Protegen ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Protein Annotation Molecule Role Molecule Role Annotation COG PMID 403 FTL_0837 Francisella tularensis 3950826 89256197 FTL_0837 YP_513559.1 D-methionine binding transport protein, ABC transporter, membrane and periplasmic protein Virulence factor MUTATION: a FTL_0837 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1464P, under P: Inorganic ion transport and metabolism 17420240 404 FTL_0846 Francisella tularensis 3950835 89256206 FTL_0846 YP_513568.1 isochorismatase hydrolase family protein Virulence factor MUTATION: a FTL_0846 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1335Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 405 FTL_1528 Francisella tularensis 3950841 89256813 FTL_1528 YP_514175.1 major facilitator superfamily (MFS) transport protein Virulence factor MUTATION: a FTL_1528 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 406 FTL_1096 Francisella tularensis 3950886 89256426 FTL_1096 YP_513788.1 conserved hypothetical lipoprotein Virulence factor MUTATION: a FTL_1096 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1651O, under O: Posttranslational modification, protein turnover, chaperones 17420240 407 FTL_1097 Francisella tularensis 3950887 89256427 FTL_1097 YP_513789.1 macrophage infectivity potentiator, fragment Virulence factor MUTATION: a FTL_1097 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 408 FTL_1867 Francisella tularensis 3950914 89257122 FTL_1867 YP_514484.1 protease yegQ Virulence factor MUTATION: a FTL_1867 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0826O, under O: Posttranslational modification, protein turnover, chaperones 17420240 409 FTL_1672 Francisella tularensis 3950922 89256945 FTL_1672 YP_514307.1 Transporter AcrB/AcrD/AcrF family Virulence factor MUTATION: a FTL_1672 mutant was attenuated for infection of a mouse lung [Ref6340:Su et al., 2007] COG0841V, under V: Defense mechanisms 17420240 410 FTL_1678 Francisella tularensis 3950928 89256948 FTL_1678 YP_514310.1 conserved membrane hypothetical protein Virulence factor MUTATION: a FTL_1678 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1619V, under V: Defense mechanisms 17420240 411 tig from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3950940 89256248 FTL_0891 YP_513610.1 trigger factor Virulence factor MUTATION: a tig mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0544O, under O: Posttranslational modification, protein turnover, chaperones 17420240 412 FTL_0892 Francisella tularensis 3950941 89256249 FTL_0892 YP_513611.1 ATP-dependent Clp protease subunit P Virulence factor MUTATION: a FTL_0892 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 17420240 413 clpX Francisella tularensis 3950942 89256250 FTL_0893 YP_513612.1 ATP-dependent protease ATP-binding subunit Virulence factor MUTATION: a clpX mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1219O, under O: Posttranslational modification, protein turnover, chaperones 17420240 414 FTL_0894 Francisella tularensis 3950943 89256251 FTL_0894 YP_513613.1 DNA-binding, ATP-dependent protease La Virulence factor MUTATION: a FTL_0894 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0466O, under O: Posttranslational modification, protein turnover, chaperones 17420240 415 FTL_0899 Francisella tularensis 3950948 89256256 FTL_0899 YP_513618.1 protease, GTP-binding subunit Virulence factor MUTATION: a FTL_0899 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2262R, under R: General function prediction only 17420240 416 FTL_0903 Francisella tularensis 3950952 89256260 FTL_0903 YP_513622.1 SPFH domain, band 7 family protein Virulence factor MUTATION: a FTL_0903 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0330O, under O: Posttranslational modification, protein turnover, chaperones 17420240 417 FTL_0483 Francisella tularensis 3950981 89255893 FTL_0483 YP_513255.1 glycogen branching enzyme Virulence factor MUTATION: a FTL_0483 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0296G, under G: Carbohydrate transport and metabolism 17420240 418 FTL_0485 Francisella tularensis 3950983 89255895 FTL_0485 YP_513257.1 Glucose-1-phosphate adenylyltransferase Virulence factor MUTATION: a FTL_0485 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0448G, under G: Carbohydrate transport and metabolism 17420240 419 FTL_1134 Francisella tularensis 3951041 89256459 FTL_1134 YP_513821.1 hypothetical protein Virulence factor MUTATION: a FTL_1134 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 420 FTL_1030 Francisella tularensis 3951097 89256369 FTL_1030 YP_513731.1 ribosomal large subunit pseudouridine synthase B Virulence factor MUTATION: a FTL_1030 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1187J, under J: Translation, ribosomal structure and biogenesis 17420240 421 FTL_0768 Francisella tularensis 3951135 89256151 FTL_0768 YP_513513.1 GTP binding translational elongation factor Tu and G family protein Virulence factor MUTATION: a FTL_0768 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1217T, under T: Signal transduction mechanisms 17420240 422 FTL_0584 Francisella tularensis 3951196 89255982 FTL_0584 YP_513344.1 fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein Virulence factor MUTATION: a FTL_0584 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1250I, under I: Lipid transport and metabolism 17420240 423 FTL_0421 Francisella tularensis 3951237 89255832 FTL_0421 YP_513194.1 conserved hypothetical lipoprotein Virulence factor MUTATION: a FTL_0421 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 424 FTL_0428 Francisella tularensis 3951244 89255838 FTL_0428 YP_513200.1 chromosome partition protein B Virulence factor MUTATION: a FTL_0428 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1475K, under K: Transcription 17420240 425 FTL_0430 Francisella tularensis 3951246 89255840 FTL_0430 YP_513202.1 hypothetical protein Virulence factor MUTATION: a FTL_0430 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3240IR, under I: Lipid transport and metabolism; R: General function prediction only 17420240 426 FTL_0439 Francisella tularensis 3951255 89255849 FTL_0439 YP_513211.1 hypothetical protein Virulence factor MUTATION: a FTL_0439 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 427 FTL_0950 Francisella tularensis 3951256 89256299 FTL_0950 YP_513661.1 50S ribosomal protein L25 Virulence factor MUTATION: a FTL_0950 mutant was attenuated for infection in a mouse lung[Ref6340:Su et al., 2007] COG1825J, under J: Translation, ribosomal structure and biogenesis 17420240 428 FTL_0960 Francisella tularensis 3951266 89256309 FTL_0960 YP_513671.1 soluble pyridine nucleotide transhydrogenase Virulence factor MUTATION: a FTL_0960 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1249C, under C: Energy production and conversion 17420240 429 rpmJ from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3951279 89255691 FTL_0257 YP_513052.1 50S ribosomal protein L36 Virulence factor MUTATION: a rpmJ mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 430 FTL_0616 Francisella tularensis 3951342 89256013 FTL_0616 YP_513375.1 DNA-directed RNA polymerase subunit alpha Virulence factor MUTATION: a FTL_0616 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0202K, under K: Transcription 17420240 431 FTL_0617 Francisella tularensis 3951343 89256014 FTL_0617 YP_513376.1 hypothetical protein Virulence factor MUTATION: a FTL_0617 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2193P, under P: Inorganic ion transport and metabolism 17420240 432 FTL_0009 Francisella tularensis 3951375 89255458 FTL_0009 YP_512819.1 outer membrane protein Virulence factor MUTATION: a FTL_0009 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2825M, under M: Cell wall/membrane/envelope biogenesis 17420240 433 FTL_0010 Francisella tularensis 3951376 89255459 FTL_0010 YP_512820.1 thiosulfate sulfurtransferase Virulence factor MUTATION: a FTL_0010 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0607P, under P: Inorganic ion transport and metabolism 17420240 434 FTL_0012 Francisella tularensis 3951378 89255461 FTL_0012 YP_512822.1 Recombinase A protein Virulence factor MUTATION: a FTL_0012 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0468L, under L: Replication, recombination and repair 17420240 435 secE Francisella tularensis 3951407 89257019 FTL_1750 YP_514381.1 preprotein translocase subunit SecE Virulence factor MUTATION: a secE mutant was attenuated for infection of a mouse lung [Ref6340:Su et al., 2007] 17420240 436 FTL_0663 Francisella tularensis 3951501 89256053 FTL_0663 YP_513415.1 hypothetical protein Virulence factor MUTATION: a FTL_0663 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 437 FTL_1233 Francisella tularensis 3951508 89256552 FTL_1233 YP_513914.1 amino acid antiporter Virulence factor MUTATION: a FTL_1233 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0531E, under E: Amino acid transport and metabolism 17420240 438 FTL_1240 Francisella tularensis 3951515 89256558 FTL_1240 YP_513920.1 phospho-2-dehydro-3-heoxyheptonate aldolase Virulence factor MUTATION: a FTL_1240 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0722E, under E: Amino acid transport and metabolism 17420240 439 FTL_1225 Francisella tularensis 3951539 89256546 FTL_1225 YP_513908.1 hypothetical protein Virulence factor MUTATION: a FTL_1225 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 440 FTL_0645 Francisella tularensis 3951562 89256036 FTL_0645 YP_513398.1 hypothetical lipoprotein Virulence factor MUTATION: a FTL_0645 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 441 FTL_0723 Francisella tularensis 3951617 89256112 FTL_0723 YP_513474.1 hypothetical protein Virulence factor MUTATION: a FTL_0723 