Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 4907 gE Equid herpesvirus 1 330789 glycoprotein E Virulence factor MUTATION: A glycoprotein E mutant is attenuated in mice and hamsters [Ref1606:Patel and Heldens, 2005]. 15993786 4908 gI Equid herpesvirus 1 330788 glycoprotein I Virulence factor MUTATION: A glycoprotein I mutant is attenuated in mice and hamsters [Ref1606:Patel and Heldens, 2005]. 15993786 4962 TK Equid herpesvirus 1 Ab4 59214 thymidine kinase Virulence factor MUTATION: A thymidine kinase-deficient mutant (PR1) is attenuated in mice and foals [Ref7380:Slater et al., 1993]. 8388018 5072 ORF71 17221115 17221116 AAK61485.1 glycoprotein gp2 Virulence factor Irrespective of the reduced pathogenicity of the gene 71 mutant, infected mice were protected against a challenge with wild-type EHV-1. These findings highlight the potential of ED71 as a vaccine candidate. [Ref7474:Marshall et al., 1997] 9143298 5073 gC 378556085 378556086 AFC17871.1 glycoprotein C Virulence factor Infection of mice with L11(delta)gC did not cause EHV-1-related disease, whereas mice infected with either RacL11 or R-L11(delta)gC exhibited massive bodyweight losses, high virus titers in the lungs, and viremia. [Ref7475:Osterrieder, 1999] 10082388 5074 EUS8 119926891 119926892 BAF43294.1 glycoprotein E Virulence factor Colostrum-deprived Thoroughbred foals inoculated intranasally (i.n.) or intramuscularly (i.m.) with DeltagE did not exhibit any clinical signs of respiratory disease except for a mild nasal discharge in 1 i.n. inoculated foal on Days 1 and 3 post-infection. In contrast, the intranasal inoculation of foals with the revertant of DeltagE resulted in biphasic pyrexia, mucopurulent nasal discharge and swelling of submandibular lymph nodes. [Ref7476:TSUJIMURA et al., 2009] 19959893