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fliF from Brucella suis 1330

Victor ID 1022
Gene Name fliF from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165599
NCBI Protein GI 23500860
Locus Tag BRA1146
Protein Accession NP_700300.1
Other Database IDs UniProtKB-ID: FLIF_BRUSU
UniRef100: UniRef100_Q8FUS3
UniRef90: UniRef90_O52069
UniRef50: UniRef50_O52069
UniParc: UPI00000DDB72
EMBL: AE014292
EMBL-CDS: AAN34305.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA1146
NMPDR: fig|204722.1.peg.3209
TIGR: BRA1146
HOGENOM: HBG661951
OMA: RTIQSIS
ProtClustDB: PRK06007
BioCyc: BSUI204722:BR_A1146-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 1134151
Gene Ending Position 1135893
Gene Strand (Orientation) -
Protein Name flagellar MS-ring protein
DNA Sequence 
>gi|56968493:1134151-1135893 Brucella suis 1330 chromosome II, complete genome
CTCAGGCCGCCTTCAGCTCCGGCATGGCCGATGCCTTCGCCGGGTCGGCCTCACGGCCCGAAGCGGTTTC
GTGAATCCATTGCTTGAGAACGGCAGCAACACGCTCTTCATCCATTTCGATCATCTGTTCGAGCCTGAGC
TTGGCCGGCATACGCATACGCTGGCGCAGATCGCTGAGGCTCGTCTTCATCTGATCGGCATAGGCCGCAG
GACCGCCAATGACGGCCTGAACACCTTCGCCCACGCTTTCCGCGCCGCCGATAAAATTCGGCGTCGCGAC
CTCACCCGCCTCACGGATAGCGACTTCCGTACCCGCGGGCTTCACATTCTGGTCACGCAATAGCGGGCGC
AGGCCAAACCAGATCAGAAGGCCGACGGCGGCAAGAATGGCAAGCGCATTGGCATAGCTTCCACTCTGAC
GAAGAAGCGTATCGGTCCACGGTGCGGAAACAGGCTCCATATCCGCACCGGCAGGGTCAAGGAAATTGAC
CGCCGTGACGTTGATGACATCGCCGCGATTGGTATTGAGACCAGCGGCGGTGGCGACGAGATCGCGAATC
TTCGTAATCTGCTGGTCCACGAAATTGGCGGGTGGGGGTGTGGTGCCAGCGGTCTGCAACAGGCGCGCCT
GATCGATGACGACGGCGATTGAAAGCCGCTTGATGCTATAGCCGTCACTGACGGTTGAAACCGTCTTGCT
GTTCACTTCATAATTGGTCAGTTCCTCACGGCGGTCCGTCTTTTCAGTCGAGCTTTCGCCGTTGCGGTTC
TGGATTTGCTCCTGCGGAATGTTCTGCTCCACACCCGTCGCATTATCATTGCGGTTGTTGCGGGAATCGC
CGCTTTCGCGCACCACACGGACGGAACGCTCCACGCGCGATTCGGGATCATAGGTAGTTTCCTTGGTCTG
GCGGCGGTCGGTGTCGAGCGCGGCCTGAACGGAAGTCTGGAAATGACCCAGGCCAAGATAGGGCGCAAGC
GCCTTGCGGATGCTGTCGTCCACATGGCTCGCAACCTGCTGTTCAAGCGACGCGGTCATGAGAGCCGCAC
CATTGGCCCCTTCGCCAGCCGATGCCAGCAGATGGCCATTTGTATCGAGCACCGTGACGGAAGACGCATC
GAGCGAGGGAACGGCAGCGGCGACCAGCTGGCGGATGGACTGGGCCGATTCAGCGGAAAATCCGCCTTCG
GCACGAATAACGACCGAGGCAGACGGCTTCTGGTCGCCGCGGCGGAACGAGCCTTTTTCGGCCAGAACGA
TGTGAACGCGCGCAGCCTTCACGCCGCGAATGGCCTGAATGGTACGGGCAATTTCTCCTTCGAGCGCGCG
CACACGGGTAATCTCCTGCATAAAGGACGTAAGCCCCAGCGACCCCATATTGTCGAACAGCTCATAACCG
GCATTGTTCGAGGTCGGCAGGCCCTTTTCGGCCAGATACATGCGGGCGTTTTCGGCCTTGCCGATTGGAA
CGAGGATCGAGGATCCATCAGACTTCACGTCGAAGGGAATGCCAGCTTCACCGAGCGCAAGGCCCATGCG
GTTCACGTCATCGCGCGAAAGGCCGACATAGAGCGTCTCGTAGGATGGGCGACCCAGATAGATGCTCGTA
TAGAGGATCGCACCCATCAAAGCCGCGCCTACAAGGCCGAGCGCGATGAGCTTTCGCGCACCAAGCTTGC
CGAGCGTTCCCTTGAGCTGTTCGATCAATTGCTGGAAATTCTGCTGCATCCACACCACCGCCA
Protein Sequence 
>gi|23500860|ref|NP_700300.1| flagellar MS-ring protein [Brucella suis 1330] MAVVWMQQNFQQLIEQLKGTLGKLGARKLIALGLVGAALMGAILYTSIYLGRPSYETLYVGLSRDDVNRMGLALGEAGIPFDVKSDGSSILVPIGKAENARMYLAEKGLPTSNNAGYELFDNMGSLGLTSFMQEITRVRALEGEIARTIQAIRGVKAARVHIVLAEKGSFRRGDQKPSASVVIRAEGGFSAESAQSIRQLVAAAVPSLDASSVTVLDTNGHLLASAGEGANGAALMTASLEQQVASHVDDSIRKALAPYLGLGHFQTSVQAALDTDRRQTKETTYDPESRVERSVRVVRESGDSRNNRNDNATGVEQNIPQEQIQNRNGESSTEKTDRREELTNYEVNSKTVSTVSDGYSIKRLSIAVVIDQARLLQTAGTTPPPANFVDQQITKIRDLVATAAGLNTNRGDVINVTAVNFLDPAGADMEPVSAPWTDTLLRQSGSYANALAILAAVGLLIWFGLRPLLRDQNVKPAGTEVAIREAGEVATPNFIGGAESVGEGVQAVIGGPAAYADQMKTSLSDLRQRMRMPAKLRLEQMIEMDEERVAAVLKQWIHETASGREADPAKASAMPELKAA
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The M ring may be actively involved in energy transduction (By similarity)(UniProt: Q8FUS3).

SUBUNIT: The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The M ring is integral to the inner membrane of the cell and may be connected to the flagellar rod via the S ring. The S (supramembrane ring) lies just distal to the M ring. The L and P rings lie in the outer membrane and the periplasmic space, respectively (By similarity)(UniProt: Q8FUS3).

SUBCELLULAR LOCATION: Inner membrane; multi-pass membrane protein (By similarity)(UniProt: Q8FUS3).

SIMILARITY: Belongs to the fliF family(UniProt: Q8FUS3).

MUTATION: fliF is a gene potentially coding for the MS ring, a basal component of the flagellar system. Its mutant through signature- tagged mutagenesis is attenuated in vivo. It implicate a role for flagella in virulenc (Lestrate et al., 2003).
COG COG1766NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].