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0271T, under T: Signal transduction mechanisms 17420240 442 FTL_1419 Francisella tularensis 3951644 89256712 FTL_1419 YP_514074.1 Cyanophycinase Virulence factor MUTATION: a FTL_1419 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG4242QP, under Q: Secondary metabolites biosynthesis, transport and catabolism; P: Inorganic ion transport and metabolism 17420240 443 FTL_0803 Francisella tularensis 3951675 89256173 FTL_0803 YP_513535.1 hypothetical protein Virulence factor MUTATION: a FTL_0803 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 444 FTL_1075 Francisella tularensis 3951705 89256410 FTL_1075 YP_513772.1 hypothetical protein Virulence factor MUTATION: a FTL_1075 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 445 FTL_0111 Francisella tularensis 3951721 89255548 FTL_0111 YP_512909.1 intracellular growth locus, subunit A Virulence factor MUTATION: a FTL_0111 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3516S, under S: Function unknown 17420240 446 FTL_0112 Francisella tularensis 3951722 89255549 FTL_0112 YP_512910.1 intracellular growth locus, subunit B Virulence factor MUTATION: a FTL_0112 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3517S, under S: Function unknown 17420240 447 FTL_0113 Francisella tularensis 3951723 89255550 FTL_0113 YP_512911.1 intracellular growth locus, subunit C Virulence factor MUTATION: a FTL_0113 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 448 FTL_0133 Francisella tularensis 3951742 89255570 FTL_0133 YP_512931.1 ferrous iron transport protein Virulence factor MUTATION: a FTL_0133 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0370P, under P: Inorganic ion transport and metabolism 17420240 449 FTL_1354 Francisella tularensis 3951776 89256655 FTL_1354 YP_514017.1 hypothetical protein Virulence factor MUTATION: a FTL_1354 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG5006R, under R: General function prediction only 17420240 450 sucC from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3951826 89256837 FTL_1553 YP_514199.1 succinyl-CoA synthetase subunit beta Virulence factor MUTATION: a sucC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0045C, under C: Energy production and conversion 17420240 451 FTL_1554 Francisella tularensis 3951827 89256838 FTL_1554 YP_514200.1 Succinyl-CoA synthetase, alpha subunit Virulence factor MUTATION: a FTL_1554 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0074C, under C: Energy production and conversion 17420240 452 FTL_0193 Francisella tularensis 3951917 89255627 FTL_0193 YP_512988.1 Cytochrome O ubiquinol oxidase, subunit III Virulence factor MUTATION: a FTL_0193 mutant was attenuated for infection in a mouse lung COG1845C, under C: Energy production and conversion 453 FTL_1601 Francisella tularensis 3951951 89256878 FTL_1601 YP_514240.1 tRNA/rRNA methyltransferase Virulence factor MUTATION: a FTL_1601 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0219J, under J: Translation, ribosomal structure and biogenesis 17420240 454 FTL_1273 Francisella tularensis 3951957 89256582 FTL_1273 YP_513944.1 8-amino-7-oxononanoate synthase Virulence factor MUTATION: a FTL_1273 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0156H, under H: Coenzyme transport and metabolism 17420240 455 FTL_1274 Francisella tularensis 3951958 89256583 FTL_1274 YP_513945.1 biotin synthesis protein BioC Virulence factor MUTATION: a FTL_1274 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 456 FTL_1275 Francisella tularensis 3951959 89256584 FTL_1275 YP_513946.1 dethiobiotin synthetase Virulence factor MUTATION: a FTL_1275 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0132H, under H: Coenzyme transport and metabolism 17420240 457 FTL_1936 Francisella tularensis 3951994 89257177 FTL_1936 YP_514539.1 periplasmic solute binding family protein Virulence factor MUTATION: a FTL_1936 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0803P, under P: Inorganic ion transport and metabolism 17420240 458 FTL_1622 Francisella tularensis 3952010 89256899 FTL_1622 YP_514261.1 multidrug transporter (tetracycline resistance protein) Virulence factor MUTATION: a FTL_1622 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2814G, under G: Carbohydrate transport and metabolism 17420240 459 FTL_1623 Francisella tularensis 3952011 89256900 FTL_1623 YP_514262.1 hypothetical protein Virulence factor MUTATION: a FTL_1623 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1289S, under S: Function unknown 17420240 460 rpmA from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3952026 89256745 FTL_1452 YP_514107.1 50S ribosomal protein L27 Virulence factor MUTATION: a rpmA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0211J, under J: Translation, ribosomal structure and biogenesis 17420240 461 FTL_1458 Francisella tularensis 3952032 89256747 FTL_1458 YP_514109.1 preprotein translocase subunit SecA Virulence factor MUTATION: a FTL_1458 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0653U, under U: Intracellular trafficking, secretion, and vesicular transport 17420240 462 FTL_R0003 Francisella tularensis 3952047 0 FTL_R0003 - 16S ribosomal RNA Virulence factor MUTATION: a FTL_R0003 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 463 FTL_1504 Francisella tularensis 3952054 89256792 FTL_1504 YP_514154.1 Peroxidase/catalase Virulence factor MUTATION: a FTL_1504 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0376P, under P: Inorganic ion transport and metabolism 17420240 464 FTL_1266 Francisella tularensis 3952087 89256578 FTL_1266 YP_513940.1 Lipase/esterase Virulence factor MUTATION: a FTL_1266 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0657I, under I: Lipid transport and metabolism 17420240 465 FTL_0928 Francisella tularensis 3952111 89256279 FTL_0928 YP_513641.1 isoprenoid biosynthesis protein with amidotransferase-like domain Virulence factor MUTATION: a FTL_0928 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3155Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 466 rpsA from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3952147 89257160 FTL_1912 YP_514522.1 30S ribosomal protein S1 Virulence factor MUTATION: a rpsA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0539J, under J: Translation, ribosomal structure and biogenesis 17420240 467 glpX from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3952178 89256970 FTL_1701 YP_514332.1 fructose 1,6-bisphosphatase II Virulence factor MUTATION: a glpX mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1494G, under G: Carbohydrate transport and metabolism 17420240 468 FTL_0514 Francisella tularensis 3952219 89255921 FTL_0514 YP_513283.1 hypothetical protein Virulence factor MUTATION: a FTL_0514 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2854Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 469 FTL_0519 Francisella tularensis 3952224 89255926 FTL_0519 YP_513288.1 septum site-determining protein MinD Virulence factor MUTATION: a FTL_0519 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2894D, under D: Cell cycle control, cell division, chromosome partitioning 17420240 470 FTL_0520 Francisella tularensis 3952225 89255927 FTL_0520 YP_513289.1 septum site-determining protein MinC Virulence factor MUTATION: a FTL_0520 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0850D, under D: Cell cycle control, cell division, chromosome partitioning 17420240 471 FTL_0094 Francisella tularensis 3952271 89255534 FTL_0094 YP_512895.1 ClpB protein Virulence factor MUTATION: a FTL_0094 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0542O, under O: Posttranslational modification, protein turnover, chaperones 17420240 472 rpsU from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3952320 89255866 FTL_0456 YP_513228.1 30S ribosomal protein S21 Virulence factor MUTATION: a rpsU mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0828J, under J: Translation, ribosomal structure and biogenesis 17420240 473 rplT from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3952390 89256697 FTL_1404 YP_514059.1 50S ribosomal protein L20 Virulence factor MUTATION: a rplT mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0292J, under J: Translation, ribosomal structure and biogenesis 17420240 474 FTL_1414 Francisella tularensis 3952400 89256707 FTL_1414 YP_514069.1 hypothetical protein Virulence factor MUTATION: a FTL_1414 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 475 FTL_1415 Francisella tularensis 3952401 89256708 FTL_1415 YP_514070.1 capsule biosynthesis protein CapC Virulence factor MUTATION: a FTL_1415 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 476 FTL_1416 Francisella tularensis 3952402 89256709 FTL_1416 YP_514071.1 capsule biosynthesis protein capB Virulence factor MUTATION: a FTL_1416 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0769M, under M: Cell wall/membrane/envelope biogenesis 17420240 477 FTL_1832 Francisella tularensis 3952442 89257092 FTL_1832 YP_514454.1 hypothetical protein Virulence factor MUTATION: a FTL_1832 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG4264Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 478 isftu1 from Francisella tularensis subsp. holarctica LVS Francisella tularensis subsp. holarctica LVS 3952464 89255850 FTL_0440 YP_513212.1 Transposase Virulence factor MUTATION: a isftu1 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3335L, under L: Replication, recombination and repair 17420240 479 FTL_1461 Francisella tularensis 3952483 89256750 FTL_1461 YP_514112.1 purine nucleoside phosphorylase Virulence factor MUTATION: a FTL_1461 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0813F, under F: Nucleotide transport and metabolism 17420240 480 FTL_1473 Francisella tularensis 3952491 89256762 