Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 3938 yopP from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239114 10955541 pYVe227_p05 NP_052382.1 Yop effector YopP Virulence factor MUTATION: yopP mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3939 lcrV from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239123 10955551 pYVe227_p15 NP_052392.1 LcrV Virulence factor MUTATION: lcrV mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3940 yscR from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239136 10955564 pYVe227_p28 NP_052405.1 type III secretion system protein Virulence factor MUTATION: yscR mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3941 yscU from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239139 10955567 pYVe227_p31 NP_052408.1 YscU Virulence factor MUTATION: yscU mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3942 virG from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239140 10955568 pYVe227_p32 NP_052409.1 lipoprotein VirG (YscW) Virulence factor MUTATION: virG mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3943 virF from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239141 10955569 pYVe227_p33 NP_052410.1 transcriptional activator VirF Virulence factor MUTATION: virF mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3944 yscC from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239144 10955572 pYVe227_p36 NP_052413.1 secretin YscC Virulence factor MUTATION: yscC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3945 yscL from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239153 10955581 pYVe227_p45 NP_052422.1 type III secretion system protein Virulence factor MUTATION: yscL mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3946 sycH from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239156 10955584 pYVe227_p48 NP_052425.1 YopH chaperone SycH Virulence factor MUTATION: sycH mutant is attenuated in mice [Ref6845:Di et al., 2003]. 12654794 3947 yadA from Yersinia enterocolitica W22703 Yersinia enterocolitica W22703 1239174 10955604 pYVe227_p56 NP_052433.1 adhesin YadA Virulence factor MUTATION: yadA mutant is attenuated in mice [Ref6845:Di et al., 2003]. 12654794 3972 sycH from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239183 28372990 pYVa12790_p47 NP_783700.1 SycH Virulence factor MUTATION: sycH mutant is attenuated in mice [Ref6845:Di et al., 2003]. 12654794 3973 lcrV from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239194 28373003 pYVa12790_p12 NP_783665.1 LcrV Virulence factor MUTATION: lcrV mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3974 yscU from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239200 28373013 pYVa12790_p29 NP_783682.1 YscU Virulence factor MUTATION: yscU mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3975 yscC from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239201 28373014 pYVa12790_p34 NP_783687.1 hypothetical protein Virulence factor MUTATION: yscC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3976 yscR from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239208 28373022 pYVa12790_p26 NP_783679.1 type III secretion system protein Virulence factor MUTATION: yscR mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3977 yscL from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239212 28373026 pYVa12790_p44 NP_783697.1 type III secretion system protein Virulence factor MUTATION: yscL mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3978 virG from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239217 28373031 pYVa12790_p30 NP_783683.1 VirG Virulence factor MUTATION: virG mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3979 virF from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239218 28373032 pYVa12790_p31 NP_783684.1 VirF Virulence factor MUTATION: virF mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3980 yadA from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239224 28372996 pYVa12790_p60 NP_783714.1 adhesin YadA Virulence factor MUTATION: yadA mutant is attenuated in mice [Ref6845:Di et al., 2003]. 12654794 3981 yopP from Yersinia enterocolitica A127/90 Yersinia enterocolitica A127/90 1239242 28373009 pYVa12790_p68 NP_783722.1 YopP Virulence factor MUTATION: yopP mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3984 lcrV from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449458 32470278 pYVe8081_p09 NP_863514.1 control of Yop release Virulence factor MUTATION: lcrV mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3985 yscR from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449471 32470292 pYVe8081_p22 NP_863527.1 required for Yop secretion Virulence factor MUTATION: yscR mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3986 yscU from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449474 32470295 pYVe8081_p25 NP_863530.1 required for Yop secretion Virulence factor MUTATION: yscU mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3987 virG from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449475 32470296 pYVe8081_p26 