Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 4771 ace Enterococcus faecalis OG1RF 10863204 10863205 AAG23931.1 collagen adhesin precursor Virulence factor MUTATION: an ace deletion mutant is significantly attenuated in a mixed infection rat endocarditis model [Ref7231:Singh et al., 2010].; 20072611 4772 EF3314 Enterococcus faecalis V583 1202157 29377755 EF3314 AE016830 NP_816909 cell wall surface anchor family protein Virulence factor MUTATION: EF3314 deletion mutant is attenuated in attachment to HeLa cells, survival within macrophages and in a C. elegans killing model [Ref7232:Creti et al., 2009].; 19856273 4773 ers Enterococcus faecalis 72528353 72528354 AAZ73009.1 transcriptional regulator Virulence factor MUTATION: ers mutant is attenuated in mouse peritonitis model [Ref7233:Riboulet-Bisson et al., 2008].; 18426870 4774 srtC Enterococcus faecalis V583 1199996 29375670 EF1094 AE016830 NP_814824 sortase family protein Virulence factor MUTATION: bps (srtC) mutant is attenuated in mice [Ref7234:Kemp et al., 2007].; 17785477 4775 perR Enterococcus faecalis 67043736 PerR Virulence factor MUTATION: perR mutant is attenuated in mice [Ref7235:Verneuil et al., 2005].; 16339944 4776 fsrA Enterococcus faecium 226938234 226938235 ACO94083.1 FsrA Virulence factor MUTATION: fsrA mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].; 12228293 4777 fsrB Enterococcus faecalis 48428174 Protein FsrB Virulence factor MUTATION: fsrB mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].; 12228293 4778 gelE Enterococcus faecalis 148310 148311 AAA24778.1 gelatinase Virulence factor MUTATION: gelE mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].; 12228293 4779 sprE Enterococcus faecalis 43337 43338 CAA78168.1 Staphylococcal serine proteinase homologue Virulence factor MUTATION: sprE mutant is attenuated for killing C. elegans [Ref7236:Sifri et al., 2002].; 12228293 4780 scrB-1 Enterococcus faecalis V583 1200501 29376163 EF1603 AE016830 NP_815317 sucrose-6-phosphate dehydrogenase Virulence factor MUTATION: scrB mutant is avirulent in C. elegans and attenuated in mice [Ref7237:Garsin et al., 2001].; MUTATION: scrB-1 mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].; 11535834, 17307944 4781 purL Enterococcus faecalis V583 1200671 29376329 EF1782 AE016830 NP_815483 phosphoribosylformylglycinamidine synthase II Virulence factor MUTATION: purL mutant is attenuated in mice [Ref7238:Singh et al., 1998].; 9780263 4782 cylR1 Enterococcus faecalis 18139788 18139789 AAL60139.1 CylR1 Virulence factor MUTATION: nonhemolytic pAD1 plasmid (cylR1) insertions mutants were attenuated compared to strains with normal hemolytic phenotype in mice [Ref7239:Ike et al., 1984].; 6086531 4783 efaA Enterococcus faecalis 306753329 endocarditis specific antigen Virulence factor MUTATION: efaA mutant is attenuated in mouse peritonitis model [Ref7240:Singh et al., 1998b].; 9753005 4784 esp Enterococcus faecalis 111380585 surface protein Esp Virulence factor MUTATION: esp mutant is attenuated in murine model of urinary tract infection [Ref7241:Shankar et al., 2001].; 11401975 4785 asa1 Enterococcus faecalis V583 1202219 29377844 EFA0047 AE016833 NP_816972 aggregation substance Asa1 Virulence factor MUTATION: asa1 deletion mutant has reduced adherence to macrophages, and an AS negative strain had decreased survival in macrophages compared to a AS positive strain [Ref7242:Süssmuth et al., 2000].; 10948103 4786 glf Enterococcus faecalis V583 1201351 29376979 EF2487 AE016830 NP_816133 UDP-galactopyranose mutase Virulence factor MUTATION: cpsI mutant is rapidly cleared from murine cutaneous infection sites compared to the wild type [Ref7243:Hancock and Gilmore, 2002].; 11830672 4787 bopD Enterococcus faecalis V583 1199842 29375537 EF0954 AE016830 NP_814691 LacI family sugar-binding transcriptional regulator Virulence factor MUTATION: bopD mutant has delayed colonization in murine intestinal tract [Ref7244:Creti et al., 2006].; 16834772 4788 srtA Enterococcus faecalis V583 1201902 29377514 EF3056 AE016830 NP_816668 sortase family protein Virulence factor MUTATION: srtA mutant is attenuated in murine urinary tract infection model [Ref7245:Guiton et al., 2010].; 20696830 4789 prgB Enterococcus faecalis 3267210 58616135 pCF10_16 AY855841 YP_195774 PrgB Virulence factor MUTATION: prgB mutant is attenuated in rabbit model of endocarditis [Ref7246:Chuang et al., 2009].; 18955479 4790 EF0382 Enterococcus faecalis V583 1199301 29375019 EF0382 AE016830 NP_814172 hypothetical protein Virulence factor MUTATION: EF0382 