVALRDTSSKEVLVDGHNVLPDVKHVLDRMAAFADGIRSGALKGATGRKITDIVNIGIGGSDLGPVMATLALAPYHDGPRAHFVSNIDGAHIADTLSPLDPASTLIIVASKTFTTIETMTNAQTARKWVADTLGEAAVGAHFAAVSTALDKVAAFGIPEDRVFGFWDWVGGRYSVWSAIGLPVMIAVGPDNFRKFLAGAHAMDVHFRDAPLEKNLPVMLGLIGYWHRAICGYGSRAIIPYDQRLSRLPAYLQQLDMESNGKSVTLDGKPVSGPTGPVVWGEPGTNGQHAFFQLLHQGTDTIPLEFIVAAKGHEPTLDHQHEMLMANCLAQSEALMKGRTLDEARAQLQAKNLPASQVERIAPHRVFSGNRPSLTLIHDMLDPYALGRLIALYEHRVFVEAQIFGINAFDQWGVELGKELATELLPVVSGKEGASGRDASTQGLVAHLHARRKA
Molecule Role Virulence factor
Molecule Role Annotation CATALYTIC ACTIVITY: D-glucose 6-phosphate = D-fructose 6-phosphate(UniProt: Q8G2N3).

PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2(UniProt: Q8G2N3).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8G2N3).

SIMILARITY: Belongs to the GPI family(UniProt: Q8G2N3).

MUTATION: B. suis pgi is a gene identified by signature-tagged mutagenesis. The mutant is attenuated inside THP1 macrophages. The mutation of the pgi gene could also affect the biosynthesis of the bacterial peptidoglycan (Foulongne et al., 2000).
COG COG0166G, under G: Carbohydrate transport and metabolism
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].