FTL_1473 YP_514124.1 DNA excision repair enzyme, subunit A Virulence factor MUTATION: a FTL_1473 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0178L, under L: Replication, recombination and repair 17420240 481 FTL_1474 Francisella tularensis 3952492 89256763 FTL_1474 YP_514125.1 transcriptional elongation factor Virulence factor MUTATION: a FTL_1474 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0782K, under K: Transcription 17420240 482 FTL_1475 Francisella tularensis 3952493 89256764 FTL_1475 YP_514126.1 Type IV pili fiber building block protein Virulence factor MUTATION: a FTL_1475 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 483 tRNA-Ile1 Francisella tularensis 3952505 0 FTL_R0004 - tRNA Virulence factor MUTATION: a tRNA-Ile1 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 484 FTL_0382 Francisella tularensis 3952562 89255796 FTL_0382 YP_513158.1 amino acid permease Virulence factor MUTATION: a FTL_0382 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0833E, under E: Amino acid transport and metabolism 17420240 485 FTL_0387 Francisella tularensis 3952567 89255798 FTL_0387 YP_513160.1 aspartate aminotransferase Virulence factor MUTATION: a FTL_0387 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0436E, under E: Amino acid transport and metabolism 17420240 486 FTL_1947 Francisella tularensis 3952586 89257186 FTL_1947 YP_514548.1 putative ABC transporter ATP-binding protein Virulence factor MUTATION: a FTL_1947 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0488R, under R: General function prediction only 17420240 487 FTL_1328 Francisella tularensis 3952608 89256632 FTL_1328 YP_513994.1 outer membrane associated protein Virulence factor MUTATION: a FTL_1328 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2885M, under M: Cell wall/membrane/envelope biogenesis 17420240 488 FTL_0073 Francisella tularensis 3952648 89255516 FTL_0073 YP_512877.1 hypothetical membrane protein Virulence factor MUTATION: a FTL_0073 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 489 FTL_0525 Francisella tularensis 3952665 89255932 FTL_0525 YP_513294.1 fumerate hydratase Virulence factor MUTATION: a FTL_0525 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1951C, under C: Energy production and conversion 17420240 490 FTL_0540 Francisella tularensis 3952679 89255947 FTL_0540 YP_513309.1 Lipid-A-disaccharide synthase Virulence factor MUTATION: a FTL_0540 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0763M, under M: Cell wall/membrane/envelope biogenesis 17420240 491 FTL_0337 Francisella tularensis 3952683 0 FTL_0337 - pseudo Virulence factor MUTATION: a FTL_0337 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 492 FTL_1392 Francisella tularensis 3952716 89256685 FTL_1392 YP_514047.1 Cold-shock DEAD-box protein A Virulence factor MUTATION: a FTL_1392 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0513LKJ, under L: Replication, recombination and repair; K: Transcription; J: Translation, ribosomal structure and biogenesis 17420240 493 FTL_1393 Francisella tularensis 3952717 89256686 FTL_1393 YP_514048.1 Peptidyl-prolyl cis-trans isomerase. Virulence factor MUTATION: a FTL_1393 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0760O, under O: Posttranslational modification, protein turnover, chaperones 17420240 494 FTL_0589 Francisella tularensis 3952784 89255987 FTL_0589 YP_513349.1 hypothetical membrane protein Virulence factor MUTATION: a FTL_0589 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 495 FTL_0592 Francisella tularensis 3952786 89255990 FTL_0592 YP_513352.1 dTDP-glucose 4,6-dehydratase Virulence factor MUTATION: a FTL_0592 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1086MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism 17420240 496 FTL_0597 Francisella tularensis 3952791 89255995 FTL_0597 YP_513357.1 NAD dependent epimerase Virulence factor MUTATION: a FTL_0597 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0451MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism 17420240 497 FTL_0789 Francisella tularensis 3952837 89256162 FTL_0789 YP_513524.1 aspartate aminotransferase Virulence factor MUTATION: a FTL_0789 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0436E, under E: Amino acid transport and metabolism 17420240 545 FTT0054 Francisella tularensis 3190705 56707233 FTT0054 YP_169129.1 ATPase Virulence factor MUTATION: FTT0054 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1485R, under R: General function prediction only 17389372 546 sodB Francisella tularensis 3190713 56707247 FTT0068 YP_169143.1 superoxide dismutase (Fe) Virulence factor MUTATION: sodB mutant is attenuated in mice [Ref6383:Bakshi et al., 2006]. COG0605P, under P: Inorganic ion transport and metabolism 16923916 547 sthA Francisella tularensis 3190728 56707804 FTT0684c YP_169700.1 soluble pyridine nucleotide transhydrogenase Virulence factor MUTATION: a sthA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1249C, under C: Energy production and conversion 17420240 548 sucC from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3190738 56707643 FTT0504c YP_169539.1 succinyl-CoA synthetase subunit beta Virulence factor MUTATION: a sucC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0045C, under C: Energy production and conversion 17420240 549 sucB Francisella tularensis 3190739 56707256 FTT0077 YP_169152.1 dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex Virulence factor MUTATION: sucB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0508C, under C: Energy production and conversion 17389372 550 sucD Francisella tularensis 3190740 56707642 FTT0503c YP_169538.1 Succinyl-CoA synthetase, alpha subunit Virulence factor MUTATION: a sucD mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0074C, under C: Energy production and conversion 17420240 551 ksgA Francisella tularensis 3190742 56707611 FTT0469 YP_169507.1 dimethyladenosine transferase Virulence factor MUTATION: ksgA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0030J, under J: Translation, ribosomal structure and biogenesis 17389372 552 surA Francisella tularensis 3190745 56707610 FTT0468 YP_169506.1 Peptidyl-prolyl cis-trans isomerase (PPIase) Virulence factor MUTATION: surA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0760O, under O: Posttranslational modification, protein turnover, chaperones 17389372 553 FTT0105c Francisella tularensis 3190746 56707279 FTT0105c YP_169175.1 Transporter AcrB/AcrD/AcrF family Virulence factor MUTATION: a FTT0105c mutant was attenuated for infection of a mouse lung [Ref6340:Su et al., 2007] COG0841V, under V: Defense mechanisms 17420240 554 tet Francisella tularensis 3190751 56707587 FTT0444 YP_169483.1 multidrug transporter (tetracycline resistance protein) Virulence factor MUTATION: a tet mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2814G, under G: Carbohydrate transport and metabolism 17420240 555 glgB Francisella tularensis 3190770 56707562 FTT0413c YP_169458.1 glycogen branching enzyme Virulence factor MUTATION: a glgB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0296G, under G: Carbohydrate transport and metabolism 17420240 556 FTT0134 Francisella tularensis 3190771 56707305 FTT0134 YP_169201.1 hypothetical membrane protein Virulence factor MUTATION; FTT0134 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 557 tig from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3190785 56707748 FTT0623 YP_169644.1 trigger factor Virulence factor MUTATION: a tig mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0544O, under O: Posttranslational modification, protein turnover, chaperones 17420240 558 FTT1441 Francisella tularensis 3190796 56708483 FTT1441 YP_170379.1 hypothetical protein Virulence factor MUTATION: a FTT1441 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2193P, under P: Inorganic ion transport and metabolism 17420240 559 lon Francisella tularensis 3190802 56707751 FTT0626 YP_169647.1 DNA-binding, ATP-dependent protease La Virulence factor MUTATION: a lon mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0466O, under O: Posttranslational modification, protein turnover, chaperones 17420240 560 lpnB Francisella tularensis 3190834 56708005 FTT0904 YP_169901.1 conserved hypothetical lipoprotein Virulence factor MUTATION: lpnB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 561 FTT1489 Francisella tularensis 3190835 56708528 FTT1489 YP_170424.1 hypothetical protein Virulence factor MUTATION: FTT1489 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 562 FTT1400c Francisella tularensis 3190879 56708448 FTT1400c YP_170344.1 hypothetical protein Virulence factor MUTATION: a FTT1400c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 563 FTT0975 Francisella tularensis 3190902 56708067 FTT0975 YP_169963.1 hypothetical protein Virulence factor MUTATION: a FTT0975 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 564 isftu1 from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3190914 56708021 FTT0920 YP_169917.1 Transposase Virulence factor MUTATION: a isftu1 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3415L, under L: Replication, recombination and repair 17420240 565 metIQ Francisella tularensis 3190931 56708202 FTT1125 YP_170098.1 D-methionine binding transport protein, ABC transporter, membrane and periplasmic protein Virulence factor MUTATION: a metlQ mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1464P, under P: Inorganic ion transport and metabolism 17420240 566 glpe Francisella tularensis 3190942 56708746 FTT1748 YP_170642.1 thiosulfate sulfurtransferase Virulence factor MUTATION: a glpe mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0607P, under P: Inorganic ion transport and metabolism 17420240 567 aroG Francisella tularensis 3190950 56708057 