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4791 EF1302 Enterococcus faecalis V583 1200199 29375870 EF1302 AE016830 NP_815024 transcriptional regulator, putative Virulence factor MUTATION: EF1302 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4792 psr Enterococcus faecalis V583 1200469 29376132 EF1569 AE016830 NP_815286 transcriptional regulator, PSR protein Virulence factor MUTATION: psr mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4793 scrR-1 Enterococcus faecalis V583 1200502 29376164 EF1604 AE016830 NP_815318 sucrose operon repressor ScrR Virulence factor MUTATION: scrR-1 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4794 agrBfs Enterococcus faecalis V583 1200706 29376364 EF1821 AE016830 NP_815518 agrBfs protein Virulence factor MUTATION: fsrB (agrBfs) mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].; 17307944 4795 brnQ Enterococcus faecalis V583 1199135 29374885 EF0243 AE016830 NP_814038 branched-chain amino acid transport system II carrier protein Virulence factor MUTATION: brnQ mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4796 EF1513 Enterococcus faecalis V583 1200416 29376080 EF1513 AE016830 NP_815234 pheromone binding protein Virulence factor MUTATION: EF1513 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4797 EF2598 Enterococcus faecalis V583 1201458 29377084 EF2598 AE016830 NP_816238 PTS system, beta-glucoside-specific IIABC component Virulence factor MUTATION: EF2598 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4798 recQ-1 Enterococcus faecalis V583 1200445 29376108 EF1545 AE016830 NP_815262 ATP-dependent DNA helicase RecQ Virulence factor MUTATION: recQ-1 mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].; 17307944 4799 phrB Enterococcus faecalis V583 1200497 29376159 EF1598 AE016830 NP_815313 deoxyribodipyrimidine photolyase Virulence factor MUTATION: phrB mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].; 17307944 4800 phrB 4801 EF2591 Enterococcus faecalis V583 1201452 29377078 EF2591 AE016830 NP_816232 glyoxalase family protein Virulence factor MUTATION: EF2591 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4802 EF0737 Enterococcus faecalis V583 1199634 29375331 EF0737 AE016830 NP_814485 amidase Virulence factor MUTATION: EF0737 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4803 scrB-1 4804 EF1623 Enterococcus faecalis V583 1200521 29376182 EF1623 AE016830 NP_815336 microcompartment protein Virulence factor MUTATION: EF1623 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4805 thyA Enterococcus faecalis V583 1200476 29376139 EF1576 AE016830 NP_815293 thymidylate synthase Virulence factor MUTATION: thyA mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4806 map Enterococcus faecalis V583 1201076 29376708 EF2200 AE016830 NP_815862 methionine aminopeptidase Virulence factor MUTATION: map mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4807 EF0376 Enterococcus faecalis V583 1199295 29375014 EF0376 AE016830 NP_814167 hypothetical protein Virulence factor MUTATION: EF0376 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4808 EF0861 Enterococcus faecalis V583 1199754 29375449 EF0861 AE016830 NP_814603 acetyltransferase Virulence factor MUTATION: EF0861 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4809 EF1542 Enterococcus faecalis V583 1200442 29376105 EF1542 AE016830 NP_815259 hypothetical protein Virulence factor MUTATION: EF1542 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4810 EF1590 Enterococcus faecalis V583 1200489 29376151 EF1590 AE016830 NP_815305 protease synthase and sporulation negative regulatory protein pai 1, putative Virulence factor MUTATION: EF1590 mutant is attenuated in killing C. elegans and is attenuated in mice [Ref7247:Maadani et al., 2007].; 17307944 4811 EF1792 Enterococcus faecalis V583 1200680 29376338 EF1792 AE016830 NP_815492 hypothetical protein Virulence factor MUTATION: EF1792 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4812 EF2675 Enterococcus faecalis V583 1201532 29377157 EF2675 AE016830 NP_816311 competence protein, putative Virulence factor MUTATION: EF2675 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4813 EF2957 Enterococcus faecalis V583 1201809 29377421 EF2957 HC905410 NP_816575 hexapeptide repeat-containing acetyltransferase Virulence factor MUTATION: EF2957 mutant is attenuated in killing C. elegans [Ref7247:Maadani et al., 2007].; 17307944 4814 acm Enterococcus faecium 29134931 collagen adhesin precursor Virulence factor MUTATION: acm deletion mutant is attenuated in rat endocarditis model [Ref7248:Nallapareddy et al., 2008].; 18591236