Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 4464 PEX2 Trypanosoma brucei TREU927 3656173 72386807 Tb927.3.2340 CP000066 XP_843828 Virulence factor MUTATION: PEX2 RNA silenced mutant of the bloodstream form rapidly dies [Ref7002:Guerra-Giraldez et al., 2002]. 12077356 5201 VGS Trypanosoma brucei brucei strain 927/4 GUTat10.1 3655979 72386443 Tb927.3.340 CP000066 XP_843646 Virulence factor Mutant parasites exhibited markedly reduced infectivity thus demonstrating the importance of specific glycosylation patterns in parasite virulence.; [Ref7599:Castillo-Acosta et al., 2013] 23926900 5223 ORC1 70834184 origin recognition complex subunit 1 (ORC1), putative Virulence factor Depletion of TbOrc1 resulted in derepression of telomere-linked silent VSGs in both BF and PF, and increased VSG switching particularly through the in situ transcriptional switching mechanism. [Ref7619:Benmerzouga et al., 2013]; 23216794