FTT0963c YP_169953.1 phospho-2-dehydro-3-heoxyheptonate aldolase Virulence factor MUTATION: a aroG mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0722E, under E: Amino acid transport and metabolism 17420240 568 aspC1 Francisella tularensis 3190956 56707985 FTT0884c YP_169881.1 aspartate aminotransferase Virulence factor MUTATION: a aspC1 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0436E, under E: Amino acid transport and metabolism 17420240 569 cdd Francisella tularensis 3190961 56708384 FTT1327 YP_170280.1 cytidine deaminase Virulence factor MUTATION: cdd mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0295F, under F: Nucleotide transport and metabolism 17389372 570 bioD Francisella tularensis 3190963 56708031 FTT0934c YP_169927.1 dethiobiotin synthetase Virulence factor MUTATION: a bioD mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0132H, under H: Coenzyme transport and metabolism 17420240 571 bioC Francisella tularensis 3190965 56708032 FTT0935c YP_169928.1 biotin synthesis protein BioC Virulence factor MUTATION: a bioC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 572 bipA Francisella tularensis 3190966 56708247 FTT1179 YP_170143.1 GTP binding translational elongation factor Tu and G family protein Virulence factor MUTATION: a bipA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1217T, under T: Signal transduction mechanisms 17420240 573 glgC Francisella tularensis 3190967 0 FTT0415 - pseudo Virulence factor MUTATION: a glgC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 574 bioB Francisella tularensis 3190968 56708034 FTT0937c YP_169930.1 biotin synthase Virulence factor MUTATION: bioB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0502H, under H: Coenzyme transport and metabolism 17389372 575 capB Francisella tularensis 3190971 56707916 FTT0805 YP_169812.1 capsule biosynthesis protein capB Virulence factor MUTATION: a capB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0769M, under M: Cell wall/membrane/envelope biogenesis 17420240 576 bioF Francisella tularensis 3190975 56708033 FTT0936c YP_169929.1 8-amino-7-oxononanoate synthase Virulence factor MUTATION: a bioF mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0156H, under H: Coenzyme transport and metabolism 17420240 577 trpG Francisella tularensis 3190985 56708043 FTT0946 YP_169939.1 anthranilate synthase component II Virulence factor MUTATION: trpG mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0512EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism 17389372 578 FTT0708 Francisella tularensis 3191024 56707827 FTT0708 YP_169723.1 major facilitator superfamily (MFS) transport protein Virulence factor MUTATION: a FTT0708 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 579 FTT0685c Francisella tularensis 3191036 56707805 FTT0685c YP_169701.1 potassium channel protein Virulence factor MUTATION: FTT0685c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2898S, under S: Function unknown 17389372 580 FTT0667 Francisella tularensis 3191053 56707788 FTT0667 YP_169684.1 hypothetical protein Virulence factor MUTATION: FTT0667 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1335Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17389372 581 FTT0645c Francisella tularensis 3191066 56707767 FTT0645c YP_169663.1 hypothetical protein Virulence factor MUTATION: FTT0645c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0670R, under R: General function prediction only 17389372 582 carA Francisella tularensis 3191074 56708674 FTT1663 YP_170570.1 carbamoyl phosphate synthase small subunit Virulence factor MUTATION: carA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0505EF, under E: Amino acid transport and metabolism; F: Nucleotide transport and metabolism 17389372 583 FTT1633c Francisella tularensis 3191087 56708650 FTT1633c YP_170546.1 amino acid transporter Virulence factor MUTATION: FTT1633c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0833E, under E: Amino acid transport and metabolism 17389372 584 FTT1640c Francisella tularensis 3191099 0 FTT1640c - pseudo Virulence factor MUTATION: FTT1640c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 585 FTT1314c Francisella tularensis 3191109 56708371 FTT1314c YP_170267.1 Type IV pili fiber building block protein Virulence factor MUTATION: a FTT1314c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG4970NU, under N: Cell motility; U: Intracellular trafficking, secretion, and vesicular transport 17420240 586 FTT1611 Francisella tularensis 3191122 56708630 FTT1611 YP_170526.1 hypothetical protein Virulence factor MUTATION: a FTT1611 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2854Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 587 FTT1334c Francisella tularensis 3191128 56708390 FTT1334c YP_170286.1 hypothetical protein Virulence factor MUTATION: FTT1334c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 588 FTT0615c Francisella tularensis 3191148 56707740 FTT0615c YP_169636.1 metal ion transporter protein Virulence factor MUTATION: FTT0615c mutant is attenuated in mice [Ref6382:Weiss et al., 2007]. COG4535P, under P: Inorganic ion transport and metabolism 17389372 589 FTT0589 Francisella tularensis 3191174 56707716 FTT0589 YP_169612.1 hypothetical protein Virulence factor MUTATION: FTT0589 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 590 FTT0584 Francisella tularensis 3191177 56707712 FTT0584 YP_169608.1 hypothetical protein Virulence factor MUTATION: FTT0584 mutant is severely attenuated in mice [Ref6382:Weiss et al., 2007]. 17389372 591 iglA Francisella tularensis 3191217 56708415 FTT1359c YP_170311.1 intracellular growth locus, subunit A Virulence factor MUTATION: an iglA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3516S, under S: Function unknown 17420240 592 prfC Francisella tularensis 3191238 56707292 FTT0118 YP_169188.1 peptide chain release factor 3 Virulence factor MUTATION: prfC mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG4108J, under J: Translation, ribosomal structure and biogenesis 17389372 593 FTT1117c Francisella tularensis 3191243 56708195 FTT1117c YP_170091.1 isochorismatase hydrolase family protein Virulence factor MUTATION: a FTT1117c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1335Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 594 mtn Francisella tularensis 3191248 56707546 FTT0397 YP_169442.1 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Virulence factor MUTATION: mtn mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0775F, under F: Nucleotide transport and metabolism 17389372 595 FTT1103 Francisella tularensis 3191250 56708183 FTT1103 YP_170079.1 conserved hypothetical lipoprotein Virulence factor MUTATION: a FTT1103 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1651O, under O: Posttranslational modification, protein turnover, chaperones 17420240 596 FTT1102 Francisella tularensis 3191253 0 FTT1102 - pseudo Virulence factor MUTATION: a FTT1102 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 597 rpsU from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3191264 56707539 FTT0390c YP_169435.1 30S ribosomal protein S21 Virulence factor MUTATION: a rpsU mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 598 cadA Francisella tularensis 3191271 56707555 FTT0406 YP_169451.1 lysine decarboxylase, inducable Virulence factor MUTATION: cadA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1982E, under E: Amino acid transport and metabolism 17389372 599 yibK Francisella tularensis 3191278 56707605 FTT0463 YP_169501.1 tRNA/rRNA methyltransferase Virulence factor MUTATION: a yibK mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0219J, under J: Translation, ribosomal structure and biogenesis 17420240 600 pcs Francisella tularensis 3191290 56708590 FTT1563 YP_170486.1 phosphatidylcholine synthase Virulence factor MUTATION: pcs mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1183I, under I: Lipid transport and metabolism 17389372 601 ruvB Francisella tularensis 3191291 56708102 FTT1013c YP_169998.1 Holliday junction DNA helicase B Virulence factor MUTATION: ruvB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2255L, under L: Replication, recombination and repair 17389372 602 FTT0295 Francisella tularensis 3191293 56707448 FTT0295 YP_169344.1 hypothetical protein Virulence factor MUTATION: FTT0295 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 603 pdpA Francisella tularensis 3191294 56708400 FTT1344 YP_170296.1 hypothetical protein Virulence factor MUTATION: pdpA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 604 pdpB Francisella tularensis 3191301 56708401 FTT1345 YP_170297.1 hypothetical protein Virulence factor MUTATION: pdpB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG3523S, under S: Function unknown 17389372 605 pdxY Francisella tularensis 3191321 56707442 FTT0288c YP_169338.1 Pyridoxal/pyridoxine/pyridoxamine kinase Virulence factor MUTATION: pdxY mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2240H, under H: Coenzyme transport and metabolism 17389372 606 FTT0256c Francisella tularensis 3191322 56707412 FTT0256c YP_169308.1 Lipopolysaccharide protein Virulence factor MUTATION: FTT0256c mutant is attenuated in mice [Ref6382:Weiss et al., 2007]. 