Cell membrane Complex Enzyme Eukaryotic cell or cell component Microbe-host cell complex Microorganism or its component Other Other -- ion Pathway or action Protein Protein or gene Protein or gene complex Protein or protein complex Bacterial membrane or virus envelope Cell membrane Cytoplasm Eukaryotic cell or cell component Extracellular Golgi Golgi membrane Intercellular Intracellular Mitochondria Nucleocapsid/Cytoplasm Organelle Organelle -- Cell membrane Organelle -- Endoplasmic reticulum Organelle -- ER Organelle -- Golgi Organelle -- Golgi membrane Organelle -- Nucleus Organelle -- Phagolysosome Organelle -- Phagosome Organelle -- Ribosome Other Phagolysosome Phagosome Chaperone Defense, immunity protein Enzyme Enzyme activator Enzyme inhibitor Genomic S segment Infection Ligand binding or carrier Motor Nucleic acid binding Other Signal transducer Toxicity Transcription factor binding Transcription regulation Transporter Unknown IC Inferred by Curator IDA Inferred from Direct Assay IEA Inferred from Electronic Annotation IEP Inferred from Expression Pattern IGI Inferred from Genetic Interaction IMP Inferred from Mutant Phenotype IPI Inferred from Physical Interaction ISS Inferred from Sequence or Structural Similarity NAS Non-traceable Author Statement ND No biological Data available RCA inferred from Reviewed Computational Analysis TAS Traceable Author Statement NR Not Recorded Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M Immunity Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators 2005 16169504 PubMed Agrawal A, Pulendran B Cellular and molecular life sciences : CMLS Anthrax lethal toxin: a weapon of multisystem destruction 2004 15558214 PubMed Wickliffe KE, Leppla SH, Moayeri M Cellular microbiology Killing of macrophages by anthrax lethal toxin: involvement of the N-end rule pathway 2008 18266992 PubMed Collier RJ, Young JA Annual review of cell and developmental biology Anthrax toxin 2003 14570563 PubMed Park JM, Greten FR, Li ZW, Karin M Science (New York, N.Y.) Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition 2002 12202685 PubMed Mayr B, Montminy M Nature reviews. Molecular cell biology Transcriptional regulation by the phosphorylation-dependent factor CREB 2001 11483993 PubMed Buck M, Chojkier M American journal of physiology. Cell physiology C/EBPbeta phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin 2007 17855774 PubMed MEKK Function: Signal transducer. Mitogen-activated protein kinase kinase Cebpb-T217 Function: Transcription regulation. RSK Function: Signal transducer. ribosomal protein S6 kinase polypeptide 1 Mapk3 Function: Signal transducer. Mitogen-activated protein kinase 3 Mapk1 Function: Signal transducer. mitogen-activated protein kinase 1 cAMP Function: Other. ?1 Function: Unknown. Cell death Function: Other. CREB Function: Transcription regulation. Two transcript variants known for mRNA (variants A and B). MSK2 Function: Enzyme. ribosomal protein S6 kinase, polypeptide 4 MSK1 Function: Enzyme activator. Ribosomal protein S6 kinase, polypeptide 5 p38 Function: Signal transducer. mitogen-activated protein kinase 14 MKK6 Function: Enzyme. Mitogen-activated protein kinase kinase 6. LT Function: Toxicity. Catalytic subunit (LF) of anthrax lethal toxin (Park et al., 2005). PKA Function: Enzyme activator. protein kinase, cAMP dependent, catalytic, alpha ET Function: Toxicity. B. anthracis endotoxin. Includes EF subunit which catalyzes PKA production (Park et al., 2005). Bfl-1/A1 Function: Other. Major anti-apoptotic gene which was proposed to inhibit cell death along with Bfl-1/A1 (Park et al., 2005). PAI-2 Function: Chaperone. Serpinb2 serine (or cysteine) peptidase inhibitor, clade B, member 2. Pai-2 identified to have Nf-κB and CREB binding sites within its control region via ChIP analysis. Inhibits apoptosis in TLR4-activated macrophages. (Park et al., 2005) Nf-κB Function: Transcription regulation. Nfkb monomers dissociate and translocate to nucleus to induce transcriptional activation following activation of IκB subunits. IκB Function: Enzyme inhibitor. Nf-κB inhibitors which include Nfkbia, Nfkbib, Nfkbie. IKK Function: Signal transducer. Ikbkb (inhibitor of kappaB kinase beta). Other genes related to Ikbkb via IKK complex: Ikbkg, Chuk. TLR4 Function: Signal transducer. Toll-like receptors recognize pathogen-associated molecular patterns (PAMPs) and transduce such signals to IκB and MAP kinases, which can control downstream transcription factor activities, localization, etc. (Park et al., 2005)