AY150843 NP_863531 VirG Virulence factor MUTATION: virG mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3988 virF from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449476 32470297 pYVe8081_p27 NP_863532.1 transcriptional activator VirF Virulence factor MUTATION: virF mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3989 yscC from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449479 32470300 pYVe8081_p30 NP_863535.1 required for Yop secretion Virulence factor MUTATION: yscC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3990 yscL from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449488 32470309 pYVe8081_p39 NP_863544.1 required for Yop secretion Virulence factor MUTATION: yscL mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 3991 sycH from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449491 32470312 pYVe8081_p42 NP_863547.1 YopH chaperone SycH Virulence factor MUTATION: sycH mutant is attenuated in mice [Ref6845:Di et al., 2003]. 12654794 3992 yadA from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449501 32470319 pYVe8081_p52 NP_863557.1 Adhesin Virulence factor MUTATION: yadA mutant is attenuated in mice [Ref6845:Di et al., 2003]. 12654794 3993 yopP from Yersinia enterocolitica 8081 Yersinia enterocolitica 8081 1449509 32470321 pYVe8081_p61 NP_863566.1 Yop effector YopP Virulence factor MUTATION: yopP mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 4006 lcrV from Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia enterocolitica subsp. enterocolitica 8081 4711837 122815803 YEP0015 YP_001004069.1 virulence-associated V antigen Virulence factor MUTATION: lcrV mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 4007 yscC from Yersinia enterocolitica subsp. enterocolitica 8081 YersiYersinia enterocolitica subsp. enterocolitica 8081 4711865 122815824 YEP0038 YP_001004090.1 putative type III secretion protein Virulence factor MUTATION: yscC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG1450NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10216859 4008 yscL from Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia enterocolitica subsp. enterocolitica 8081 4711885 122815833 YEP0047 YP_001004099.1 type III secretion system protein Virulence factor MUTATION: yscL mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG1317NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 10216859 4009 virG from Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia enterocolitica subsp. enterocolitica 8081 4711894 122815820 YEP0033 YP_001004086.1 putative type III secretion effector targeting lipoprotein Virulence factor MUTATION: virG mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 4010 yscU from Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia enterocolitica subsp. enterocolitica 8081 4711903 122815819 YEP0031 YP_001004085.1 putative type III secretion protein Virulence factor MUTATION: yscU mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG4792U, under U: Intracellular trafficking, secretion, and vesicular transport 10216859 4011 yscR from Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia enterocolitica subsp. enterocolitica 8081 4711911 122815816 YEP0028 YP_001004082.1 type III secretion system protein Virulence factor MUTATION: yscR mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG4790U, under U: Intracellular trafficking, secretion, and vesicular transport 10216859 4012 virF from Yersinia enterocolitica subsp. enterocolitica 8081 Yersinia enterocolitica subsp. enterocolitica 8081 4711913 122815821 YEP0035 YP_001004087.1 virulence regulon transcriptional activator Virulence factor MUTATION: virF mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG2207K, under K: Transcription 10216859 4013 pstC Yersinia enterocolitica subsp. enterocolitica 8081 4712699 123444367 YE4200 YP_001008332.1 phosphate transporter permease subunit PstC Virulence factor MUTATION: pstC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0573P, under P: Inorganic ion transport and metabolism 10216859 4014 dnaJ Yersinia enterocolitica subsp. enterocolitica 8081 4712915 123440975 YE0610 YP_001004964.1 chaperone protein DnaJ Virulence factor MUTATION: dnaJ mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0484O, under O: Posttranslational modification, protein turnover, chaperones 10216859 4015 pspC Yersinia enterocolitica subsp. enterocolitica 8081 4713518 123442380 YE2119 YP_001006359.1 DNA-binding transcriptional activator PspC Virulence factor MUTATION: pspC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG1983KT, under K: Transcription; T: Signal transduction mechanisms 10216859 4016 horYe Yersinia enterocolitica subsp. enterocolitica 8081 4713544 123442405 YE2144 YP_001006384.1 transcriptional regulator SlyA Virulence factor MUTATION: rovA mutant is attenuated when delivered orally in mice [Ref6870:Dube et al., 2003]. COG1846K, under K: Transcription 12761136 4017 irp1 Yersinia enterocolitica subsp. enterocolitica 8081 4714264 123442840 YE2618 YP_001006816.1 yersiniabactin biosynthetic protein Virulence