17389372 607 FTT0209c Francisella tularensis 3191350 56707372 FTT0209c YP_169268.1 periplasmic solute binding family protein Virulence factor MUTATION: a FTT0209c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0803P, under P: Inorganic ion transport and metabolism 17420240 608 pgm Francisella tularensis 3191363 56707563 FTT0414 YP_169459.1 phosphoglucomutase Virulence factor MUTATION: pgm mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0033G, under G: Carbohydrate transport and metabolism 17389372 609 FTT0509c Francisella tularensis 3191380 56707648 FTT0509c YP_169544.1 hypothetical protein Virulence factor MUTATION: FTT0509c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 610 sdhC Francisella tularensis 3191400 56707251 FTT0072 YP_169147.1 succinate dehydrogenase, cytochrome b556 Virulence factor MUTATION: sdhC mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2009C, under C: Energy production and conversion 17389372 611 FTT0455c Francisella tularensis 3191408 56707597 FTT0455c YP_169493.1 Dolichyl-phosphate-mannose-protein mannosyltransferase family protein Virulence factor MUTATION: FTT0455c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1807M, under M: Cell wall/membrane/envelope biogenesis 17389372 612 parB Francisella tularensis 3191409 56708009 FTT0908 YP_169905.1 chromosome partition protein B Virulence factor MUTATION: a parB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1475K, under K: Transcription 17420240 613 FTT0453c Francisella tularensis 3191411 56707595 FTT0453c YP_169491.1 hypothetical protein Virulence factor MUTATION: FTT0453c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG3394S, under S: Function unknown 17389372 614 FTT0443 Francisella tularensis 3191417 56707586 FTT0443 YP_169482.1 hypothetical protein Virulence factor MUTATION: a FTT0443 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1289S, under S: Function unknown 17420240 615 FTT0398c Francisella tularensis 3191430 56707547 FTT0398c YP_169443.1 hypothetical membrane protein Virulence factor MUTATION: FTT0398c mutant is mildly attenuated in mice [Ref6382:Weiss et al., 2007]. 17389372 616 FTT0399c Francisella tularensis 3191433 56707548 FTT0399c YP_169444.1 BNR/Asp-box repeat protein Virulence factor MUTATION: FTT0399c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG4692G, under G: Carbohydrate transport and metabolism 17389372 617 pcp Francisella tularensis 3191452 56707449 FTT0296 YP_169345.1 Pyrrolidone-carboxylate peptidase Virulence factor MUTATION: pcp mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2039O, under O: Posttranslational modification, protein turnover, chaperones 17389372 618 FTT1258 Francisella tularensis 3191474 56708320 FTT1258 YP_170216.1 outer membrane efflux protein Virulence factor MUTATION: FTT1258 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1538MU, under M: Cell wall/membrane/envelope biogenesis; U: Intracellular trafficking, secretion, and vesicular transport 17389372 619 htpG Francisella tularensis 3191490 56707508 FTT0356 YP_169404.1 heat shock protein 90 Virulence factor MUTATION: htpG mutant is strongly attenuated in mice [Ref6382:Weiss et al., 2007]. COG0326O, under O: Posttranslational modification, protein turnover, chaperones 17389372 620 deaD Francisella tularensis 3191508 56708511 FTT1471c YP_170407.1 Cold-shock DEAD-box protein A Virulence factor MUTATION: a deaD mutant was attenuated for infection in a mosue lung [Ref6340:Su et al., 2007] COG0513LKJ, under L: Replication, recombination and repair; K: Transcription; J: Translation, ribosomal structure and biogenesis 17420240 621 dedA1 Francisella tularensis 3191510 56708285 FTT1223 YP_170181.1 DedA family protein Virulence factor MUTATION: dedA1 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0586S, under S: Function unknown 17389372 622 deoB Francisella tularensis 3191513 56707287 FTT0113 YP_169183.1 phosphopentomutase Virulence factor MUTATION: deoB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1015G, under G: Carbohydrate transport and metabolism 17389372 623 deoD Francisella tularensis 3191517 56707880 FTT0766 YP_169776.1 purine nucleoside phosphorylase Virulence factor MUTATION: a deoD mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0813F, under F: Nucleotide transport and metabolism 17420240 624 fumA Francisella tularensis 3191534 56708620 FTT1600c YP_170516.1 fumerate hydratase Virulence factor MUTATION: a fumA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1951C, under C: Energy production and conversion 17420240 625 cca Francisella tularensis 3191540 56707282 FTT0108c YP_169178.1 tRNA CCA-pyrophosphorylase Virulence factor MUTATION: cca mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0617J, under J: Translation, ribosomal structure and biogenesis 17389372 626 dsbB Francisella tularensis 3191543 56707281 FTT0107c YP_169177.1 disulfide bond formation protein Virulence factor MUTATION: dsbB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 627 gcvH Francisella tularensis 3191553 56707557 FTT0408 YP_169453.1 glycine cleavage system H protein Virulence factor MUTATION: gcvH mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0509E, under E: Amino acid transport and metabolism 17389372 628 elbB Francisella tularensis 3191558 56707776 FTT0654 YP_169672.1 isoprenoid biosynthesis protein with amidotransferase-like domain Virulence factor MUTATION: a elbB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3155Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 629 iglB Francisella tularensis 3191564 56708414 FTT1358c YP_170310.1 intracellular growth locus, subunit B Virulence factor MUTATION: an iglB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3517S, under S: Function unknown 17420240 630 xerC Francisella tularensis 3191568 56708541 FTT1503 YP_170437.1 Integrase/recombinase XerC Virulence factor MUTATION: xerC mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG4973L, under L: Replication, recombination and repair 17389372 631 galE Francisella tularensis 3191584 56707902 FTT0791 YP_169798.1 UDP-glucose 4-epimerase Virulence factor MUTATION: galE mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1087M, under M: Cell wall/membrane/envelope biogenesis 17389372 632 iglC Francisella tularensis 3191591 56708413 FTT1357c YP_170309.1 intracellular growth locus, subunit C Virulence factor MUTATION: an iglC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 633 rluC Francisella tularensis 3191616 56707234 FTT0055 YP_169130.1 ribosomal large subunit pseudouridine synthase C Virulence factor MUTATION: rluC mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0564J, under J: Translation, ribosomal structure and biogenesis 17389372 634 rluB Francisella tularensis 3191617 56708141 FTT1056c YP_170037.1 ribosomal large subunit pseudouridine synthase B Virulence factor MUTATION: a rluB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1187J, under J: Translation, ribosomal structure and biogenesis 17420240 635 ribB Francisella tularensis 3191625 56708682 FTT1672 YP_170578.1 riboflavin synthase subunit alpha Virulence factor MUTATION: ribB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0307H, under H: Coenzyme transport and metabolism 17389372 636 ribA Francisella tularensis 3191626 56708683 FTT1673 YP_170579.1 riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II Virulence factor MUTATION: ribA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0108H, under H: Coenzyme transport and metabolism 17389372 637 relA Francisella tularensis 3191632 56708546 FTT1508c YP_170442.1 GTP pyrophosphokinase Virulence factor MUTATION: relA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0317TK, under T: Signal transduction mechanisms; K: Transcription 17389372 638 recB Francisella tularensis 3191642 56708443 FTT1394c YP_170339.1 Exodeoxyribonuclease V beta chain Virulence factor MUTATION: recB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1074L, under L: Replication, recombination and repair 17389372 639 recA Francisella tularensis 3191643 56708748 FTT1750 YP_170644.1 Recombinase A protein Virulence factor MUTATION: a recA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0468L, under L: Replication, recombination and repair 17420240 640 rbfA Francisella tularensis 3191646 56707230 FTT0051 YP_169126.1 Ribosome-binding factor A Virulence factor MUTATION: rbfA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0858J, under J: Translation, ribosomal structure and biogenesis 17389372 641 qseC Francisella tularensis 3191649 56707270 FTT0094c YP_169166.1 sensor histidine kinase Virulence factor MUTATION: qseC mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0642T, under T: Signal transduction mechanisms 17389372 642 pyrH Francisella tularensis 3191650 56707468 FTT0315 YP_169364.1 uridylate kinase Virulence factor MUTATION: pyrH mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0528F, under F: Nucleotide transport and metabolism 17389372 643 pyrF Francisella tularensis 3191652 56708661 FTT1648c YP_170557.1 Orotidine 5'-phosphate decarboxylase Virulence factor MUTATION: pyrF mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0284F, under F: Nucleotide transport and metabolism 17389372 644 pyrD Francisella tularensis 3191654 56708660 FTT1647c YP_170556.1 diyroorotate dehydrogenase Virulence factor MUTATION: pyrD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0167F, under F: Nucleotide transport and metabolism 17389372 645 pyrB Francisella tularensis 3191656 56708676 FTT1665 YP_170572.1 aspartate carbamoyltransferase Virulence factor MUTATION: pyrB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0540F, under F: Nucleotide transport and metabolism 17389372 646 putA Francisella tularensis 3191660 56708221 FTT1150c YP_170117.1 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase Virulence factor MUTATION: putA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG4230C, under C: Energy production and conversion 17389372 647 purN Francisella tularensis 3191663 56707996 FTT0895 YP_169892.1 phosphoribosylglycinamide formyltransferase Virulence factor MUTATION: purN mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0299F, under F: Nucleotide transport and metabolism 17389372 648 purM Francisella tularensis 3191664 56707994 FTT0893 YP_169890.1 phosphoribosylaminoimidazole