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hisD from Brucella suis 1330

Victor ID 1032
Gene Name hisD from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165911
NCBI Protein GI 23501159
Locus Tag BR0252
Protein Accession NP_697286.1
Other Database IDs UniProtKB-ID: HISX_BRUSU
UniRef100: UniRef100_Q8G2R2
UniRef90: UniRef90_Q2YPB8
UniRef50: UniRef50_Q46WL2
UniParc: UPI000012C8BF
EMBL: AE014291
EMBL-CDS: AAN29201.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0252
NMPDR: fig|204722.1.peg.243
TIGR: BR0252
HOGENOM: HBG329596
OMA: ARDRIEF
ProtClustDB: PRK00877
BioCyc: BSUI204722:BR_0252-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 261358
Gene Ending Position 262650
Gene Strand (Orientation) -
Protein Name histidinol dehydrogenase
DNA Sequence 
>gi|56968325:261358-262650 Brucella suis 1330 chromosome I, complete sequence
CTCATAGGTTCAGACGAATGGCGACGGATTGGGCATGGGCATCGAGACCCTCGGCGCGTGCAATCTCGAT
CGCAGCCGGTCCAAGTGCGCGAAGCTGCTCGGAGCCCAGCTTGAGAAGCGAGGTGCGCTTCATATAATCG
AGCACCGAAAGGCCGGAGGAGAAACGGGCAGAGCGCGCCGTTGGCAGCACATGGTTGCAGCCCCCCACAT
AATCGCCGATCACTTCCGGTGTATAACCGCCAATGAATATGGAACCGGCATTGCGGATGCGCGGTACGAA
CGCCTCCGCATCGGCCACGGCGATTTCCAGATGCTCGGCCGCAATACGGTTGGCAAGCGGAATTGCGTCC
TCGAAATCCTTGACCAGAATGACCGCACCGAAATCGCGCCAGCTTGCGGAAGCCGTTTCAGTGCGCGCCA
GGGTGTGAAGCTGCCGTTCGACCGCTTCTTCCACCGCGTGGGCAAAGGCCTCGTCATTGGTCATCAGGAT
GGATTGCGCGGCCGTATCGTGCTCGGCCTGTGCCAGAAGATCGGCGGCGATCCAGTCCGGGTTATTGTCC
TTGTCGGCCACGATCAGCACTTCGGATGGCCCGGCGATCATGTCGATGCCGACCGTTCCGAATACGATGC
GCTTTGCCGCTGCCACATAGGCATTGCCGGGGCCGACGATCTTGGCGACGGGACGGATCGTTTCGGTGCC
ATAGGCAAGGGCGGCAATGGCCTGCGCGCCGCCGACGCGGTAAATCTCCGACACGCCTGCAAGGCGGGCT
GCCACCAGCACCAGCGGATTGAGATTGCCATCGGGTGCGGGCACCACCATGACGATGCGGTCCACGCCTG
CGACCTTGGCGGGCATCGCATTCATCAGAACGGAACTTGGATAGCTGGCCGTGCCGCCAGGCACATAGAG
GCCGACAGCCTCGATGGCCGTCCAGCGCGAGCCAAGCTCGACGCCAAGCGCATCCGTATAGCGGTCGTCC
TTCGGCAACTGGCGAGCATGGTGCTTTTCGATACGGTCGCGCGCAAGCTTCAATGCTTCGACGGTGGAGG
CGGGAGCGGCATCGAATGCGGCATCGATCTCGGCCTCGGTGACGGCAATGCCGGTCTTTTCCAGATCGAT
CCGGTCGAAGCGGCGTGAATAATCGAGCAGCGCGCTGTCACCCTCGCGGCGTACACGATCCACGATTTCC
CGCACGGCGCGGTCCACATCTTCCGAAACCTCGCGCTTGCCGGAGAGGAAGGCCGCAAACTTCTGTTCAA
AATCAGGGTCGGTCTGTCTGAGCGTTGTGACCA
Protein Sequence 
>gi|23501159|ref|NP_697286.1| histidinol dehydrogenase [Brucella suis 1330] MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSRWTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTVGIDMIAGPSEVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPEVIGDYVGGCNHVLPTARSARFSSGLSVLDYMKRTSLLKLGSEQLRALGPAAIEIARAEGLDAHAQSVAIRLNL
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine (By similarity)(UniProt: Q8G2R2).

CATALYTIC ACTIVITY: L-histidinol + 2 NAD(+) = L-histidine + 2 NADH(UniProt: Q8G2R2).

COFACTOR: Binds 1 zinc ion per subunit (By similarity)(UniProt: Q8G2R2).

PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9 [final step](UniProt: Q8G2R2).

SIMILARITY: Belongs to the histidinol dehydrogenase family(UniProt: Q8G2R2).

MUTATION: A study with miniTn5 mutants of B. suis constitutively expressing gfp indicates that B. suis hisD gene is required for intracellular multiplication in human macrophage THP-1 cells (Kohler et al., 2002).
COG COG0141E, under E: Amino acid transport and metabolism
References
Kohler et al., 2002: Kohler S, Foulongne V, Ouahrani-Bettache S, Bourg G, Teyssier J, Ramuz M, Liautard JP. The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell. Proceedings of the National Academy of Sciences of the United States of America. 2002 Nov 26; 99(24); 15711-6. [PubMed: 12438693 ].