factor MUTATION: irp1 mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG3321Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 10216859 4018 galE Yersinia enterocolitica subsp. enterocolitica 8081 4714558 123443279 YE3071 YP_001007253.1 UDP-glucose 4-epimerase Virulence factor MUTATION: galE mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG1087M, under M: Cell wall/membrane/envelope biogenesis 10216859 4019 manB Yersinia enterocolitica subsp. enterocolitica 8081 4714559 123443280 YE3072 YP_001007254.1 phosphomannomutase Virulence factor MUTATION: manB mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG1109G, under G: Carbohydrate transport and metabolism 10216859 4020 manC Yersinia enterocolitica subsp. enterocolitica 8081 4714560 123443281 YE3073 YP_001007255.1 mannose-1-phosphate guanylyltransferase Virulence factor MUTATION: manC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0836M, under M: Cell wall/membrane/envelope biogenesis 10216859 4021 rfpB Yersinia enterocolitica subsp. enterocolitica 8081 4714563 123443284 YE3076 YP_001007258.1 putative galactosyltransferase Virulence factor MUTATION: wcbI mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 10216859 4022 wbcH Yersinia enterocolitica subsp. enterocolitica 8081 4714564 123443285 YE3077 AM286415 YP_001007259 putative glycosyl transferase Virulence factor MUTATION: wbcH mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 4023 wbcF Yersinia enterocolitica subsp. enterocolitica 8081 4714566 123443287 YE3079 AM286415 YP_001007261 hypothetical protein Virulence factor MUTATION: wbcF mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. 10216859 4024 wbcC Yersinia enterocolitica subsp. enterocolitica 8081 4714570 123443291 YE3083 AM286415 YP_001007265 putative glycosyltransferase Virulence factor MUTATION: wbcC mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0463M, under M: Cell wall/membrane/envelope biogenesis 10216859 4025 ddhB Yersinia enterocolitica subsp. enterocolitica 8081 4714573 123443294 YE3086 AM286415 YP_001007268 CDP-glucose 4,6-dehydratase Virulence factor MUTATION: ddhB mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0451MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism 10216859 4026 htrB Yersinia enterocolitica subsp. enterocolitica 8081 4714987 123441919 YE1612 YP_001005902.1 lipid A biosynthesis lauroyl acyltransferase Virulence factor MUTATION: htrB mutant has diminished invasion of HeLa cells and is attenuated in vivo [Ref6871:Pérez-Gutiérrez et al., 2010]. COG1560M, under M: Cell wall/membrane/envelope biogenesis 20385763 4027 msbB Yersinia enterocolitica subsp. enterocolitica 8081 4715094 123442628 YE2386 YP_001006605.1 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase Virulence factor MUTATION: msbB mutant has diminished invasion of HeLa cells [Ref6871:Pérez-Gutiérrez et al., 2010]. COG1560M, under M: Cell wall/membrane/envelope biogenesis 20385763 4028 ddhA Yersinia enterocolitica subsp. enterocolitica 8081 4715407 123443295 YE3087 AM286415 YP_001007269 glucose-1-phosphate cytidylyltransferase Virulence factor MUTATION: ddhA mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG1208MJ, under M: Cell wall/membrane/envelope biogenesis; J: Translation, ribosomal structure and biogenesis 10216859 4029 supX Yersinia enterocolitica subsp. enterocolitica 8081 4715471 123442459 YE2199 YP_001006438.1 DNA topoisomerase I Virulence factor MUTATION: topA mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0550L, under L: Replication, recombination and repair 10216859 4030 degP Yersinia enterocolitica subsp. enterocolitica 8081 4715899 123441096 YE0741 AM286415 YP_001005085 serine endoprotease Virulence factor MUTATION: htrA mutant is avirulent in mice [Ref6872:Li et al., 1996]. COG0265O, under O: Posttranslational modification, protein turnover, chaperones 8675311 4031 nlpD Yersinia enterocolitica subsp. enterocolitica 8081 4716124 123441127 YE0774 YP_001005115.1 lipoprotein NlpD Virulence factor MUTATION: nlpD mutant is attenuated in mice [Ref6844:Darwin and Miller, 1999]. COG0739M, under M: Cell wall/membrane/envelope biogenesis 10216859 4032 ompR Yersinia enterocolitica subsp. enterocolitica 8081 4716266 123444180 YE4004 YP_001008150.1 osmolarity response regulator Virulence factor MUTATION: ompR mutant is unable to invade HeLa cells [Ref6873:Raczkowska and Brzostek, 2004]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 15330261 4938 aroA Yersinia enterocolitica subsp. enterocolitica 8081 4713234 123441850 YE1538 AM286415 YP_001005833 3-phosphoshikimate 1-carboxyvinyltransferase Virulence factor MUTATION: An aroA mutant is highly attenuated in mice [Ref7358:Bowe et al., 1989]. COG0128E, under E: Amino acid transport and metabolism 2777382 5015 sodA Yersinia enterocolitica subsp. enterocolitica 8081 4716532 123444307 YE4138 AM286415 YP_001008274 superoxide dismutase Virulence factor MUTATION: A sodA mutant in Yersinia enterocolitica was highly attenuated in mice [Ref7421:Igwe et al., 1999]. COG0605P, under P: Inorganic ion transport and metabolism 10496939