synthetase Virulence factor MUTATION: purM mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0150F, under F: Nucleotide transport and metabolism 17389372 649 purL Francisella tularensis 3191665 56708726 FTT1720c YP_170622.1 phosphoribosylformylglycinamidine synthase Virulence factor MUTATION: purL mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0046F, under F: Nucleotide transport and metabolism 17389372 650 purH Francisella tularensis 3191667 56707367 FTT0203c YP_169263.1 bifunctional purine biosynthesis protein Virulence factor MUTATION: purH mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0138F, under F: Nucleotide transport and metabolism 17389372 651 purF Francisella tularensis 3191669 56708727 FTT1721c YP_170623.1 amidophosphoribosyltransferase Virulence factor MUTATION: purF mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0034F, under F: Nucleotide transport and metabolism 17389372 652 purE Francisella tularensis 3191675 56707997 FTT0896 YP_169893.1 phosphoribosylaminoimidazole carboxylase,catalyic subunit Virulence factor MUTATION: purE mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0041F, under F: Nucleotide transport and metabolism 17389372 653 FTT1151c Francisella tularensis 3191681 56708222 FTT1151c YP_170118.1 hypothetical protein Virulence factor MUTATION: FTT1151c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2938S, under S: Function unknown 17389372 654 FTT0918 Francisella tularensis 3191684 56708019 FTT0918 YP_169915.1 hypothetical protein Virulence factor MUTATION: a FTT0918 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 655 FTT0910 Francisella tularensis 3191688 56708011 FTT0910 YP_169907.1 hypothetical protein Virulence factor MUTATION: a FTT0910 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG3240IR, under I: Lipid transport and metabolism; R: General function prediction only 17420240 656 FTT0905 Francisella tularensis 3191692 56708006 FTT0905 YP_169902.1 Type IV pili glycosylation protein Virulence factor MUTATION: FTT0905 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 657 FTT0903 Francisella tularensis 3191693 56708004 FTT0903 YP_169900.1 hypothetical protein Virulence factor MUTATION: FTT0903 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 658 secE Francisella tularensis 3191695 56707308 FTT0138 YP_169204.1 preprotein translocase subunit SecE Virulence factor MUTATION: a secE mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0690U, under U: Intracellular trafficking, secretion, and vesicular transport 17420240 659 FTT0891 Francisella tularensis 3191699 56707992 FTT0891 YP_169888.1 hypothetical protein Virulence factor MUTATION: FTT0891 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0671I, under I: Lipid transport and metabolism 17389372 660 FTT0881c Francisella tularensis 3191712 56707984 FTT0881c YP_169880.1 amino acid permease Virulence factor MUTATION: a FTT0881c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0833E, under E: Amino acid transport and metabolism 17420240 661 FTT1129c Francisella tularensis 3191730 56708206 FTT1129c YP_170102.1 hypothetical protein Virulence factor MUTATION: FTT1129c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0769M, under M: Cell wall/membrane/envelope biogenesis 17389372 662 FTT0843 Francisella tularensis 3191744 0 FTT0843 - pseudo Virulence factor MUTATION: a FTT0843 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 663 FTT1747 Francisella tularensis 3191766 56708745 FTT1747 YP_170641.1 outer membrane protein Virulence factor MUTATION: a FTT1747 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2825M, under M: Cell wall/membrane/envelope biogenesis 17420240 664 apt Francisella tularensis 3191768 56707257 FTT0078 YP_169153.1 adenine phosphoribosyltransferase Virulence factor MUTATION: apt mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0503F, under F: Nucleotide transport and metabolism 17389372 665 phoH Francisella tularensis 3191788 56707742 FTT0617c YP_169638.1 phoH-like protein Virulence factor MUTATION: phoH mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1702T, under T: Signal transduction mechanisms 17389372 666 lpnA Francisella tularensis 3191792 56708002 FTT0901 YP_169898.1 conserved hypothetical lipoprotein Virulence factor MUTATION: a FTT0901 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 667 lpxB Francisella tularensis 3191793 56708594 FTT1568c YP_170490.1 Lipid-A-disaccharide synthase Virulence factor MUTATION: a lpxB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0763M, under M: Cell wall/membrane/envelope biogenesis 17420240 668 FTT0800 Francisella tularensis 3191810 56707911 FTT0800 YP_169807.1 haloacid dehalogenase-like hydrolase family protein Virulence factor MUTATION: FTT0800 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1011R, under R: General function prediction only 17389372 669 FTT0799 Francisella tularensis 3191811 56707910 FTT0799 YP_169806.1 glycosyl transferase group 1 family protein Virulence factor MUTATION: FTT0799 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17389372 670 FTT0798 Francisella tularensis 3191812 56707909 FTT0798 YP_169805.1 glycosyl transferase family protein Virulence factor MUTATION: FTT0798 mutant is attenuated in mice [Ref6382:Weiss et al., 2007]. COG0463M, under M: Cell wall/membrane/envelope biogenesis 17389372 671 FTT0793 Francisella tularensis 3191818 56707904 FTT0793 YP_169800.1 ABC transporter, ATP-binding and membrane protein Virulence factor MUTATION: FTT0793 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1132V, under V: Defense mechanisms 17389372 672 FTT0790 Francisella tularensis 3191819 56707901 FTT0790 YP_169797.1 bacterial sugar transferase family protein Virulence factor MUTATION: FTT0790 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2148M, under M: Cell wall/membrane/envelope biogenesis 17389372 673 FTT0797 Francisella tularensis 3191827 56707908 FTT0797 YP_169804.1 glycosyl transferase family protein Virulence factor MUTATION: FTT0797 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1215M, under M: Cell wall/membrane/envelope biogenesis 17389372 674 FTT0807 Francisella tularensis 3191829 56707918 FTT0807 YP_169814.1 hypothetical protein Virulence factor MUTATION: a FTT0807 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 675 FTT0759 Francisella tularensis 3191841 56707873 FTT0759 YP_169769.1 hypothetical protein Virulence factor MUTATION: a FTT0759 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG5006R, under R: General function prediction only 17420240 676 FTT0792 Francisella tularensis 3191845 56707903 FTT0792 YP_169799.1 glycosyl transferase group 1 family protein Virulence factor MUTATION: FTT0792 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17389372 677 FTT0748 Francisella tularensis 3191851 56707863 FTT0748 YP_169759.1 hypothetical protein Virulence factor MUTATION: FTT0748 mutant is strongly attenuated in mice [Ref6382:Weiss et al., 2007]. COG1414K, under K: Transcription 17389372 678 fadD1 Francisella tularensis 3191870 56708316 FTT1254 YP_170212.1 Acyl-CoA synthetase (long-chain-fatty-acid--CoA ligase) Virulence factor MUTATION: fadD1 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism 17389372 679 fadB/acbP Francisella tularensis 3191871 56708564 FTT1530 YP_170460.1 fusion product of 3-hydroxacyl-CoA dehydrogenase and acyl-CoA-binding protein Virulence factor MUTATIONO: a fadB/acbP mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1250I, under I: Lipid transport and metabolism 17420240 680 feoB Francisella tularensis 3191885 56707405 FTT0249 YP_169301.1 ferrous iron transport protein Virulence factor MUTATION: a feoB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0370P, under P: Inorganic ion transport and metabolism 17420240 681 cphB Francisella tularensis 3191887 56707913 FTT0802 YP_169809.1 Cyanophycinase Virulence factor MUTATION: a cphB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG4242QP, under Q: Secondary metabolites biosynthesis, transport and catabolism; P: Inorganic ion transport and metabolism 17420240 682 cphA Francisella tularensis 3191888 56708207 FTT1130c YP_170103.1 cyanophycin synthetase Virulence factor MUTATION: cphA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0769M, under M: Cell wall/membrane/envelope biogenesis 17389372 683 uvrA Francisella tularensis 3191913 56708369 FTT1312c YP_170265.1 DNA excision repair enzyme, subunit A (UvrABC system protein A), ABC transporter, ATP-binding protein Virulence factor MUTATION: a uvrA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0178L, under L: Replication, recombination and repair 17420240 684 cyoB Francisella tularensis 3191917 56707436 FTT0282 YP_169332.1 Cytochrome O ubiquinol oxidase subunit I Virulence factor MUTATION: cyoB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0843C, under C: Energy production and conversion 17389372 685 cyoC Francisella tularensis 3191921 56707437 FTT0283 YP_169333.1 Cytochrome O ubiquinol oxidase, subunit III Virulence factor MUTATION: a cyoC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1845C, under C: Energy production and conversion 17420240 686 cyoD Francisella tularensis 3191924 56707438 FTT0284 YP_169334.1 Cytochrome O ubiquinol oxidase subunit IV Virulence factor MUTATION: cyoD mutant is attenuated in mice [Ref6382:Weiss et al., 2007]. COG3125C, under C: Energy production and conversion 17389372 687 folD Francisella tularensis 3191934 56707993 FTT0892 YP_169889.1 methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase putative bifunctional protein Virulence factor MUTATION: folD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0190H, under H: Coenzyme transport and metabolism 17389372 688 wbtA Francisella tularensis 3191939 56708505 FTT1464c YP_170401.1 