PHIDIAS: Pathogen-Host Interaction Data Integration and Analysis System

Phinet Name: Clostridium botulinum
Phinet Information
Pathogen Name: Clostridium botulinum
Pathogen NIAID Category: NIAID Category A
Bio-objects
Bio-object 1: Absorptive cells
Type: Location: Function: Description:
Bio-object 2: Botulinum protoxin
Type: Location: Function: Description:
Bio-object 3: Botulinum toxin. Food infection/Primary intoxication
Type: Location: Function: Description:
Bio-object 4: Botulinum toxin. Primary human infection/Secondary intoxication
Type: Location: Function: Description:
Bio-object 5: Clostridium botulinum
Type: Location: Function: Description:
Bio-object 6: Endosome membrane. Toxin penetration by pH-induced translocation
Type: Location: Function: Description:
Bio-object 7: M cells
Type: Location: Function: Description:
Bio-object 8: Nerve terminus cytosol. Toxin penetration to the nerve terminus cytosol
Type: Location: Function: Description:
Bio-object 9: Neuromuscular junctions. Expression of toxicity-flaccid paralysis
Type: Location: Description:
Bio-object 10: Plasma membrane. Toxin penetration by receptor-mediated endocytosis
Type: Location: Function: Description:
Bio-object 11: Progenitor toxin complex. Formation and release
Type: Location: Function: Description:
Bio-object 12: Protoxin. Nicking by protease
Type: Location: Function: Description:
Bio-object 13: Receptor-Toxin. Toxin and target cell binding
Type: Location: Function: Description:
Bio-object 14: Toxin (Neurotoxin). Expression of toxicity-blocking acetylcholine release
Type: Location: Function: Description:
Bio-object 15: Transport cells. Toxin binding to intestinal epithelial cell surface
Type: Location: Function: Description:
Interactions
Interaction 1: I1
Input Objects: Clostridium botulinum Output Objects: Botulinum protoxin GO Evidence Code: Inferred from Direct Assay Description:
Interaction 2: I2
Input Objects: Botulinum protoxin Output Objects: Protoxin. Nicking by protease GO Evidence Code: Inferred from Direct Assay Description:
Interaction 3: I3
Input Objects: Protoxin. Nicking by protease Output Objects: Progenitor toxin complex. Formation and release GO Evidence Code: Inferred from Direct Assay Description:
Interaction 4: I4
Input Objects: Progenitor toxin complex. Formation and release Output Objects: Botulinum toxin. Food infection/Primary intoxication, Botulinum toxin. Primary human infection/Secondary intoxication GO Evidence Code: Inferred from Direct Assay Description:
Interaction 5: I5
Input Objects: Progenitor toxin complex. Formation and release, Botulinum toxin. Food infection/Primary intoxication, Botulinum toxin. Primary human infection/Secondary intoxication Output Objects: Transport cells. Toxin binding to intestinal epithelial cell surface GO Evidence Code: Inferred from Direct Assay Description:
Interaction 6: I6
Input Objects: Transport cells. Toxin binding to intestinal epithelial cell surface Output Objects: Absorptive cells, M cells GO Evidence Code: Inferred from Direct Assay Description:
Interaction 7: I7
Input Objects: Absorptive cells, M cells Output Objects: Receptor-Toxin. Toxin and target cell binding GO Evidence Code: Inferred from Direct Assay Description:
Interaction 8: I8
Input Objects: Receptor-Toxin. Toxin and target cell binding Output Objects: Nerve terminus cytosol. Toxin penetration to the nerve terminus cytosol GO Evidence Code: Inferred from Direct Assay Description:
Interaction 9: I9
Input Objects: Nerve terminus cytosol. Toxin penetration to the nerve terminus cytosol Output Objects: Plasma membrane. Toxin penetration by receptor-mediated endocytosis GO Evidence Code: Inferred from Direct Assay Description:
Interaction 10: I10
Input Objects: Plasma membrane. Toxin penetration by receptor-mediated endocytosis Output Objects: Endosome membrane. Toxin penetration by pH-induced translocation GO Evidence Code: Inferred from Direct Assay Description:
Interaction 11: I11
Input Objects: Endosome membrane. Toxin penetration by pH-induced translocation Output Objects: Toxin (Neurotoxin). Expression of toxicity-blocking acetylcholine release GO Evidence Code: Inferred from Direct Assay Description:
Interaction 12: I12
Input Objects: Toxin (Neurotoxin). Expression of toxicity-blocking acetylcholine release Output Objects: Neuromuscular junctions. Expression of toxicity-flaccid paralysis GO Evidence Code: Inferred from Direct Assay Description:
Pathways

Phinet Name: Clostridium botulinum