Protegen ID	Gene Name	Sequence Strain (Species/Organism)	NCBI Gene ID	NCBI Nucleotide GI	NCBI Protein GI	Locus Tag	Genbank Accession	Protein Accession	Protein Name	Protein Annotation	Molecule Role	Molecule Role Annotation	COG	PMID
4829	exgmp	Leishmania mexicana MNYC/BZ/62/M379			12584592				GDP-mannose pyrophosphorylase		Virulence factor	MUTATION: GDPMP (exgmp) mutant is unable to infect macrophages or mice [Ref7256:Garami and Ilg, 2001].; 		11447107
4830	pmm	Leishmania mexicana M379			15387672				phosphomannomutase		Virulence factor	MUTATION: PMM mutant is attenuated in mice and murine macrophages [Ref7257:Garami et al., 2001].; 		11689705
4831	Cht1	Leishmania mexicana M379			48375060				chitinase		Virulence factor	MUTATION: Overexpression of Cht1 in L. mexicana increased survival within sandfly vector, and more virulent infections in mice [Ref7258:Rogers et al., 2008].; 		18284631
5166	PMI	Leishmania mexicana MHOM/GT/2001/U1103	13453593		401427037	LMXM_31_1580	FR799584	XP_003878002			Virulence factor	The Delta lmexpmi mutant is attenuated in infections of macrophages in vitro and of mice.  [Ref7565:Garami and Ilg, 2001]		11084042
5167	LMCPB				1730100				Cysteine proteinase B		Virulence factor	deletion of the entire multicopy cysteine protease B (CPB) gene array in L. mexicana is associated with decreased parasite virulence. [Ref7566:Buxbaum et al., 2003]		14500670
5169	ICP	Leishmania mexicana MHOM/GT/2001/U1103	13448953		401423014	LMXM_24_1770	FR799577	XP_003875994			Virulence factor	Null mutants grew normally in vitro, were as infective to macrophages in vitro as wild-type parasites, but had reduced infectivity to mice. Mutants re-expressing ICP from a single gene gave partial restoration of virulence in vivo, whereas mutants overexpressing ICP secreted the inhibitor and showed markedly reduced virulence in mice.[Ref7568:Besteiro et al., 2004]; 		15554964
5217	 LmexCht1	Leishmania mexicana MHOM/GT/2001/U1103	13450317		401418548	LMXM_16_0790	FR799569	XP_003873765			Virulence factor	the LmexCht1 transfectants survived significantly better in human macrophages and also produced significantly larger lesions in mice than control parasites. ; [Ref7611:Joshi et al., 2005]		15561707