dTDP-glucose 4,6-dehydratase Virulence factor MUTATION: a wbtA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1086MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism 17420240 689 FTT1416c Francisella tularensis 3191965 56708463 FTT1416c YP_170359.1 Hypothetical lipoprotein Virulence factor MUTATION: a FTT1416c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 690 rpsA from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3191976 56707348 FTT0183c YP_169244.1 30S ribosomal protein S1 Virulence factor MUTATION: a rpsA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0539J, under J: Translation, ribosomal structure and biogenesis 17420240 691 rpoA2 Francisella tularensis 3191983 56708484 FTT1442c YP_170380.1 DNA-directed RNA polymerase subunit alpha Virulence factor MUTATION: a rpoA2 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0202K, under K: Transcription 17420240 692 rpmJ from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3191985 56707499 FTT0346 YP_169395.1 50S ribosomal protein L36 Virulence factor MUTATION: a rpmJ mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 693 rpmA from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3191996 56707885 FTT0773 YP_169781.1 50S ribosomal protein L27 Virulence factor MUTATION: a rpmA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0211J, under J: Translation, ribosomal structure and biogenesis 17420240 694 rplY Francisella tularensis 3191997 56707795 FTT0675 YP_169691.1 50S ribosomal protein L25 Virulence factor MUTATION: a rplY mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1825J, under J: Translation, ribosomal structure and biogenesis 17420240 695 rplW Francisella tularensis 3191999 56707480 FTT0327 YP_169376.1 50S ribosomal protein L23 Virulence factor MUTATION: rplW mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0089J, under J: Translation, ribosomal structure and biogenesis 17389372 696 rplT from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3192002 56707931 FTT0820 YP_169827.1 50S ribosomal protein L20 Virulence factor MUTATION: a rplT mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0292J, under J: Translation, ribosomal structure and biogenesis 17420240 697 fopA Francisella tularensis 3192005 56707711 FTT0583 YP_169607.1 outer membrane associated protein Virulence factor MUTATION: a fopA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2885M, under M: Cell wall/membrane/envelope biogenesis 17420240 698 rplQ Francisella tularensis 3192007 56707504 FTT0351 YP_169400.1 50S ribosomal protein L17 Virulence factor MUTATION: rplQ mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0203J, under J: Translation, ribosomal structure and biogenesis 17389372 699 rplD Francisella tularensis 3192020 56707479 FTT0326 YP_169375.1 50S ribosomal protein L4 Virulence factor MUTATION: rplD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0088J, under J: Translation, ribosomal structure and biogenesis 17389372 700 FTT1048c Francisella tularensis 3192037 56708135 FTT1048c YP_170031.1 hypothetical protein Virulence factor MUTATION: FTT1048c mutant is mildly attenuated in mice [Ref6382:Weiss et al., 2007]. 17389372 701 FTT1047c Francisella tularensis 3192038 56708134 FTT1047c YP_170030.1 hypothetical protein Virulence factor MUTATION: FTT1047c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 702 FTT1015 Francisella tularensis 3192056 56708104 FTT1015 YP_170000.1 hypothetical protein Virulence factor MUTATION: a FTT1015 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 703 secA Francisella tularensis 3192077 56707883 FTT0769 YP_169779.1 preprotein translocase subunit SecA Virulence factor MUTATION: a secA mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0653U, under U: Intracellular trafficking, secretion, and vesicular transport 17420240 704 wbtD Francisella tularensis 3192078 56708502 FTT1461c YP_170398.1 galacturonosyl transferase Virulence factor MUTATION: wbtD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17389372 705 wbtF Francisella tularensis 3192079 56708500 FTT1459c YP_170396.1 NAD dependent epimerase Virulence factor MUTATION: a wbtF mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0451MG, under M: Cell wall/membrane/envelope biogenesis; G: Carbohydrate transport and metabolism 17420240 706 wbtG Francisella tularensis 3192084 56708498 FTT1457c YP_170394.1 glycosyl transferase Virulence factor MUTATION: wbtG mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0438M, under M: Cell wall/membrane/envelope biogenesis 17389372 707 wbtH Francisella tularensis 3192087 56708497 FTT1456c YP_170393.1 asparagine synthase Virulence factor MUTATION: wbtH mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0367E, under E: Amino acid transport and metabolism 17389372 708 katG Francisella tularensis 3192098 56707839 FTT0721c YP_169735.1 Peroxidase/catalase Virulence factor MUTATION: a katG mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0376P, under P: Inorganic ion transport and metabolism 17420240 709 xasA Francisella tularensis 3192117 56707622 FTT0480c YP_169518.1 Glutamate:gamma-aminobutyric acid antiporter family protein (APC family protein) Virulence factor MUTATION: xasA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0531E, under E: Amino acid transport and metabolism 17389372 710 xerD Francisella tularensis 3192118 56707324 FTT0154 YP_169220.1 Integrase/recombinase Virulence factor MUTATION: xerD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG4974L, under L: Replication, recombination and repair 17389372 711 FTT0028c Francisella tularensis 3192141 56707208 FTT0028c YP_169104.1 hypothetical protein Virulence factor MUTATION: FTT0028c mutant is attenuated in mice [Ref6382:Weiss et al., 2007]. 17389372 712 FTT0029c Francisella tularensis 3192145 56707209 FTT0029c YP_169105.1 hypothetical protein Virulence factor MUTATION: a FTT0029c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG4264Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17420240 713 FTT0057 Francisella tularensis 3192151 56707236 FTT0057 YP_169132.1 hypothetical membrane protein Virulence factor MUTATION: FTT0057 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 714 FTT0053 Francisella tularensis 3192152 56707232 FTT0053 YP_169128.1 major facilitator superfamily (MFS) transport protein Virulence factor MUTATION: FTT0053 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2271G, under G: Carbohydrate transport and metabolism 17389372 715 FTT0056c Francisella tularensis 3192153 56707235 FTT0056c YP_169131.1 major facilitator superfamily (MFS) transport protein Virulence factor MUTATION: FTT0056c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2223P, under P: Inorganic ion transport and metabolism 17389372 716 yegQ Francisella tularensis 3192162 56708732 FTT1726 YP_170628.1 protease yegQ Virulence factor MUTATION: a yegQ mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0826O, under O: Posttranslational modification, protein turnover, chaperones 17420240 717 FTT0101 Francisella tularensis 3192163 56707276 FTT0101 YP_169172.1 conserved membrane hypothetical protein Virulence factor MUTATION: a FTT0101 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1619V, under V: Defense mechanisms 17420240 718 yfdH Francisella tularensis 3192164 56707596 FTT0454 YP_169492.1 glycosyl transferase, group 2 family protein Virulence factor MUTATION: yfdH mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0463M, under M: Cell wall/membrane/envelope biogenesis 17389372 719 FTT1152 Francisella tularensis 3192179 56708223 FTT1152 YP_170119.1 hypothetical protein Virulence factor MUTATION: a FTT1152 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 720 ppiC Francisella tularensis 3192184 56708512 FTT1472c YP_170408.1 Peptidyl-prolyl cis-trans isomerase. Virulence factor MUTATION: a ppiC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0760O, under O: Posttranslational modification, protein turnover, chaperones 17420240 721 lolD Francisella tularensis 3192199 56707554 FTT0405 YP_169450.1 lipoprotein releasing system, subunit D, ABC transporter, ATP-binding protein Virulence factor MUTATION: lolD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1136V, under V: Defense mechanisms 17389372 722 FTT1238c Francisella tularensis 3192211 56708300 FTT1238c YP_170196.1 hypothetical membrane protein Virulence factor MUTATION: FTT1238c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 723 FTT1239 Francisella tularensis 3192217 56708301 FTT1239 YP_170197.1 hypothetical membrane protein Virulence factor MUTATION: FTT1239 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 724 FTT1236 Francisella tularensis 3192220 56708298 FTT1236 YP_170194.1 hypothetical protein Virulence factor MUTATION: FTT1236 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. 