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eryB from Brucella suis 1330

Victor ID 1011
Gene Name eryB from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165308
NCBI Protein GI 23500593
Locus Tag BRA0865
Protein Accession NP_700033.1
Other Database IDs UniProtKB-ID: Q8FVH6_BRUSU
UniRef100: UniRef100_D0PGI4
UniRef90: UniRef90_B2SAH0
UniRef50: UniRef50_B5ZD29
UniParc: UPI00000DDAA3
EMBL: AE014292
EMBL-CDS: AAN34038.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0865
NMPDR: fig|204722.1.peg.2942
TIGR: BRA0865
HOGENOM: HBG720894
OMA: ILEEWAN
ProtClustDB: PRK13369
BioCyc: BSUI204722:BR_A0865-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 850235
Gene Ending Position 851743
Gene Strand (Orientation) +
Protein Name glycerol-3-phosphate dehydrogenase
DNA Sequence 
>gi|56968493:850235-851743 Brucella suis 1330 chromosome II, complete genome
AATGGCTGAACCGGAAACCTGCGACCTGTTTGTAATTGGCGGCGGCATCAACGGTGCGGGCGTGGCCCGC
GACGCGGCCGGGCGCGGCCTCAAGGTGGTGCTGGCAGAAAAGGACGATCTGGCGCAAGGCACATCATCGC
GCTCCGGCAAGCTGGTGCATGGCGGTTTGCGCTATCTCGAATATTATGAGTTCCGCCTTGTGCGCGAAGC
GCTGATCGAGCGCGAAGTGCTTTCGAATGCGGCACCCCATATCATCTGGCCGATGCGCTTCGTGCTGCCG
CACAGCCCGCAGGATCGCCCGGCCTGGCTGGTGCGGCTTGGCCTGTTTCTCTATGACCATCTGGGCGGGC
GCAAAAAACTTCCCGGCACGCGTACGCTCGATCTGAAGCGCGACCCGGAAGGCACGCCGATCCTCGACCA
GTACACCAAGGGTTTTGAATATTCCGATTGCTGGGTGGACGATGCGCGCCTCGTGGCGCTCAATGCGGTG
GGTGCCGCCGAAAAGGGCGCGACCATTCTCACCCGTACACCGGTCGTCTCCGCACGCCGCGAAAATGGCG
GCTGGATCGTGGAAACCAGAAACAGCGATACCGGCGAAACCCGCACCTTCCGCGCCCGCTGCATCGTCAA
TTGCGCCGGACCATGGGTCACGGACGTCATCCACAATGTCGCTGCCTCCACCTCGTCGCGCAATGTGCGC
CTCGTCAAGGGCAGCCACATCATCGTTCCGAAATTCTGGTCGGGCGCAAACGCCTATCTCGTTCAGAACC
ACGACAAGCGCGTGATCTTCATCAATCCATATGAAGGTGACAAGGCGCTGATCGGCACCACCGACATTGC
CTATGAAGGCCGGGCGGAAGACGTTGCGGCGGATGAGAAGGAAATCGACTATCTCATCACCGCGGTAAAC
CGCTATTTCAAGGAAAAGCTCCGGCGCGAAGACGTGCTGCACTCCTTCTCCGGCGTGCGCCCGCTGTTTG
ACGACGGCAAGGGCAATCCTTCCGCCGTCACCCGCGATTACGTGTTCGATCTGGACGAAACCGGCGGTGC
ACCGCTGCTCAACGTCTTTGGCGGCAAGATCACCACCTTCCGCGAACTGGCGGAGCGCGGGATGCATCGG
CTCAAGCACATTTTCCCGCAAATGGGCGGCGACTGGACCCACGACGCGCCGCTGCCCGGCGGCGAGATTG
CCAATGCCGATTATGAAACCTTCGCCAATACCTTACGCGACATCTATCCATGGATGCCGCGCACACTCGT
TCATCATTATGGACGGCTCTATGGTGCGCGCACAAAGGATGTGGTGGCTGGCGCGCAGAACCTCGAAGGG
CTTGGCCGTCACTTCGGCGGCGATTTCCATGAGGCGGAAGTGCGCTATCTGGTGGCCAGAGAATGGGCAA
AGACGGCAGAAGACATTCTCTATCGCCGCACCAAGCATTACCTGCATTTGACCGAAGCCGAACGCGCCGC
TTTCGTGGAATGGTTCGACAACGCCAATCTAGTTGCTTG
Protein Sequence 
>gi|23500593|ref|NP_700033.1| glycerol-3-phosphate dehydrogenase [Brucella suis 1330] MAEPETCDLFVIGGGINGAGVARDAAGRGLKVVLAEKDDLAQGTSSRSGKLVHGGLRYLEYYEFRLVREALIEREVLSNAAPHIIWPMRFVLPHSPQDRPAWLVRLGLFLYDHLGGRKKLPGTRTLDLKRDPEGTPILDQYTKGFEYSDCWVDDARLVALNAVGAAEKGATILTRTPVVSARRENGGWIVETRNSDTGETRTFRARCIVNCAGPWVTDVIHNVAASTSSRNVRLVKGSHIIVPKFWSGANAYLVQNHDKRVIFINPYEGDKALIGTTDIAYEGRAEDVAADEKEIDYLITAVNRYFKEKLRREDVLHSFSGVRPLFDDGKGNPSAVTRDYVFDLDETGGAPLLNVFGGKITTFRELAERGMHRLKHIFPQMGGDWTHDAPLPGGEIANADYETFANTLRDIYPWMPRTLVHHYGRLYGARTKDVVAGAQNLEGLGRHFGGDFHEAEVRYLVAREWAKTAEDILYRRTKHYLHLTEAERAAFVEWFDNANLVA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: EryB is an erythritol phosphate dehydrogenase. The vaccine strain B abortus B19 is the only known B abortus isolate whose growth is inhibited by erythritol. The B abortus B19 strain is an eryCD double mutant. The defect in B19 was complemented in trans by plasmids containing the complete ery region and by plasmids with Tn1725 insertions in eryA, eryB and eryD. Plasmids with Tn1725 insertions in eryC were the only ones that failed to complement the Ery phenotype of B19 (Sangari et al., 2000).

The B. suis eryB mutant by Tn5 transposon mutagenesis was attenuated in the human macrophage -like THP-1 cells. This mutant is sensitive to erythritol and mimics the erythritol sensitive response of the B19 strain (Sangari et al., 2000).
COG COG0578C, under C: Energy production and conversion
References
Sangari et al., 2000: Sangari FJ, Agüero J, García-Lobo JM. The genes for erythritol catabolism are organized as an inducible operon in Brucella abortus. Microbiology (Reading, England). 2000; 146 ( Pt 2); 487-495. [PubMed: 10708387].