Protegen ID	Gene Name	Sequence Strain (Species/Organism)	NCBI Gene ID	NCBI Nucleotide GI	NCBI Protein GI	Locus Tag	Genbank Accession	Protein Accession	Protein Name	Protein Annotation	Molecule Role	Molecule Role Annotation	COG	PMID
5033	Ac-p74	Autographa californica nucleopolyhedrovirus	1403971		9627881	ACNVgp139	L22858	NP_054168	occlusion-derived virus envelope protein		Virulence factor	Ac228z, in which portions of adjacent carboxy-termini from peptides p74 and p10 were deleted, failed to kill larvae, whereas virus with deletions in p10 alone were as infectious to larvae as wild-type virus.   [Ref7437:Kuzio et al., 1989]		2688302
5034	OpmnVgp129	Orgyia pseudotsugata MNPV	912086		9630067	OpmnVgp129	U75930	NP_046285	polyhedral envelope protein		Virulence factor	the absence of the polyhedral envelope and the efficient release of occluded virions are responsible for the increased virulence of polyhedral envelope negative mutants.;  [Ref7438:Zuidema et al., 1989]		2683364
5080	pe38	Bombyx mori NPV	1488760		9630952	Bmnpvgp136	L33180	NP_047549	PE38		Virulence factor	a knockout virus, Delta pe38-E9/E9, in which the pe38 open reading frame was replaced with that of the green fluorescent protein. We compared mutant and wild-type (WT) viral replication in insect cell culture and virulence in Heliothis virescens larvae. Compared to WT, Delta pe38-E9/E9 budded virus (BV) production was delayed by at least 3 h, and BV yields were reduced over 99%. Similarly, Delta pe38-E9/E9 DNA synthesis levels were greatly reduced relative to those of WT, but onset of DNA replication was the same for both viruses. In bioassays, nearly sevenfold more Delta pe38-E9/E9 virus than WT virus was required to achieve an LD(50) when administered orally, but not hemocoelically. [Ref7482:Milks et al., 2003]		12781710
5094	Orf_56	Bombyx mori NPV	1488687		9630875	Bmnpvgp059	JQ991009	NP_047472	AcMNPV orf68		Virulence factor	 Bioassay with Trichoplusia ni demonstrated that deletion of ac68 did not affect AcMNPV infectivity, but extended LT(50) to a longer value. Taken together, our results indicated that the deletion did not affect viral propagation both in vitro and in vivo, but deletion of the gene may affect the virulence in T. ni larvae.  [Ref7494:Li et al., 2008]		18483845