17389372 725 FTT1237 Francisella tularensis 3192224 56708299 FTT1237 YP_170195.1 glycosyl transferase family 8 protein Virulence factor MUTATION: FTT1237 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1442M, under M: Cell wall/membrane/envelope biogenesis 17389372 726 FTT1221 Francisella tularensis 3192229 56708283 FTT1221 YP_170179.1 hypothetical protein Virulence factor MUTATION: a FTT1221 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0271T, under T: Signal transduction mechanisms 17420240 727 FTTt19 Francisella tularensis 3192238 0 FTTt19 - tRNA Virulence factor MUTATION: a FTTt19 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 728 manB Francisella tularensis 3192273 56708489 FTT1447c YP_170385.1 Phosphomannomutase Virulence factor MUTATION: manB mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1109G, under G: Carbohydrate transport and metabolism 17389372 729 FTTr07 Francisella tularensis 3192274 0 FTTr07 - 16S ribosomal RNA Virulence factor MUTATION: a FTTr07 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 730 lysA Francisella tularensis 3192305 56707207 FTT0027c YP_169103.1 diaminopimelate decarboxylase Virulence factor MUTATION: lysA mutant is attenuated in mice [Ref6382:Weiss et al., 2007]. COG0019E, under E: Amino acid transport and metabolism 17389372 731 ispA Francisella tularensis 3192308 56708589 FTT1562 YP_170485.1 Geranyltranstransferase Virulence factor MUTATION: ispA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0142H, under H: Coenzyme transport and metabolism 17389372 732 bioA Francisella tularensis 3192333 56708035 FTT0938 YP_169931.1 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase Virulence factor MUTATION: bioA mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0161H, under H: Coenzyme transport and metabolism 17389372 733 emrA1 Francisella tularensis 3192360 56708319 FTT1257 YP_170215.1 HlyD family secretion protein Virulence factor MUTATION: emrA1 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1566V, under V: Defense mechanisms 17389372 734 clpP Francisella tularensis 3192361 56707749 FTT0624 YP_169645.1 ATP-dependent Clp protease subunit P Virulence factor MUTATION: a clpP mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0740OU, under O: Posttranslational modification, protein turnover, chaperones; U: Intracellular trafficking, secretion, and vesicular transport 17420240 735 capC Francisella tularensis 3192366 56707917 FTT0806 YP_169813.1 capsule biosynthesis protein CapC Virulence factor MUTATION: a capC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 736 FTT1676 Francisella tularensis 3192368 56708686 FTT1676 YP_170582.1 hypothetical membrane protein Virulence factor MUTATION: a FTT1676 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] 17420240 737 sdaC1 Francisella tularensis 3192377 56707831 FTT0712c YP_169727.1 serine transporter Virulence factor MUTATION: sdaC1 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0814E, under E: Amino acid transport and metabolism 17389372 738 yjjK Francisella tularensis 3192393 56708774 FTT1782c YP_170670.1 putative ABC transporter ATP-binding protein Virulence factor MUTATION: a yjjK mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0488R, under R: General function prediction only 17420240 739 hflK Francisella tularensis 3192426 56707758 FTT0633 YP_169654.1 SPFH domain, band 7 family protein Virulence factor MUTATION: a hflK mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0330O, under O: Posttranslational modification, protein turnover, chaperones 17420240 740 hflX Francisella tularensis 3192427 56707756 FTT0631 YP_169652.1 protease, GTP-binding subunit Virulence factor MUTATION: a hflX mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2262R, under R: General function prediction only 17420240 741 hisS Francisella tularensis 3192430 56707231 FTT0052 YP_169127.1 histidyl-tRNA synthetase Virulence factor MUTATION: hisS mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0124J, under J: Translation, ribosomal structure and biogenesis 17389372 742 FTT0968c Francisella tularensis 3192433 56708061 FTT0968c YP_169957.1 amino acid antiporter Virulence factor MUTATION: a FTT0968c mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0531E, under E: Amino acid transport and metabolism 17420240 743 minD Francisella tularensis 3192434 56708626 FTT1606 YP_170522.1 septum site-determining protein MinD Virulence factor MUTATION: a minD mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG2894D, under D: Cell cycle control, cell division, chromosome partitioning 17420240 744 FTT0945 Francisella tularensis 3192454 56708042 FTT0945 YP_169938.1 chorismate binding family protein Virulence factor MUTATION: FTT0945 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0147EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism 17389372 745 FTT0944 Francisella tularensis 3192455 56708041 FTT0944 YP_169937.1 AMP-binding family protein Virulence factor MUTATION: FTT0944 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0318IQ, under I: Lipid transport and metabolism; Q: Secondary metabolites biosynthesis, transport and catabolism 17389372 746 FTT0941c Francisella tularensis 3192456 56708038 FTT0941c YP_169934.1 Lipase/esterase Virulence factor MUTATION: a FTT0941c mutant was attenuated for infection in a mouse lung[Ref6340:Su et al., 2007] COG0657I, under I: Lipid transport and metabolism 17420240 747 FTT0940c Francisella tularensis 3192457 56708037 FTT0940c YP_169933.1 hypothetical protein Virulence factor MUTATION: FTT0940c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG2050Q, under Q: Secondary metabolites biosynthesis, transport and catabolism 17389372 748 FTT0928c Francisella tularensis 3192464 56708028 FTT0928c YP_169924.1 Beta-glucosidase-related glycosidase Virulence factor MUTATION: FTT0928c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1472G, under G: Carbohydrate transport and metabolism 17389372 749 minC Francisella tularensis 3192486 56708625 FTT1605 YP_170521.1 septum site-determining protein MinC Virulence factor MUTATION: a minC mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0850D, under D: Cell cycle control, cell division, chromosome partitioning 17420240 750 ampD Francisella tularensis 3192487 56707332 FTT0162 YP_169228.1 N-acetyl-anhydromuranmyl-L-alanine amidase Virulence factor MUTATION: ampD mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG3023V, under V: Defense mechanisms 17389372 751 FTT1490 Francisella tularensis 3192492 56708529 FTT1490 YP_170425.1 Na+/H+ antiporter Virulence factor MUTATION: FTT1490 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0025P, under P: Inorganic ion transport and metabolism 17389372 752 gcvP1 Francisella tularensis 3192502 56707558 FTT0409 YP_169454.1 glycine dehydrogenase subunit 1 Virulence factor MUTATION: gcvP1 mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0403E, under E: Amino acid transport and metabolism 17389372 753 clpX Francisella tularensis 3192507 56707750 FTT0625 YP_169646.1 ATP-dependent protease ATP-binding subunit Virulence factor MUTATION: a clpX mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1219O, under O: Posttranslational modification, protein turnover, chaperones 17420240 754 clpB Francisella tularensis 3192509 56708764 FTT1769c YP_170660.1 ClpB protein Virulence factor MUTATION: a clpB mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0542O, under O: Posttranslational modification, protein turnover, chaperones 17420240 755 gcvT Francisella tularensis 3192518 56707556 FTT0407 YP_169452.1 glycine cleavage system aminomethyltransferase T Virulence factor MUTATION: gcvT mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG0404E, under E: Amino acid transport and metabolism 17389372 756 FTT0165c Francisella tularensis 3192524 56707335 FTT0165c YP_169231.1 conserved hypothetical lipoprotein Virulence factor MUTATION: FTT0165c mutant is attenuated in mouse spleen [Ref6382:Weiss et al., 2007]. COG1520S, under S: Function unknown 17389372 757 aspC2 Francisella tularensis 3192538 56708235 FTT1165c YP_170131.1 aspartate aminotransferase Virulence factor MUTATION: a aspC2 mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG0436E, under E: Amino acid transport and metabolism 17420240 758 glpX from Francisella tularensis subsp. tularensis SCHU S4 Francisella tularensis subsp. tularensis SCHU S4 3192549 56708648 FTT1631c YP_170544.1 fructose 1,6-bisphosphatase II Virulence factor MUTATION: a glpX mutant was attenuated for infection in a mouse lung [Ref6340:Su et al., 2007] COG1494G, under G: Carbohydrate transport and metabolism 17420240 4866 LPS Francisella tularensis Virulence factor MUTATION: OAg LPS mutants of both subsp. tularensis and subsp. novicida are attenuated for virulence in mice [Ref7291:Barker and Klose, 2007]. 17395737 4911 guaA Francisella tularensis subsp. holarctica LVS 3951701 89256406 FTL_1071 AM233362 YP_513768 GMP synthase Virulence factor MUTATION: A guaA mutant is highly attenuated in mice [Ref7339:Santiago et al., 2009]. COG0519F, under F: Nucleotide transport and metabolism 19368784 4912 guaB Francisella tularensis subsp. holarctica FTNF002-00 5523917 156502929 FTA_1563 CP000803 YP_001428994 inosine-5'-monophosphate dehydrogenase Virulence factor MUTATION: A guaB mutant is attenuated in mice [Ref7339:Santiago et al., 2009]. COG0516F, under F: Nucleotide transport and metabolism 19368784 4913 wbtI Francisella tularensis subsp. holarctica FTNF002-00 5522688 156502002 FTA_0635 CP000803 YP_001428067 DegT/DnrJ/EryC1/StrS family sugar aminotransferase Virulence factor MUTATION: A wbtI mutant is attenuated in mice [Ref7340:Li et al., 2007]. COG0399M, under M: Cell wall/membrane/envelope biogenesis 17768257 4970 sodC Francisella tularensis subsp. holarctica FTNF002-00 5522867 156501771 FTA_0403 CP000803 YP_001427836 copper/zinc superoxide dismutase Virulence factor MUTATION: A sodC mutant in Francisella tularensis subspecies holarctica was attenuated in mice [Ref7384:Melillo et al., 2009]. COG2032P, under P: Inorganic ion transport and metabolism 19684141 4971 purC/purD Francisella tularensis subsp. holarctica LVS 3952576 89255807 FTL_0396 AM233362 YP_513169 fusion protein PurC/PurD Virulence factor MUTATION: A purMCD mutant in Francisela tularensis was attenuated in mice [Ref7385:Pechous et al., 2006]. COG0151F, under F: Nucleotide transport and metabolism 16861631 4972 FTL0552 Francisella tularensis subsp. holarctica LVS 3952730 89255956 FTL_0552 AM233362 YP_513318 two-component response regulator Virulence factor MUTATION: A FTL0552 mutant in Francisella tularensis was attenuated in mice [Ref7386:Sammons-Jackson et al., 2008]. COG0745TK, under T: Signal transduction mechanisms; K: Transcription 18613792