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glnD from Brucella suis 1330

Victor ID 1028
Gene Name glnD from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165801
NCBI Protein GI 23501056
Locus Tag BR0144
Protein Accession NP_697183.1
Other Database IDs UniProtKB-ID: GLND_BRUSU
UniRef100: UniRef100_Q8G312
UniRef90: UniRef90_B2S8D8
UniRef50: UniRef50_Q8UIF1
UniParc: UPI00000DD1E8
EMBL: AE014291
EMBL-CDS: AAN29098.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0144
NMPDR: fig|204722.1.peg.140
TIGR: BR0144
HOGENOM: HBG687872
OMA: MQHDLFH
ProtClustDB: PRK05092
BioCyc: BSUI204722:BR_0144-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 157604
Gene Ending Position 160408
Gene Strand (Orientation) -
Protein Name PII uridylyl-transferase
DNA Sequence 
>gi|56968325:157604-160408 Brucella suis 1330 chromosome I, complete sequence
CCTATGCTGCGGCCTGTGGCGAGCGGCCGTTTGTCCTGGCGCCGTTCTCTGCGCCCAGAAGGGCAAGGAG
CTTGCGCTTGATATTGCCCTGGCGGGTGGCGTTTGAAATCTTGTGGCCCACGAGATCCGTCACATAAAAA
CTGTCGATCACCTTCTCGCCGAAAGTGGTGATATGGGCCGAAGCGATATCCAGTGAAAGGTCGGAAATAA
GGCCGGTCAGCTCTGAAAGCAGGCCCGGCCGGTCCAGACCTTCCACTTCGATGACCGTGAATTTGTTGGA
AAGCGTGTTGTTGATCTCGACACGCGGCTCCACCTTGAAAGCCCTGGCAGCTTTCTTCGGCTTGGTGCGC
TTCGCCAGCATATCGGGCAGATGCGCCTTGCCGGAAAGCACGTCCTCGATCACCTTGCCCACGCGCTCGG
CCCGGCGGCGTTCGTCGTCGTCGGTGTCGAATTCGCGGCTGATGAGGATCGTGTCCAGCGCACGCCCGTT
GCTGGTGGTAAAAATCTGCGCATCCACGATATTGCCGCCCGCTGCCGCGCAGGCTCCGGTAATGACCGAA
AGGAGACGCGGATGGTCGGGCGCGAGAACGGTAATTTCGGTCACGGCCTCGAATGCGTGCGGCTTGGCCA
TGGTGACGAGCGCACGGCCCTGCTGGTCGGCATCGCGTATGAAATGCGCATGGCGCACCTGATCGTCCAG
GCTGACGGTGAGGAAATAATTGGTATAGGGCAGGGCAAGATAGGCGTCGCGCTCTTCCTTCGGCCAGTCG
GAAAGCCGCTCGGCCAGCGCCTCACGCGCCTGCTTGTCGCGGGCGGCCCGCGACAATTCGGAAAATCCGC
CCGTCAGCACCAGTTCGGTCTCATAGAAAAGCGTGCGCAGAAGCTGGCCTTTCCAGCCGTTCCATATGCC
GGGGCCGACCGCCTTGATATCACAAACGGTGAGGATCAGGAGAAGCTTCAGCCGCTCCATCGTCTGCACC
GTATCGGCAAAATCGATAATGGTCTTGCGGTCGTTGAGATCGCGCGATTGCGCCACCATGCTCATGGTGA
GGTGTTCGCGCACCAGCCATTCCACGGTCTCGGTTTCGGATGGTGTCAAGCCGAAGCGCGGGCAAAGCCT
GCGGGCAATGCGTGCGCCCGCGATGGAGTGGTCTTCCGGGCGGCCCTTGGCGATATCGTGCAGAAGAAGC
GTCACGTAAAGCAGGTTGCGGTCGCGCTTGATCGTGGTGATGAGATGGTTTGAAAGCGGGTGCTCGGTTT
TAAGCTCGCCGTGCTCGATTTCCGAAAGCACGGCAATGCAGCGCAACAGATGCTCGTCCACCGTATAGTG
GTGATACATATTGAACTGCATCATCGCGACGATCTTGCCGAAATCGGGAATGAATTTTCCAAGCACGCCG
GATTCGTTCATGCGGCGCAGGATAAGTTCCGGATTGCGCGGCGAGGTGAGGATTTCGAGGAAAAGCCGGT
TGGCCTCCGGGTTCTCGCGCAGGTCGGCATTGATGAGCTTCAGCGAGCGGGTGAGGCTCTGCATTGCTTC
GGGATGAAACTCCAGCCCATGGCGGTCGGCAAGGTGAAAGAGCCGGATCATATTGACCGGGTCCTGCCGG
AAAATATCGGGCCGTGCGATATTGATGCGATGGTTTTCCGAAATGAAAGCGCCATCATCCGAAAGCTTGC
GCTTGCGGCGCGAGAAGGTCAGGAAGATGCGGTTGAAGCCTGGAACATGCTTTGCCTGCTGTTCTTCCAG
CGCCGCGCAGATGATGCGGGTGAGGTCACCCACATCCTTCGCGACGAGGAAATAATGCTTCATGAAGCGT
TCGACATAGTTCTGGCCGGGATGCGCCGTATAGCCGAGGCGCTGTGCGATTTCCGGCTGAATGTCGAAGG
AAAGGCGTTCTTCGGCTTTCAGCGTCGCAAAATGCATATGGCACCGCACCGCCCAGAGAAAATCCTCAGC
CTTGTTGAACAATTTCAGTTCCGCTCGCGACAGAACCCCAAGCTTGACCAGCTCTTCCTTGGTCTTCACG
