Cell membrane Complex Enzyme Eukaryotic cell or cell component Microbe-host cell complex Microorganism or its component Other Other -- ion Pathway or action Protein Protein or gene Protein or gene complex Protein or protein complex Bacterial membrane or virus envelope Cell membrane Cytoplasm Eukaryotic cell or cell component Extracellular Golgi Golgi membrane Intercellular Intracellular Mitochondria Nucleocapsid/Cytoplasm Organelle Organelle -- Cell membrane Organelle -- Endoplasmic reticulum Organelle -- ER Organelle -- Golgi Organelle -- Golgi membrane Organelle -- Nucleus Organelle -- Phagolysosome Organelle -- Phagosome Organelle -- Ribosome Other Phagolysosome Phagosome Chaperone Defense, immunity protein Enzyme Enzyme activator Enzyme inhibitor Genomic S segment Infection Ligand binding or carrier Motor Nucleic acid binding Other Signal transducer Toxicity Transcription factor binding Transcription regulation Transporter Unknown IC Inferred by Curator IDA Inferred from Direct Assay IEA Inferred from Electronic Annotation IEP Inferred from Expression Pattern IGI Inferred from Genetic Interaction IMP Inferred from Mutant Phenotype IPI Inferred from Physical Interaction ISS Inferred from Sequence or Structural Similarity NAS Non-traceable Author Statement ND No biological Data available RCA inferred from Reviewed Computational Analysis TAS Traceable Author Statement NR Not Recorded Lethal Factor Function: Enzyme. Free Lethal Factor Function: Enzyme. Edema Factor Function: Enzyme. Free Edema Factor(inactive) Function: Enzyme. Protective Antigen(86) Function: Enzyme. Protective Antigen(63) (6 molecules) Function: Enzyme. Protective Antigen(86) + ATR Function: Enzyme. Furin Function: Enzyme. Furin Function: Enzyme. Protective Antigen(86) + ATR + Furin Function: Enzyme. Protective Antigen(63) + ATR Function: Enzyme. Protective Antigen(63)-Heptamer + ATR (7 Molecules) Function: Enzyme. Protective Antigen(63)-Heptamer + ATR (7 Molecules) + LF / EF Function: Enzyme. ATR Function: Ligand binding or carrier. Macrophage Cell Surface Function: . Endosome containing Toxin complex Function: . Lysosome Function: . Phagolysosome Function: . Acidified Phagolysosome Function: . H+ Function: Signal transducer. Ca2+ Influx Function: Signal transducer. Calmodulin Function: Signal transducer. Calmodulin + EF(active) Function: Signal transducer. ATP Function: Motor. Increased cyclicAMP Function: Signal transducer. Interleukin6 expression suppressed Function: Defense, immunity protein. TNF alpha expression suppressed Function: Defense, immunity protein. Cytokine expression suppressed Function: Defense, immunity protein. NF-kappa-B repression Function: Transcription regulation. MAPKK Function: Enzyme. MAPKK degraded Function: Enzyme. Mg2+ Function: . Calmodulin + active(EF+Mg2+ATP) Function: . Apoptosis Function: Unknown.