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xseA from Brucella suis 1330

Victor ID 1007
Gene Name xseA from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165206
NCBI Protein GI 23500501
Locus Tag BRA0764
Protein Accession NP_699941.1
Other Database IDs UniProtKB-ID: EX7L_BRUSU
UniRef100: UniRef100_Q8FVR1
UniRef90: UniRef90_B2SAR1
UniRef50: UniRef50_B6IXD4
UniParc: UPI00000DDA53
EMBL: AE014292
EMBL-CDS: AAN33946.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0764
NMPDR: fig|204722.1.peg.2850
TIGR: BRA0764
HOGENOM: HBG634411
OMA: LVWPVKV
ProtClustDB: PRK00286
BioCyc: BSUI204722:BR_A0764-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 744985
Gene Ending Position 746520
Gene Strand (Orientation) -
Protein Name exodeoxyribonuclease VII large subunit
DNA Sequence 
>gi|56968493:744985-746520 Brucella suis 1330 chromosome II, complete genome
CTTACTGGCCTTTGGTCGGATCGGGGATTGTGAGTCCCGCGCGCGCGACAACCCCGACATCACCGTCGCG
GAACCGGACAGACAGCGCATCGCCTGGCAACACAGCCGCCGCCTGCTTGACGGGCTTGCCCTGCGCATCG
AATACAACAGCAAAGCCGCGTTCCAGCACGCTTTCATAAGAAAGCGTGCGCATCAACCGGTCGAGTTCTT
GACTGCGCCGCTTCACACGCTCGATCAGAAGCCGCACGGCCTGATCGCGGCGGCGGTCGAGCTGTTCGAG
GGTCGAGCCCGTCAGCCGTGTGCGGCGCAATATGGGTTCCGGCGAAAGCCGGTTGGCGCGATGGGTGAAA
GCCGTCCGGCGCTCGCGCAGAAAGGCTTCCAGCGCGCGCGGCAGGCGCTGGCCCAGCATCGTCACACCGC
GTTCCAGCTCCACAAGCCGCCGCTGTAAAAGCCGGGGCGACAATTGCCGGGCATGACCATCGAAATGGAC
GCGCTTTTTCTGCGTATTGACGAAAAGTGCGCGGGTAAGCCGCGAGGCCGCTTCATCGAACCGGCGGCGC
GGCAGGGCCAGCAACTGGTCGGCAGAGGGCATGGCGCGCGCGGCAGCACGATGCGCCTGTCGCTTCTGGT
CGAAAAAGCGCGACATGGCGGAAGAAAGCCGCGCCGACTGGCTGGCAAGTGAGGCCTGAAGATCAGCCTT
CACCGGCACCGCCATTTCCGCAGCACCGGTGGGGGTCGGCGCGCGCATGTCGGCGGCAAGATCTATCAGC
GTCCAGTCGGTTTCATGCCCGACCGCCGAGATAACGGGAATATGGGAAGCTGCGACCGCCCGCACGACGA
TTTCATCGTTAAAGCCCCAGAGATCTTCCAGACTGCCGCCGCCGCGCGCCACGATCAGCACATCGGGGCG
CGGAATGGGGCCGTCATCCGGCAGGGTGTTGAAGCCGTTCACCGCCGTTGCCACTTCAGGCCCGCAGGTA
TCGCCCTGCACGCGCACCGGCCAGACGATCACGCGCAGCGGATAACGATCGGAAATGCGATGGATGATAT
CGCGGATGACCGCGCCGGTGGGAGATGTCACCACGCCGATGACGCGCGGCATGAAGGGCAGAAGCTGTTT
CAGGGCAGGATCGAACAGGCCTTCTGCCGCCAGGCGCTGCTTGCGCTCCTCCAGAAGCGCCATCAGCGCG
CCCGCGCCGGCGGGTTCCATCTGCTCGATGACGATCTGATATTTGGATGAACCGGGATAGGTGGTGAGCT
TGCCGGTGGCGATCACCTCCATGCCCTCTTCGGGGCGGAAGCGAAGGCGGCTCATCGAGCCGCGCCAGAT
CACGGCTTCAAGCCGGGCACGGTCATCCTTCAGCGCAAAATAGGCATGGCCGGAAGAATGCGGGCCGCGA
TAGCCGGAAATCTCGCCGCGCACACGCACATGGCCGAACGTGTCCTCAACCGTGCGCTTCAAAGCGCCGG
AAATCTCGGACACGCTATACTCGGCCACATTCGACGATGCGCCGGGAAAACTCGAATCGGAGGCCA
Protein Sequence 
>gi|23500501|ref|NP_699941.1| exodeoxyribonuclease VII large subunit [Brucella suis 1330] MASDSSFPGASSNVAEYSVSEISGALKRTVEDTFGHVRVRGEISGYRGPHSSGHAYFALKDDRARLEAVIWRGSMSRLRFRPEEGMEVIATGKLTTYPGSSKYQIVIEQMEPAGAGALMALLEERKQRLAAEGLFDPALKQLLPFMPRVIGVVTSPTGAVIRDIIHRISDRYPLRVIVWPVRVQGDTCGPEVATAVNGFNTLPDDGPIPRPDVLIVARGGGSLEDLWGFNDEIVVRAVAASHIPVISAVGHETDWTLIDLAADMRAPTPTGAAEMAVPVKADLQASLASQSARLSSAMSRFFDQKRQAHRAAARAMPSADQLLALPRRRFDEAASRLTRALFVNTQKKRVHFDGHARQLSPRLLQRRLVELERGVTMLGQRLPRALEAFLRERRTAFTHRANRLSPEPILRRTRLTGSTLEQLDRRRDQAVRLLIERVKRRSQELDRLMRTLSYESVLERGFAVVFDAQGKPVKQAAAVLPGDALSVRFRDGDVGVVARAGLTIPDPTKGQ
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)(UniProt: Q8FVR1).

CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates(UniProt: Q8FVR1).

SUBUNIT: Heterooligomer composed of large and small subunits (By similarity)(UniProt: Q8FVR1).

SUBCELLULAR LOCATION: Cytoplasm (By similarity)(UniProt: Q8FVR1).

SIMILARITY: Belongs to the xseA family(UniProt: Q8FVR1).

MUTATION: xseA codes for an exodeoxyribonuclease. B. melitensis xseA mutant via signature-tagged mutagenesis is attenuated in vivo in mice (Lestrate et al., 2003).
COG COG1570L, under L: Replication, recombination and repair
References
Lestrate et al., 2003: Lestrate P, Dricot A, Delrue RM, Lambert C, Martinelli V, De Bolle X, Letesson JJ, Tibor A. Attenuated signature-tagged mutagenesis mutants of Brucella melitensis identified during the acute phase of infection in mice. Infection and immunity. 2003; 71(12); 7053-7060. [PubMed: 14638795].