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pheA from Brucella suis 1330

Victor ID 1024
Gene Name pheA from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165694
NCBI Protein GI 23500952
Locus Tag BR0037
Protein Accession NP_697079.1
Other Database IDs UniProtKB-ID: Q8G3B3_BRUSU
UniRef100: UniRef100_D0B4A3
UniRef90: UniRef90_D0B4A3
UniRef50: UniRef50_B6JJE5
UniParc: UPI00000DD192
EMBL: AE014291
EMBL-CDS: AAN28994.1
RefSeq_NT: NC_004310.3
GenomeReviews: AE014291_GR
KEGG: bms:BR0037
TIGR: BR0037
HOGENOM: HBG693866
OMA: EDEAHNT
ProtClustDB: PRK11899
BioCyc: BSUI204722:BR_0037-MONOMER
Taxonomy ID 204722
Chromosome No I
Gene Starting Position 42209
Gene Ending Position 43072
Gene Strand (Orientation) -
Protein Name prephenate dehydratase
DNA Sequence 
>gi|56968325:42209-43072 Brucella suis 1330 chromosome I, complete sequence
ATTATTCGGCAGCCAGTAGCTGCGTACCGCGAATATCGCTTCCCTTGTAAACGCCCAGAATTCGCACTTC
CTTGGTGAAGAAGCGCAGTTCTTCCAGTGCAAGCTGCACCGAACGCTCTTCCGGGTGTCCCTCGATATCG
GCATAGAACTGCGTTGCGATGAAGCGTCCGCCGAGCTGATAGCTTTCGAGCTTCGTCATATTGACGCCAT
TGGTGGCGAAACCGCCCAGCGCCTTGTAAAGTGCGGCGGGCACGTTGCGCACCCGGAACACGAAGGTCGT
CACAATGCGCTCGTCGTTTTCAGGCCGCGCCGCCCACTGCTTGTTCTTGGAGAGGACCACGAAGCGGGTG
ACGTTGTTTTCGGAATCCTCGACATTTTCTTCCAGAATATCGAGGCCGTAGAGATCGGCGGCAAGACGTG
GCGCGAGTGCCGCCATCGAGCGATCCTTCACATCGGCGACGAGGCGCGCGGCCCCTGCCGTGTCACCGGC
AATCACACCCTTCCAGCCGTTCTGGCGGATGACGTTGCGGCACTGGCCGAGCGCGTGGATATGGCTGTGC
ACCGTCTTGATTTCCTCGCGCCGGACACCCGGAAGCACCATAAGCTGGAAATGGATCGGCAGGAAATATT
CGCCAACAATGTGCATGTCGGCCAGCGGCAGCAGATAATGAATATCGGCGACGCGCCCGGCCAGCGTGTT
CTCGATCGGGATCATCGCGAGGTCTGCGGCGCCGGTTTCAACCGCATTGAAGGCATCCTCAAAAGTCGGG
CACGGCAAAGGCTCCATATCGGGAAACATGTTGCGGCACGCCGTATCGGAGTTTGCGCCTGCTTCACCCT
GGAAGGAAATCCTGTTGGTTTTCA
Protein Sequence 
>gi|23500952|ref|NP_697079.1| prephenate dehydratase [Brucella suis 1330] MKTNRISFQGEAGANSDTACRNMFPDMEPLPCPTFEDAFNAVETGAADLAMIPIENTLAGRVADIHYLLPLADMHIVGEYFLPIHFQLMVLPGVRREEIKTVHSHIHALGQCRNVIRQNGWKGVIAGDTAGAARLVADVKDRSMAALAPRLAADLYGLDILEENVEDSENNVTRFVVLSKNKQWAARPENDERIVTTFVFRVRNVPAALYKALGGFATNGVNMTKLESYQLGGRFIATQFYADIEGHPEERSVQLALEELRFFTKEVRILGVYKGSDIRGTQLLAAE
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: The product of pheA gene is specifically dedicated to the biosynthesis of phenylalanine. The B. abortus pheA mutant with mini-Tn5 disruption displays nutritional defects in vitro. Experimental findings with the B abortus ilvD, trpB, and pheA mutants suggest that tryptophan and phenylalanine are available to the brucellae in their intracellular niche but that other amino acids (eg, leucine, isoleucine, or valine) are not. The pheA::miniTn5 mutant displayed attenuation in macrophages but not in mice (Alcantara et al., 2004).
COG COG0077E, under E: Amino acid transport and metabolism
References
Alcantara et al., 2004: Alcantara RB, Read RD, Valderas MW, Brown TD, Roop RM 2nd. Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model. Infection and immunity. 2004; 72(8); 4911-4917. [PubMed: 15271960].