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gcvP from Brucella suis 1330

Victor ID 1005
Gene Name gcvP from Brucella suis 1330
Sequence Strain (Species/Organism) Brucella suis 1330
NCBI Gene ID 1165167
NCBI Protein GI 23500462
Locus Tag BRA0725
Protein Accession NP_699902.1
Other Database IDs UniProtKB-ID: GCSP_BRUSU
UniRef100: UniRef100_Q8FVU9
UniRef90: UniRef90_B2SAU5
UniRef50: UniRef50_Q28L73
UniParc: UPI00000DDA32
EMBL: AE014292
EMBL-CDS: AAN33907.1
RefSeq_NT: NC_004311.2
GenomeReviews: AE014292_GR
KEGG: bms:BRA0725
NMPDR: fig|204722.1.peg.2811
TIGR: BRA0725
HOGENOM: HBG286723
OMA: PETIMIE
ProtClustDB: PRK05367
BioCyc: BSUI204722:BR_A0725-MONOMER
Taxonomy ID 204722
Chromosome No II
Gene Starting Position 708890
Gene Ending Position 711688
Gene Strand (Orientation) -
Protein Name glycine dehydrogenase
DNA Sequence 
>gi|56968493:708890-711688 Brucella suis 1330 chromosome II, complete genome
GTCAGCCATAGGCTGCGACAGGCGGGCAGGAGCAGATGAGGTTCCGGTCGCCGCCGACATTATCCACGCG
GCTGACCGGCGGCCAATATTTTGCCGTCGGATCGAAAGCACCGCCGGGGAATACGGCTTCCTCACGGGTA
TAGGGATGCTTCCATTCCGTTGCCAGCGTATCGCTCGCCGTATGCGGCGCATTGGCAAGCGGATTGTCAT
CCGCAGGCCAGACGCCATCGGCAACCTTCTTCGCCTCGCCTGCAATCGCGATCATCGCATCGCAAAGACG
GTCGATCTCCAGCTTGGGCTCGGACTCGGTCGGCTCGATCATCAGCGTTCCGGCAACCGGCCATGACATG
GTCGGCGCATGGAAACCATAGTCGATCAGGCGCTTGGCCACGTCTTCCACGGTAATGCCCGCACTGTCCT
TCAATACGCGCGTATCCACGATGCATTCATGCGCCACGCGGTCATGCGCGCCGGTATAAAGGATCGGGTA
AACACCCTTCAGACGATGCGCAATATAATTGGCATTGAGGATTGCAGCTTCCGTCGCCTTCTTCAAACCG
GCCCCGCCCATCATGCGGATATACATCCACGTAATGACCAGAATGGATGCGCTGCCGAACTGCGCTGCGG
CAACAGCGTGTTCGGAACCGGCTTCCACATGGCCCGGCAGATAAGGCACCAGATGTTTCGCCACGCCAAT
CGGGCCAACACCCGGACCACCGCCGCCATGCGGGATGCAGAAGGTCTTGTGCAGATTCATGTGGCAGACG
TCCGCGCCGATATCGGCAGGCCGCGCCAGACCGACAAGCGCATTGAGGTTCGCGCCGTCGAAATAGACCT
GGCCGCCATTGTCATGCACAATCTCGCAGAAGGCTTTGATGCCTTCCTCGAACACGCCATAGGTGGACGG
ATAGGTAATCATGAAGGCGGCGAGATTATCGCGATGCTTTTCCGCCTTGGCCTTGAGATCATCAATATCG
ATGTCGCCATCCGGGCGGCAATTGACGACGACGACGCTCATGCCCGCCATGGAGGCGCTGGCCGGATTGG
TGCCATGCGCCGAGGACGGGATAAGGCAGATGTTGCGATGGCCCTGCCCCCACGCCTGATGATAGTGGCG
GATGGCCATAAGGCCGGCATATTCACCCTGACTACCGGCATTTGGCTGCAATGAAACGCCCGCAAAACCG
GTGATTTCGCAAAGCCATGCTTCCAGATCGGAAGTCATTTTCGCATAACCCTGCACCTGCTCGGCAGGCG
CAAAAGGATGCAGGTTTGCAACCGTATTCCAGCTCACCGGCATCATTTCTGCCGCCGCATTGAGCTTCAT
CGTGCAGGAACCAAGCGGGATCATCGCGCGGTCGAGCGCCAGATCCTTGTCGGCCAGACGACGCAGGAAG
CGCATCATCTCGGTTTCGGAACGATGTGAATGGAATACTTCCTGCGTGAGGAAACCTTCCCCGCGTTCCT
TGCCCGGAACAAGAACTGTGTCGCCGCCAACCGGCTTCGCACCGAAGAGCGATGCCAGGGCCGTCAGATC
CTCTTCCGTCGAGGTTTCGTCGAAAGTGACGCCGACCGTATCCGCATCGATGATGCGGATCAGGCGGCCG
CCCTTGTCGGCTTCGGCTGCGATTGCCGCGGCTTTGCCCGGAACCTTGGCCGTTACCGTATCGAACAGGC
TTTCGCCCGCAATTTCAACACCGGCAGCCTTGAGCGCGGCAGCAAAACGGGCGGCCAGAGCGGCCACGCG
CGTTGCAATCGCCTGCAAGCCAGCCGGGCCATGCCAGATGGCGAAAGCTGCGGCCATGTTGGCCAGAAGC