CGGTAGAAATATTTGGTGATCCAGAACAGGGTGTGCAGGTCGCGCTGTCCGCCCTTGCCTTCCTTGACGT
TCGGTTCGACCAGATAGCGTGTTTCACCTGCCTTGCGGTGGCGTGCATCGCGCTCGGCAAGCTTTGCCTG
AATGAATTCCGGCTCCGTTCCCTTGACGATTTCCTCCTCGAAACGGATTTCAAGCGTGCGGAACAGATCC
TTGTCGCCGGTAAGAAAGCGCGCATCGAGAAGGGCTGTGCGAATGGTCATGTCCTCGCGCGCCAGACGAA
TGCACTCATCGATGTTGCGGGTGGAATGGCCGACTTTCAGCCCCATGTCCCAGAGCATGTAGAGCGTATA
TTCCACAACCTGTTCGCCCCAGGGCGTCTGTTTATAGGGAAGCAGGAAAAGAAGGTCGATGTCGGAACCC
TGTGCAAGCCCGCCGCGCCCATAGCCGCCGACTGCCACGAGCGCCATATTCTCCGCCTTGGAGGGATTGC
GCGTCGGATAGGCCCTGGTGGTTGCGAATTCAAACAGGATGTCGATCAGCGTATCCATCAGGTAGCAGAG
CCGCTTGGCGCAAAGCGTGCCGCCGCCATCCTTCATCAGCATGTCTTCGGCATTGGCGCGCCCGCTCGCC
AGCGCATCCTTCAGCGTCTGGAGCACAACCTTGCGCATGGGAAGGCTGGTGTAGCTTTCATCGGCCGTGT
CCGCCAGTTCATTGAGCTTGCGACGGAGCGTTTCGGCATTGACGATCTCTTCCAGCTTCAGGTCGTGTGC
GCTCA
Protein Sequence 
>gi|23501056|ref|NP_697183.1| PII uridylyl-transferase [Brucella suis 1330] MSAHDLKLEEIVNAETLRRKLNELADTADESYTSLPMRKVVLQTLKDALASGRANAEDMLMKDGGGTLCAKRLCYLMDTLIDILFEFATTRAYPTRNPSKAENMALVAVGGYGRGGLAQGSDIDLLFLLPYKQTPWGEQVVEYTLYMLWDMGLKVGHSTRNIDECIRLAREDMTIRTALLDARFLTGDKDLFRTLEIRFEEEIVKGTEPEFIQAKLAERDARHRKAGETRYLVEPNVKEGKGGQRDLHTLFWITKYFYRVKTKEELVKLGVLSRAELKLFNKAEDFLWAVRCHMHFATLKAEERLSFDIQPEIAQRLGYTAHPGQNYVERFMKHYFLVAKDVGDLTRIICAALEEQQAKHVPGFNRIFLTFSRRKRKLSDDGAFISENHRINIARPDIFRQDPVNMIRLFHLADRHGLEFHPEAMQSLTRSLKLINADLRENPEANRLFLEILTSPRNPELILRRMNESGVLGKFIPDFGKIVAMMQFNMYHHYTVDEHLLRCIAVLSEIEHGELKTEHPLSNHLITTIKRDRNLLYVTLLLHDIAKGRPEDHSIAGARIARRLCPRFGLTPSETETVEWLVREHLTMSMVAQSRDLNDRKTIIDFADTVQTMERLKLLLILTVCDIKAVGPGIWNGWKGQLLRTLFYETELVLTGGFSELSRAARDKQAREALAERLSDWPKEERDAYLALPYTNYFLTVSLDDQVRHAHFIRDADQQGRALVTMAKPHAFEAVTEITVLAPDHPRLLSVITGACAAAGGNIVDAQIFTTSNGRALDTILISREFDTDDDERRRAERVGKVIEDVLSGKAHLPDMLAKRTKPKKAARAFKVEPRVEINNTLSNKFTVIEVEGLDRPGLLSELTGLISDLSLDIASAHITTFGEKVIDSFYVTDLVGHKISNATRQGNIKRKLLALLGAENGARTNGRSPQAAA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Modifies, by uridylylation or deuridylylation the PII (glnB) regulatory protein (By similarity)(UniProt: Q8G312).

CATALYTIC ACTIVITY: UTP + [protein-PII] = diphosphate + uridylyl-[protein-PII](UniProt: Q8G312).

SIMILARITY: Belongs to the glnD family(UniProt: Q8G312).

MUTATION: glnD encodes for a uridylyl transferase which is the primary sensor of nitrogen. The glnD mutant via signature-tagged transposon mutagenesis is attenuated in THP1 macrophages and HeLa cells. It supports the hypothesis that the concentration of glutamine in host cells is critical for the intracellular survival of Brucella (Foulongne et al., 2000).
COG COG2844O, under O: Posttranslational modification, protein turnover, chaperones
References
Foulongne et al., 2000: Foulongne V, Bourg G, Cazevieille C, Michaux-Charachon S, O'Callaghan D. Identification of Brucella suis genes affecting intracellular survival in an in vitro human macrophage infection model by signature-tagged transposon mutagenesis. Infection and immunity. 2000; 68(3); 1297-1303. [PubMed: 10678941].