GCCTGCGCGGTGCAGATATTGGAGGTCGCCTTGTCGCGGCGGATGTGCTGCTCGCGGGTCTGGAGCGCCA
GACGATAGGCCGCGCGGCCATGCGCATCGACCGACTGGCCGACGATGCGGCCCGGAATAATGCGAGTGAG
CGCCTCGGACACTGCAAGATAAGCCGCGTGCGGGCCGCCAAAGCCCATCGGCACGCCATAGCGCTGCATG
GAGCCGACGGCCATGTCCGCGCCCCACCTGGCAGGCGCTTCCATGATGGTGAGCGCCAGCGGATCGGCAA
CGGCGATAACCAGCGCACCCTTGGCCTTGGCATCGGCAATGACCTTGGCAAAATCGCCATAGACGCCGCG
CGTATCCGGCCATGGAACCACGATTGCGGCGGTGTTGTCGTCAACATCGCTGCCGGTGGCGATCTCCCAG
CCGAGCGGTTCAGCGCGGGTGTTCACCACATCGACCGTCTGCGGATGCAGTTCGCCAGCAAGCAGAATGC
GGCTGCGCTTGTCGCGATGATGGCGGCAGGCAACGCCGATGGCTTCGGCAACGGCAGTCGCCTCGTCGAG
CAGCGAGGCACAGGCAACCGGCAGGCCGGTCAGTTCGGCAACCAGTGTCTGGAAGTGGAACAGAAGCTCA
AGGCGGCCCTGGCTGATTTCCGACTGGTAGGGCGTATAAGCCGTGTACCAGGCCGGGTTTTCAAACAGGT
TGCGCTGGATGACCGGTGGCGTGTGAACACCGTGATAGCCCGCGCCGATGAAGCTCTTCTTCACCACGTT
GCGGCCCATGATCGTGCCCAGTTCCGCAAGTGCGTCCGCTTCGCTGAGCGCCGCTGGCAGGTTCAGCGCG
CGGTTGAGGCGAATGGAGGCCGGAACCGCCTGCGTTATGAGGGTTTCCATGGAAGGAAGGCCGAGCGCTG
CCAGCATGGCGCGCTCGTCTTCATGTCTCGGCCCGATATGGCGGGCCACAAAGGGAAGAAATTCGGTCA
Protein Sequence 
>gi|23500462|ref|NP_699902.1| glycine dehydrogenase [Brucella suis 1330] MTEFLPFVARHIGPRHEDERAMLAALGLPSMETLITQAVPASIRLNRALNLPAALSEADALAELGTIMGRNVVKKSFIGAGYHGVHTPPVIQRNLFENPAWYTAYTPYQSEISQGRLELLFHFQTLVAELTGLPVACASLLDEATAVAEAIGVACRHHRDKRSRILLAGELHPQTVDVVNTRAEPLGWEIATGSDVDDNTAAIVVPWPDTRGVYGDFAKVIADAKAKGALVIAVADPLALTIMEAPARWGADMAVGSMQRYGVPMGFGGPHAAYLAVSEALTRIIPGRIVGQSVDAHGRAAYRLALQTREQHIRRDKATSNICTAQALLANMAAAFAIWHGPAGLQAIATRVAALAARFAAALKAAGVEIAGESLFDTVTAKVPGKAAAIAAEADKGGRLIRIIDADTVGVTFDETSTEEDLTALASLFGAKPVGGDTVLVPGKERGEGFLTQEVFHSHRSETEMMRFLRRLADKDLALDRAMIPLGSCTMKLNAAAEMMPVSWNTVANLHPFAPAEQVQGYAKMTSDLEAWLCEITGFAGVSLQPNAGSQGEYAGLMAIRHYHQAWGQGHRNICLIPSSAHGTNPASASMAGMSVVVVNCRPDGDIDIDDLKAKAEKHRDNLAAFMITYPSTYGVFEEGIKAFCEIVHDNGGQVYFDGANLNALVGLARPADIGADVCHMNLHKTFCIPHGGGGPGVGPIGVAKHLVPYLPGHVEAGSEHAVAAAQFGSASILVITWMYIRMMGGAGLKKATEAAILNANYIAHRLKGVYPILYTGAHDRVAHECIVDTRVLKDSAGITVEDVAKRLIDYGFHAPTMSWPVAGTLMIEPTESEPKLEIDRLCDAMIAIAGEAKKVADGVWPADDNPLANAPHTASDTLATEWKHPYTREEAVFPGGAFDPTAKYWPPVSRVDNVGGDRNLICSCPPVAAYG
Molecule Role Virulence factor
Molecule Role Annotation FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity)(UniProt: Q8FVU9).

CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO(2)(UniProt: Q8FVU9).

COFACTOR: Pyridoxal phosphate (By similarity)(UniProt: Q8FVU9).

SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H (By similarity)(UniProt: Q8FVU9).

SIMILARITY: Belongs to the gcvP family(UniProt: Q8FVU9).

MUTATION: gcvP encodes for glycine dehydrogenase and is required for persistent infection in mouse model (Ficht, 2003).
COG COG1003E, under E: Amino acid transport and metabolism
References
Ficht, 2003: Ficht TA. Intracellular survival of Brucella: defining the link with persistence. Veterinary microbiology. 2003; 92(3); 213-223. [PubMed: 12523983].